Results 71 to 80 of about 12,101,411 (341)

An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo

Nature Aging, 2021
The role of senescent cells has been implicated in various tissue dysfunctions associated with aging, obesity and other pathological conditions. Currently, most transgenic mouse models target only p16Ink4a-highly expressing (p16high) cells.
Binsheng Wang, Lichao Wang, Nathan S. Gasek, Yueying Zhou, Taewan Kim, Chun Guo, Evan R. Jellison, L. Haynes, S. Yadav, T. Tchkonia, G. Kuchel, J. Kirkland, Ming Xu   +12 more
semanticscholar   +1 more source

Senescent Stromal Cells in the Tumor Microenvironment: Victims or Accomplices?

, 2023
Cellular senescence is a unique cellular state. Senescent cells enter a non-proliferative phase, and the cell cycle is arrested. However, senescence is essentially an active cellular phenotype, with senescent cells affecting themselves and neighboring ...
Minghan Ye, Qianju Wu, Xinyi Huang, Fei Liu   +3 more
core   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Oral Senescence: From Molecular Biology to Clinical Research

Frontiers in Dental Medicine, 2022
Cellular senescence is an irreversible cell cycle arrest occurring following multiple rounds of cell division (replicative senescence) or in response to cellular stresses such as ionizing radiation, signaling imbalances and oxidative damage (stress ...
Eric Kenneth Parkinson, Stephen Stewart Prime   +1 more
doaj   +1 more source

p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells

Nature Cell Biology
The accumulation of senescent cells promotes ageing and age-related diseases, but molecular mechanisms that senescent cells use to evade immune clearance and accumulate in tissues remain to be elucidated.
Julia Majewska, Amit Agrawal, A. Mayo, Lior Roitman, Rishita Chatterjee, Jarmila Sekeresova Kralova, Tomer Landsberger, Yonatan Katzenelenbogen, Tomer Meir-Salame, Efrat Hagai, I. Sopher, J. Perez-Correa, Wolfgang Wagner, Avi Maimon, I. Amit, U. Alon, V. Krizhanovsky   +16 more
semanticscholar   +1 more source

Similarities and interplay between senescent cells and macrophages [PDF]

, 2020
Senescence is a cellular program that prevents the replication of old, damaged, or cancerous cells. Senescent cells become growth arrested and undergo changes in their morphology, chromatin organization, and metabolism, and produce a bioactive secretome.
Jesús Gil, Behmoaras, Jacques, Gil, Jesus, Jacques Behmoaras   +3 more
core   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

T-cell immunity against senescence: potential role and perspectives

Frontiers in Immunology
The development of age-associated diseases is related to the accumulation of senescent cells in the body. These are old non-functional cells with impaired metabolism, which are unable to divide.
Kseniia Matveeva, Mariia Vasilieva, Ekaterina Minskaia, Stanislav Rybtsov, Daniil Shevyrev   +4 more
doaj   +1 more source

Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression and chemoresistance by enhancing the secretion of chemotherapy-induced senescence-associated secretory phenotype via activation of DNA damage response pathway

Gut Microbes, 2023
Senescence frequently occurs in cancer cells in response to chemotherapy (called therapy-induced senescence). Senescent cells can exert paracrine effects through the senescence-associated secretory phenotype (SASP) promoting cancer recurrence and ...
Jian-Wei Zhang, Dan Zhang, Hai-Sen Yin, Han Zhang, Kun-Qiao Hong, Jing-Ping Yuan, Bao-Ping Yu   +6 more
doaj   +1 more source

The SASP factor IL‐6 sustains cell‐autonomous senescent cells via a cGAS‐STING‐NFκB intracrine senescent noncanonical pathway

Aging Cell
Senescent cells produce a Senescence‐Associated Secretory Phenotype (SASP) that involves factors with diverse and sometimes contradictory activities. One key SASP factor, interleukin‐6 (IL‐6), has the potential to amplify cellular senescence in the SASP ...
Florencia Herbstein, Melanie Sapochnik, Alejandra Attorresi, C. Pollak, S. Senin, David Gonilski-Pacin, Nicolas Ciancio del Giudice, M. Fiz, Belén Elguero, Mariana Fuertes, Lara Müller, M. Theodoropoulou, Lucas B. Pontel, Eduardo Arzt   +13 more
semanticscholar   +1 more source