Similarities and interplay between senescent cells and macrophages [PDF]
, 2020 Senescence is a cellular program that prevents the replication of old, damaged, or cancerous cells. Senescent cells become growth arrested and undergo changes in their morphology, chromatin organization, and metabolism, and produce a bioactive secretome.
Jesús Gil +3 more
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Senescent Cells Impair Erectile Function through Induction of Endothelial Dysfunction and Nerve Injury in Mice. [PDF]
PLoS ONE, 2015 Erectile dysfunction (ED) is a major health problem, particularly in the elderly population, which is rapidly increasing. It is necessary to elucidate the mechanism by which ED occurs in the elderly.
Hiroaki Nishimatsu +7 more
doaj +1 more source
p15INK4B is an alternative marker of senescent tumor cells in colorectal cancer
Heliyon, 2023 Senescent tumor cells are nonproliferating tumor cells which are closely related to cancer progression by secreting senescence-related molecules, called senescence-associated secreting phenotypes.
Soon Sang Park +8 more
doaj +1 more source
The development of cell senescence
Experimental Gerontology, 2019 Cellular senescence was traditionally considered a stress response that protected the organism by limiting the proliferation of damaged and unwanted cells. However, the recent identification of developmentally-programmed cellular senescence during embryo development has changed our view of the process.
Sabela, Da Silva-Álvarez +6 more
openaire +2 more sources
Lipophilic Statins Eliminate Senescent Endothelial Cells by inducing Anoikis-Related Cell Death
, 2023 Pre-clinical studies from the recent past have indicated that senescent cells can negatively affect health and contribute to premature aging. Targeted eradication of these cells has been shown to improve the health of aged experimental animals, leading ...
Shafaat Y. Khan +11 more
core +1 more source
Cell senescence, the senescence-associated secretory phenotype, and cancers
PLOS Biology, 2023 Cellular senescence is a cell fate caused by multiple stresses. A 2008 article in PLOS Biology reported a senescence-associated secretory phenotype that can promote inflammation and cancer, eventually enabling the development of senolytic drugs.
Larissa G. P. Langhi Prata +2 more
openaire +3 more sources
The Senolytic Drug JQ1 Removes Senescent Cells via Ferroptosis
, 2021 BACKGROUND: Ferroptosis is an iron-dependent, non-apoptotic programmed cell death. Cellular senescence contributes to aging and various age-related diseases through the expression of a senescence-associated secretory phenotype (SASP). Senescent cells are
Go, Seokhyeong +12 more
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The lysosomal proteome of senescent cells contributes to the senescence secretome
Aging Cell, 2022 AbstractSenescent cells accumulate in tissues over time, favoring the onset and progression of multiple age‐related diseases. Senescent cells present a remarkable increase in lysosomal mass and elevated autophagic activity. Here, we report that two main autophagic pathways macroautophagy (MA) and chaperone‐mediated autophagy (CMA) are constitutively ...
Miguel Rovira +11 more
openaire +5 more sources
Cellular senescence primes liver fibrosis regression through Notch‐EZH2
MedComm, 2023 Cellular senescence plays a pivotal role in wound healing. At the initiation of liver fibrosis regression, accumulated senescent cells were detected and genes of senescence were upregulated.
Ping Song +12 more
doaj +1 more source
Flow Cytometry-based Method for Efficient Sorting of Senescent Cells
Bio-Protocol, 2023 Cellular senescence is a reprogrammed cell state triggered as an adaptative response to a variety of stresses, most often those affecting the genome integrity.
Erwan Goy +12 more
doaj +1 more source