Results 61 to 70 of about 12,101,411 (341)

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Nature, 2011
Advanced age is the main risk factor for most chronic diseases and functional deficits in humans, but the fundamental mechanisms that drive ageing remain largely unknown, impeding the development of interventions that might delay or prevent age-related ...
D. Baker, Tobias Wijshake, T. Tchkonia, N. LeBrasseur, Bennett G. Childs, B. van de Sluis, J. Kirkland, Jan M. van Deursen   +7 more
semanticscholar   +1 more source

Senescent cells suppress macrophage-mediated corpse removal via upregulation of the CD47-QPCT/L axis

Journal of Cell Biology, 2022
Progressive accrual of senescent cells in aging and chronic diseases is associated with detrimental effects in tissue homeostasis. We found that senescent fibroblasts and epithelia were not only refractory to macrophage-mediated engulfment and removal ...
D. Schloesser, Laura Lindenthal, J. Sauer, K. Chung, T. Chavakis, E. Griesser, P. Baskaran, Ulrike Maier-Habelsberger, K. Fundel-Clemens, Ines Schlotthauer, C. K. Watson, L. K. Swee, Frederik Igney, J. Park, M. Huber-Lang, M. Thomas, K. E. El Kasmi, P. J. Murray   +17 more
semanticscholar   +1 more source

Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway.

Immunity
Mitochondrial dysfunction is a hallmark of cellular senescence. Here, we investigated whether senescent cells release mitochondrial (mt)DNA into the extracellular space and its impact on innate immunity.
Ping‐Chang Lai, Lei Liu, Nicoló Bancaro, M. Troiani, B. Calí, Yuxin Li, Jingjing Chen, P. Singh, R. Arzola, Giuseppe Attanasio, N. Pernigoni, E. Pasquini, Simone Mosole, Andrea Rinaldi, Jacopo Sgrignani, Shi Qiu, Pan Song, Yingrui Li, M. A. Desbats, Azucena Rendón Ángel, R. P. Mestre, Andrea Cavalli, L. Barile, Johann de Bono, A. Alimonti   +24 more
semanticscholar   +1 more source

The senescent cell epigenome

Aging, 2018
A critical hallmark of aging is cellular senescence, a state of growth arrest and inflammatory cytokine release in cells, caused by a variety of stresses. Recent work has convincingly linked the accumulation of senescent cells in aged tissues to a decline in health and a limit of lifespan, primarily through "inflammaging".
Yang, Na, Sen, Payel
openaire   +2 more sources

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

Aging Cell, 2015
The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide gene. Achieving the same using small molecules would have a tremendous impact on quality of life and the burden of age‐related chronic diseases.
Yi Zhu, T. Tchkonia, T. Pirtskhalava, A. Gower, H. Ding, N. Giorgadze, Allyson K. Palmer, Y. Ikeno, G. Hubbard, M. Lenburg, S. O’Hara, N. LaRusso, Jordan D. Miller, Carolyn M. Roos, Grace C. Verzosa, N. LeBrasseur, J. Wren, J. Farr, S. Khosla, Michael B. Stout, S. McGowan, Heike Fuhrmann-Stroissnigg, Aditi U. Gurkar, J. Zhao, D. Colangelo, A. Dorronsoro, Y. Ling, Amira S Barghouthy, D. C. Navarro, T. Sano, P. Robbins, L. Niedernhofer, J. Kirkland   +32 more
semanticscholar   +1 more source

SGLT2 inhibition eliminates senescent cells and alleviates pathological aging

Nature Aging
It has been reported that accumulation of senescent cells in various tissues contributes to pathological aging and that elimination of senescent cells (senolysis) improves age-associated pathologies. Here, we demonstrate that inhibition of sodium–glucose
G. Katsuumi, I. Shimizu, M. Suda, Y. Yoshida, T. Furihata, Y. Joki, C. Hsiao, Liang Jiaqi, S. Fujiki, Manabu Abe, Masataka Sugimoto, Tomoyoshi Soga, Tohru Minamino   +12 more
semanticscholar   +1 more source

Release of mitochondrial dsRNA into the cytosol is a key driver of the inflammatory phenotype of senescent cells

Nature Communications
The escape of mitochondrial double-stranded dsRNA (mt-dsRNA) into the cytosol has been recently linked to a number of inflammatory diseases. Here, we report that the release of mt-dsRNA into the cytosol is a general feature of senescent cells and a ...
Vanessa López-Polo, Mate Maus, Emmanouil Zacharioudakis, Miguel Lafarga, C. Attolini, F. Marques, Marta Kovatcheva, E. Gavathiotis, M. Serrano   +8 more
semanticscholar   +1 more source

Targeting senescent cells for a healthier longevity: the roadmap for an era of global aging

Life Medicine, 2022
Aging is a natural but relentless process of physiological decline, leading to physical frailty, reduced ability to respond to physical stresses (resilience) and, ultimately, organismal death.
Yu Sun, Qingfeng Li, J. Kirkland
semanticscholar   +1 more source

The Senolytic Drug JQ1 Removes Senescent Cells via Ferroptosis

, 2021
BACKGROUND: Ferroptosis is an iron-dependent, non-apoptotic programmed cell death. Cellular senescence contributes to aging and various age-related diseases through the expression of a senescence-associated secretory phenotype (SASP). Senescent cells are
Go, Seokhyeong, Kim, Byung-Soo, Jeon, Ok Hee, Kang, Mikyung, Jung, Mungyo, Kwon, Sung Pil, Kim, Byung‐Soo   +6 more
core   +1 more source

The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2

Nature Cancer
Chemotherapy often generates intratumoral senescent cancer cells that strongly modify the tumor microenvironment, favoring immunosuppression and tumor growth.
Selim Chaib, J. López-Domínguez, Marta Lalinde-Gutiérrez, N. Prats, I. Marín, Olga Boix, Andrea García-Garijo, Kathleen Meyer, M. I. Muñoz, M. Aguilera, Lidia Mateo, C. Stephan-Otto Attolini, S. Llanos, Sandra Pérez-Ramos, Marta Escorihuela, F. Al-Shahrour, T. Cash, T. Tchkonia, James L. Kirkland, María Abad, Alena Gros, Joaquan Arribas, M. Serrano   +22 more
semanticscholar   +1 more source