Results 101 to 110 of about 12,101,411 (341)

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

Senescent cells promote breast cancer cells motility by secreting GM-CSF and bFGF that activate the JNK signaling pathway

Cell Communication and Signaling
Background Cellular senescence can be induced in mammalian tissues by multiple stimuli, including aging, oncogene activation and loss of tumor suppressor genes, and various types of stresses. While senescence is a tumor suppressing mechanism when induced
Nan Wang, Yan Fang, Yigong Hou, Dongmei Cheng, Emily V. Dressler, Hao Wang, Juan Wang, Guanwen Wang, Yilei Li, Hong Liu, Rong Xiang, Shuang Yang, Peiqing Sun   +12 more
doaj   +1 more source

Phagocytosis of aged human neutrophils by macrophages is mediated by a novel "charge-sensitive" recognition mechanism

, 1989
The removal of neutrophils and their histotoxic contents from the inflamed site is a prerequisite for resolution of tissue injury, and a point at which factors critical to the pathogenesis of chronic inflammation may act.
Savill, John S, J S Savill, Henson, P M, P M Henson, C Haslett, Haslett, Christopher   +5 more
core   +1 more source

Effects of the Fluid Replacement Method During Online Hemodiafiltration on the Solute Removal Performance and Biocompatibility Using the Asymmetric Cellulose Triacetate Membrane

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Pre‐dilution online hemodiafiltration (Pre‐HDF) is predominantly used in Japan, whereas post‐dilution online HDF (Post‐HDF) is more common in Europe. An asymmetric cellulose triacetate (ATA) membrane may improve biocompatibility.
Kenji Sakurai, Yoshitaka Kurihara, Fumi Yamauchi, Hiromi Hosoya, Takeshi Saito   +4 more
wiley   +1 more source

Mechanisms of natural killer cell-mediated clearance of senescent renal tubular epithelial cells

Frontiers in Cell and Developmental Biology
IntroductionIntact kidney function is essential for fluid and electrolyte homeostasis, with renal tubular epithelial cells providing critical functions in the reabsorption or secretion of numerous metabolites.
Nils David Funk, Julius Sinning, Patrick Schaser, Patrick Schaser, Inga Soerensen-Zender, Vera Christine Wulfmeyer, Kai Schmidt-Ott, Korbinian Brand, Stephan Halle, Stephan Halle, Roland Schmitt, Roland Schmitt   +11 more
doaj   +1 more source

Functional restoration of replicative senescent mesenchymal stem cells by the brown alga Undaria pinnatifida

, 2017
The brown alga Undaria pinnatifida, which is called Mi-Yoek in Korea, has been traditionally consumed as a health food in East Asian countries. Recent studies have reported that U. pinnatifida has beneficial effects on arteriosclerosis, inflammation, fat
Joe, I-Seul, Youn Seo Oh, Cho, Goang-Won, Cho, Hyo Moon, Hyo Moon Cho, Jeong, Sin-Gu, Cho, Tae Oh, So Young Jeong, 오원근, Oh, Youn Seo, Won Keun Oh, Goang-Won Cho, Lee, Jun Sik, I-Seul Joe, Sin-Gu Jeong, Tae Oh Cho, Oh, Won Keun, Jun Sik Lee, Jeong, So Young   +18 more
core   +1 more source

Biomarkers to identify and isolate senescent cells. [PDF]

, 2016
Aging is the main risk factor for many degenerative diseases and declining health. Senescent cells are part of the underlying mechanism for time-dependent tissue dysfunction.
Ethan Anders Sarnoski (7215461), Alexandra Stolzing (1251348), Greg Chin (7215458), Mantas Matjusaitis (3946805)   +3 more
core   +1 more source

Simvastatin suppresses breast cancer cell proliferation induced by senescent cells [PDF]

, 2015
Cellular senescence suppresses cancer by preventing the proliferation of damaged cells, but senescent cells can also promote cancer though the pro-inflammatory senescence-associated secretory phenotype (SASP). Simvastatin, an HMG-coA reductase inhibitor,
Desprez, Pierre-Yves, Campisi, Judith, Kapahi, Pankaj, Liu, Su, Demaria, Marco, Uppal, Harpreet   +5 more
core   +1 more source

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source

Leveraging Senescent Cancer Cell Membrane to Potentiate Cancer Immunotherapy Through Biomimetic Nanovaccine

Advanced Science
Senescent cancer cells are endowed with high immunogenic potential that has been leveraged to elicit antitumor immunity and potentially complement anticancer therapies.
Chao Yang, Yinglu Chen, Jie Liu, Wensheng Zhang, Yan He, Fangman Chen, Xiaochun Xie, Jie Tang, Shan Guan, Dan Shao, Zheng Wang, Liang Wang   +11 more
doaj   +1 more source