Results 51 to 60 of about 12,101,411 (341)
Senescent cells at the crossroads of aging, disease, and tissue homeostasis
Aging Cell, 2023 Originally identified as an outcome of continuous culture of primary cells, cellular senescence has moved beyond the culture dish and is now a bona fide driver of aging and disease in animal models, and growing links to human disease.
Chisaka Kuehnemann, Christopher D. Wiley
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Biological effects of cigarette smoke in cultured human retinal pigment epithelial cells. [PDF]
, 2012 The goal of the present study was to determine whether treatment with cigarette smoke extract (CSE) induces cell loss, cellular senescence, and extracellular matrix (ECM) synthesis in primary human retinal pigment epithelial (RPE) cells. Primary cultured
Johannes Burger +8 more
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Molecules and Cells, 2023 Cellular senescence is a stress-response mechanism implicated in various physiological processes, diseases, and aging. Current detection approaches have partially addressed the issue of senescent cell identification in clinical specimens.
Sophia Magkouta +29 more
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Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development
Frontiers in Cell and Developmental Biology, 2022 Cellular senescence is a process that leads to a state of irreversible cell growth arrest induced by a variety of intrinsic and extrinsic stresses. Senescent cells (SnCs) accumulate with age and have been implicated in various age-related diseases in ...
Li Hu +9 more
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Targeting senescent cells: approaches, opportunities, challenges [PDF]
, 2020 Cellular senescence is a hallmark of aging, whose onset is linked to a series of both cell and non-cell autonomous processes, leading to several consequences for the organism.
Von Kobbe, Cayetano
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Cellular senescence primes liver fibrosis regression through Notch‐EZH2
MedComm, 2023 Cellular senescence plays a pivotal role in wound healing. At the initiation of liver fibrosis regression, accumulated senescent cells were detected and genes of senescence were upregulated.
Ping Song +12 more
doaj +1 more source
Aging Cell, 2022 Cellular senescence, which is a major cause of tissue dysfunction with aging and multiple other conditions, is known to be triggered by p16Ink4a or p21Cip1, but the relative contributions of each pathway toward inducing senescence are unclear.
Abhishek Chandra +13 more
semanticscholar +1 more source
The development of cell senescence
Experimental Gerontology, 2019 Cellular senescence was traditionally considered a stress response that protected the organism by limiting the proliferation of damaged and unwanted cells. However, the recent identification of developmentally-programmed cellular senescence during embryo development has changed our view of the process.
Sabela, Da Silva-Álvarez +6 more
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Inhibition of tyrosine kinase Fgr prevents radiation-induced pulmonary fibrosis (RIPF)
Cell Death Discovery, 2023 Cellular senescence is involved in the development of pulmonary fibrosis as well as in lung tissue repair and regeneration. Therefore, a strategy of removal of senescent cells by senolytic drugs may not produce the desired therapeutic result.
Amitava Mukherjee +11 more
doaj +1 more source
Targeting senescent cell clearance: An approach to delay aging and age-associated disorders
Translational Medicine of Aging, 2021 Cellular senescence is the occurrence of irreversible cell cycle arrest resulting from accumulated DNA damage and the loss of proteostasis over time. Senescent cells contribute to age-related diseases and aging itself. Therefore, the targeted elimination
Zhengqi Qiu +5 more
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