Results 31 to 40 of about 12,101,411 (341)

Emerging Therapeutic Approaches to Target the Dark Side of Senescent Cells: New Hopes to Treat Aging as a Disease and to Delay Age-Related Pathologies

Cells, 2023
Life expectancy has drastically increased over the last few decades worldwide, with important social and medical burdens and costs. To stay healthy longer and to avoid chronic disease have become essential issues.
Roula Khalil, M. Diab‐Assaf, J. Lemaître   +2 more
semanticscholar   +1 more source

PDK4-dependent hypercatabolism and lactate production of senescent cells promotes cancer malignancy

Nature Metabolism, 2023
Senescent cells remain metabolically active, but their metabolic landscape and resulting implications remain underexplored. Here, we report upregulation of pyruvate dehydrogenase kinase 4 (PDK4) upon senescence, particularly in some stromal cell lines ...
X. Dou, Q. Fu, Q. Long, Shuning Liu, Yejun Zou, Daguang Fu, Qixia Xu, Zhirui Jiang, Xiaohui Ren, Guilong Zhang, Xiaoling Wei, Qingfeng Li, Judith Campisi, Yuzheng Zhao, Yu Sun   +14 more
semanticscholar   +1 more source

Biomaterials targeting senescent cells for bone regeneration: State-of-the-art and future perspectives. [PDF]

Bioact Mater
Bone defect treatment remains a significant clinical challenge, further exacerbated by the demographic transition toward an aging society. In elderly populations, the increased proportion of senescent cells emerges as a fundamental determinant that ...
Wu H, Zhang Q, Zhu J, Wu L, Xiao Y, Yang X.   +5 more
europepmc   +2 more sources

Senescent vs. non-senescent cells in the human annulus in vivo: Cell harvest with laser capture microdissection and gene expression studies with microarray analysis

BMC Biotechnology, 2010
Background Senescent cells are well-recognized in the aging/degenerating human disc. Senescent cells are viable, cannot divide, remain metabolically active and accumulate within the disc over time. Molecular analysis of senescent cells in tissue offers a
Ingram Jane A, Hoelscher Gretchen L, Gruber Helen E, Zinchenko Natalia, Hanley Edward N   +4 more
doaj   +1 more source

Carnosine Stimulates Macrophage-Mediated Clearance of Senescent Skin Cells Through Activation of the AKT2 Signaling Pathway by CD36 and RAGE

Frontiers in Pharmacology, 2020
Background: Macrophages can selectively recognize and eliminate senescent cells, but this function is impaired with age, resulting in excessive accumulation of senescent cells in the skin, which ultimately causes skin aging.
Xuenan Li, Kaiye Yang, Shuang Gao, Jungang Zhao, Guangrong Liu, Yu Chen, Haojie Lin, Wengang Zhao, Zhenlin Hu, Nuo Xu   +9 more
doaj   +1 more source

Cellular senescence enhances adaptive anticancer immunosurveillance

OncoImmunology, 2023
Cancer therapy often induces senescence in some cancer cells. Senescent cells, due to their profoundly altered biology, may conceivably interact with the adaptive immune system in novel ways that may boost cancer immunosurveillance, triggering the ...
Ines Marin, Manuel Serrano, Federico Pietrocola   +2 more
doaj   +1 more source

Strategies for Targeting Senescent Cells in Human Disease

Nature Aging, 2021
Cellular senescence represents a distinct cell fate characterized by replicative arrest in response to a host of extrinsic and intrinsic stresses. Senescence facilitates programming during development and wound healing, while limiting tumorigenesis ...
Nathan S. Gasek, G. Kuchel, J. Kirkland, Ming Xu   +3 more
semanticscholar   +1 more source

Executing Cell Senescence [PDF]

Cell Cycle, 2004
Senescence is a permanent form of cell cycle arrest that limits the proliferation of damaged cells and may contribute to tumor suppression and aging. We recently demonstrated that some senescent cell types undergo dramatic changes in chromatin organization that are dependent on the retinoblastoma protein and are associated with the stable repression of
Masashi, Narita, Scott W, Lowe
openaire   +2 more sources

Piperine: An Anticancer and Senostatic Drug

Frontiers in Bioscience-Landmark, 2022
Background: Cancer is a representative geriatric disease closely related to senescent cells and cell aging in tissues. Senescent cells that surround cancer tissues reduce the effects of various cancer treatments and induce cancer recurrence through ...
Jae Sung Lim, Da Young Lee, Ju Hyeon Lim, Won Keun Oh, Jun Tae Park, Sang Chul Park, Kyung A Cho   +6 more
doaj   +1 more source

Rutin is a potent senomorphic agent to target senescent cells and can improve chemotherapeutic efficacy

Aging Cell, 2023
Aging is a major risk factor for most chronic disorders, for which cellular senescence is one of the central hallmarks. Senescent cells develop the pro‐inflammatory senescence‐associated secretory phenotype (SASP), which significantly contributes to ...
Hanxin Liu, Qixia Xu, Halidan Wufuer, Zi Li, Rong Sun, Zhirui Jiang, X. Dou, Q. Fu, J. Campisi, Yu Sun   +9 more
semanticscholar   +1 more source