Results 91 to 100 of about 12,101,411 (341)

Proteomic profiling of senescent human diploid fibroblasts treated with gamma-tocotrienol

BMC Complementary and Alternative Medicine, 2018
Background Replicative senescence of human diploid fibroblasts (HDFs) has been used as a model to study mechanisms of cellular aging. Gamma-tocotrienol (γT3) is one of the members of vitamin E family which has been shown to increase proliferation of ...
Jen-Kit Tan, Faizul Jaafar, Suzana Makpol   +2 more
doaj   +1 more source

A ganglioside-based immune checkpoint enables senescent cells to evade immunosurveillance during aging

Nature Aging
Although senescent cells can be eliminated by the immune system, they tend to accumulate with age in various tissues. Here we show that senescent cells can evade immune clearance by natural killer (NK) cells by upregulating the expression of the ...
C. Iltis, Iryna Moskalevska, Antoine Debiesse, Laetitia Seguin, Christina Fissoun, Ludovic Cervera, Lyvia Moudombi, M. Ardin, Anthony Ferrari, Coline Eliott, Didier F. Pisani, A. Ottaviani, Manon Bourinet, Carmelo Luci, Philippe Gual, Gabriela Makulyte, David Bernard, M. Durandy, Lou C. Duret, Tynhinane Hamidouche, Sarah Kunz, Oliver Croce, C. Delannoy, Yann Guérardel, Fabrice Allain, Paul Hofman, Delphine Benarroch-Popivker, Laurence Bianchini, B. Dadone-Montaudié, Estelle Cosson, J. Guglielmi, Thierry Pourcher, V. Braud, Marina Shkreli, Y. Pers, Christian Jorgensen, J. Brondello, C. Féral, M. Michallet, Eric Gilson, Julien Cherfils‐Vicini   +40 more
semanticscholar   +1 more source

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters, Ji Yun Tark, Tiffany M. Chambers, Tania A. Desrosiers, Michael E. Scheurer, Charles Shumate, Wendy N. Nembhard, Mahsa M. Yazdy, Eirini Nestoridi, Amanda E. Janitz, Jean Paul Tanner, Russell S. Kirby, Jason L. Salemi, Yao Yu, Chad D. Huff, Sharon E. Plon, Philip J. Lupo, Jeremy M. Schraw   +17 more
wiley   +1 more source

Identification of novel therapeutic targets to selectively eliminate senescent cells in prostate cancer.

, 2020
Despite recent progresses, prostate cancer (PC) is still the second most diagnosed cancer and the sixth leading cause of cancer death among men worldwide.
Montopoli Monica, Alimonti Andrea, Bressan Silvia, Zumerle Sara, Brina Daniela   +4 more
core  

Malignancy without immortality? Cellular immortalization as a possible late event in melanoma progression

, 2011
P>Cell senescence is a permanent growth arrest following extended proliferation. Cultured cancer cells including metastatic melanoma cells often appear immortal (proliferate indefinitely), while uncultured benign nevi (moles) show senescence markers ...
Marais, R., Marais, R, Bennett, DC, Julia K. Soo, Chow, J, Hill, L, Chow, J., Ross, ADM, W. Nicol Keith, MacKenzie Ross, A.D., Hossain, M., Bennett, D.C., Heung Chong, W, Hoare, S, Mehnaz Hossain, Soo, JK, Dorothy C. Bennett, Rebecca S. Collinson, Carla Milagre, Milagre, C., David M. Kallenberg, Lucy Hill, Collinson, RS, Mackenzie Ross, AD, Hill, L., Chong, WH, Richard Marais, Kallenberg, DM, Soo, J.K., Jade Chow, Keith, W.N., Hossain, M, Heung Chong, W., Hoare, S., Stacey Hoare, Kallenberg, D.M., Milagre, C, W. Heung Chong, Collinson, R.S., Keith, WN, Alastair D. MacKenzie Ross   +40 more
core   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Chemical Strategies for the Detection and Elimination of Senescent Cells

Accounts of Chemical Research
Conspectus Cellular senescence can be defined as an irreversible stopping of cell proliferation that arises in response to various stress signals. Cellular senescence is involved in diverse physiological and pathological processes in different tissues ...
Jessie García-Fleitas, A. García‐Fernández, Vicente Martí‐Centelles, F. Sancenón, A. Bernardos, R. Martínez‐Máñez   +5 more
semanticscholar   +1 more source

Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc Degeneration

Frontiers in Bioengineering and Biotechnology, 2022
Intervertebral disc degeneration (IVDD) is the main cause of cervical and lumbar spondylosis. Over the past few years, the relevance between cellular senescence and IVDD has been widely studied, and the senescence-associated secretory phenotype (SASP ...
Yuhao Wu, Shiwei Shen, Yifeng Shi, Naifeng Tian, Yifei Zhou, Xiaolei Zhang   +5 more
semanticscholar   +1 more source

Holographic view of the senescent cells: Imagine all the senescent cells are not flattened

The FASEB Journal, 2017
Öz bulunamadı.
Simay, Yaprak Dilber, Ozdemir, Aysun, Ibisoglu, Burcin, Ark, Mustafa   +3 more
openaire   +3 more sources

Nanocarriers targeting senescent cells

, 2019
Ageing and multiple chronic diseases in humans associate with an aberrant accumulation of senescent cells in a diversity of tissues, which contributes to organ dysfunction and drives their pathological manifestations.

core   +1 more source