Results 71 to 80 of about 4,806,391 (287)

Holographic view of the senescent cells: Imagine all the senescent cells are not flattened

open access: yesThe FASEB Journal, 2017
Öz bulunamadı.
Simay, Yaprak Dilber   +3 more
openaire   +3 more sources

Senescent cells promote breast cancer cells motility by secreting GM-CSF and bFGF that activate the JNK signaling pathway

open access: yesCell Communication and Signaling
Background Cellular senescence can be induced in mammalian tissues by multiple stimuli, including aging, oncogene activation and loss of tumor suppressor genes, and various types of stresses. While senescence is a tumor suppressing mechanism when induced
Nan Wang   +12 more
doaj   +1 more source

Proteomic profiling of senescent human diploid fibroblasts treated with gamma-tocotrienol

open access: yesBMC Complementary and Alternative Medicine, 2018
Background Replicative senescence of human diploid fibroblasts (HDFs) has been used as a model to study mechanisms of cellular aging. Gamma-tocotrienol (γT3) is one of the members of vitamin E family which has been shown to increase proliferation of ...
Jen-Kit Tan   +2 more
doaj   +1 more source

Targeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane marker

open access: yesScientific Reports, 2021
A wide range of diseases have been shown to be influenced by the accumulation of senescent cells, from fibrosis to diabetes, cancer, Alzheimer’s and other age-related pathologies.
Marta Poblocka   +10 more
doaj   +1 more source

The Impact of the COVID‐19 Pandemic on Childhood Cancer Survival: A Population‐Based Assessment of Survival Patterns Between 2015 and 2023 in Germany

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann   +8 more
wiley   +1 more source

Proteomic analysis of senescent and non-senescent CHME-5 microglia.

open access: yes, 2019
In this experiment, senescent CHME-5 microglial cells were generated and their proteomes were compared to non-senescent CHME-5 microglial cells. Compared to non-senescent cells, a detailed proteomic analysis using SWATH-MS identified 201 proteins that ...
Marques, L (via Mendeley Data)   +1 more
core   +1 more source

Nanocarriers targeting senescent cells [PDF]

open access: yes, 2019
Ageing and multiple chronic diseases in humans associate with an aberrant accumulation of senescent cells in a diversity of tissues, which contributes to organ dysfunction and drives their pathological manifestations.

core   +2 more sources

Mechanisms of natural killer cell-mediated clearance of senescent renal tubular epithelial cells

open access: yesFrontiers in Cell and Developmental Biology
IntroductionIntact kidney function is essential for fluid and electrolyte homeostasis, with renal tubular epithelial cells providing critical functions in the reabsorption or secretion of numerous metabolites.
Nils David Funk   +11 more
doaj   +1 more source

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari   +5 more
wiley   +1 more source

Identification of novel therapeutic targets to selectively eliminate senescent cells in prostate cancer.

open access: yes, 2020
Despite recent progresses, prostate cancer (PC) is still the second most diagnosed cancer and the sixth leading cause of cancer death among men worldwide.
Montopoli Monica   +4 more
core  

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