Results 111 to 120 of about 12,101,411 (341)

Senescent cell accumulation is associated with T-cell imbalance in the skin

Вавиловский журнал генетики и селекции
Organismal aging is accompanied by the accumulation of senescent cells – damaged, non-functional cells that exhibit cell cycle arrest, resistance to apoptosis, metabolic dysfunction, and production of a wide range of pro-inflammatory substances.
K. S. Matveeva, S. K. Kolmykov, T. S. Sokolova, D. R. Salimov, D. V. Shevyrev   +4 more
doaj   +1 more source

Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages

Nature Metabolism, 2020
Declining tissue nicotinamide adenine dinucleotide (NAD) levels are linked to ageing and its associated diseases. However, the mechanism for this decline is unclear. Here, we show that pro-inflammatory M1-like macrophages, but not naive or M2 macrophages,
Anthony J. Covarrubias, Abhijit Kale, Rosalba Perrone, J. López-Domínguez, A. Pisco, H. Kasler, Mark S. Schmidt, I. Heckenbach, Ryan Kwok, Christopher D. Wiley, H. Wong, Eddy Gibbs, S. Iyer, N. Basisty, Qiuxia Wu, Ikjung Kim, Elena Silva, Kaitlyn Vitangcol, Kyong-Oh Shin, Yong-Moon Lee, R. Riley, I. Ben-Sahra, M. Ott, B. Schilling, M. Scheibye-Knudsen, K. Ishihara, S. Quake, John C. Newman, C. Brenner, J. Campisi, E. Verdin   +30 more
semanticscholar   +1 more source

Possible immunotherapies targeting senescent cells.

, 2018
immunotherapy targeting senescent ...
Dominick Burton (607957)
core   +1 more source

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye, Chimezie Okwuonu, Evelyn Idam, Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Zinnah Aloziem, Blossom Amamchukwu, Patience Elimia, Mkpoikanabasi Obot‐Obot, Henry Mbakwe, Praises Maduagwuna, Olatunji Akinrodoye, Chiamaka Anyanwu, Benjamin Anyanwu, Adedamola Akinsiku, Oluwatoyin A. Akinsiku, Muzamil O. Hassan, Fatiu A. Arogundade, Olalekan E. Ojo, Homayemem Weli, Jesupelumi Adenihun, Aderemi Adelaja, Ebun Bamgboye, Olalekan Olatise, Ade E. Faponle, Ayoola Odeyemi, Michael Muoka, Stephen Asaolu, Qudrat Busari, Blessing Dawudu, Michael Naiyeju, Rasheed A. Balogun   +33 more
wiley   +1 more source

Senescence in the aging process [version 1; referees: 3 approved]

F1000Research, 2017
The accumulation of ‘senescent’ cells has long been proposed to act as an ageing mechanism. These cells display a radically altered transcriptome and degenerative phenotype compared with their growing counterparts.
Richard GA Faragher, Anne McArdle, Alison Willows, Elizabeth L. Ostler   +3 more
doaj   +1 more source

A BDNF-TrkB autocrine loop enhances senescent cell viability

Nature Communications, 2022
Selective elimination of senescent cells is an approach that has shown promise to ameliorate age-associated pathologies in preclinical models. Here the authors report that BDNF enhances senescent cell viability via TrkB in cultured cells, and that TrkB ...
Carlos Anerillas, Allison B. Herman, Rachel Munk, Amanda Garrido, Kwan-Wood Gabriel Lam, Matthew J. Payea, Martina Rossi, Dimitrios Tsitsipatis, Jennifer L. Martindale, Yulan Piao, Krystyna Mazan-Mamczarz, Jinshui Fan, Chang-Yi Cui, Supriyo De, Kotb Abdelmohsen, Rafael de Cabo, Myriam Gorospe   +16 more
doaj   +1 more source

Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

Cell, 2017
Summary The accumulation of irreparable cellular damage restricts healthspan after acute stress or natural aging. Senescent cells are thought to impair tissue function and their genetic clearance can delay features of aging.
M. Baar, Renata M. C. Brandt, D. Putavet, Julian D. D. Klein, K. Derks, Benjamin Bourgeois, Sarah Stryeck, Y. Rijksen, Hester van Willigenburg, D. Feijtel, I. van der Pluijm, J. Essers, W. V. van Cappellen, W. V. van Ijcken, A. Houtsmuller, J. Pothof, R. de Bruin, T. Madl, J. Hoeijmakers, J. Campisi, Peter L.J. de Keizer   +20 more
semanticscholar   +1 more source

Senescent tumor cells lead the collective invasion in thyroid cancer

, 2022
Cellular senescence has been perceived as a barrier against carcinogenesis. However, the senescence-associated secretory phenotype (SASP) of senescent cells can promote tumorigenesis.
Soh, Euy Young, Lee, Ga Yeon, Kim, Young Hwa, Park, Tae Jun, Kim, Jang Hee, Choi, Yong Won, Lee, Jeonghun   +6 more
core  

Experience With Performing Rheocarna Therapy via the Single‐Needle Method for Treatment of Chronic Limb‐Threatening Ischemia

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi, Rie Tanaka, Reona Kawahira, Shingo Nabeta, Kouhei Naoi, Kazuhito Kitajima, Akira Wada, Tomonari Takagi, Norihiko Ohura, Akira Miyamoto   +9 more
wiley   +1 more source

Cell fusion induced senescence

Aging, 2014
Cellular senescence has long been established as a stable and irreversible growth arrest, which plays an important role in tumor suppression and tissue repair. It can be induced by various stimuli, including telomere shortening, oncogene activation and oxidative stress. We recently demonstrated that cell-cell fusion is a previously unidentified trigger
Hilah, Gal, Valery, Krizhanovsky
openaire   +2 more sources