Results 31 to 40 of about 4,484,629 (285)
From the divergence of senescent cell fates to mechanisms and selectivity of senolytic drugs
Open Biology, 2022 Senescence is a cellular stress response that involves prolonged cell survival, a quasi-irreversible proliferative arrest and a modification of the transcriptome that sometimes includes inflammatory gene expression.
Valentin L'Hôte +2 more
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Scientific Reports, 2022 Characteristics of cell migration in a confluent population depend on the nature of cell-to-cell interactions as well as cell-intrinsic properties such as the directional persistence in crawling.
Thamara Liz Gabuardi +2 more
doaj +1 more source
Flow Cytometry-based Method for Efficient Sorting of Senescent Cells
Bio-Protocol, 2023 Cellular senescence is a reprogrammed cell state triggered as an adaptative response to a variety of stresses, most often those affecting the genome integrity.
Erwan Goy +12 more
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The development of cell senescence
Experimental Gerontology, 2019 Cellular senescence was traditionally considered a stress response that protected the organism by limiting the proliferation of damaged and unwanted cells. However, the recent identification of developmentally-programmed cellular senescence during embryo development has changed our view of the process.
Sabela, Da Silva-Álvarez +6 more
openaire +2 more sources
Cell senescence, the senescence-associated secretory phenotype, and cancers
PLOS Biology, 2023 Cellular senescence is a cell fate caused by multiple stresses. A 2008 article in PLOS Biology reported a senescence-associated secretory phenotype that can promote inflammation and cancer, eventually enabling the development of senolytic drugs.
Larissa G. P. Langhi Prata +2 more
openaire +3 more sources
Cellular senescence primes liver fibrosis regression through Notch‐EZH2
MedComm, 2023 Cellular senescence plays a pivotal role in wound healing. At the initiation of liver fibrosis regression, accumulated senescent cells were detected and genes of senescence were upregulated.
Ping Song +12 more
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The lysosomal proteome of senescent cells contributes to the senescence secretome
Aging Cell, 2022 AbstractSenescent cells accumulate in tissues over time, favoring the onset and progression of multiple age‐related diseases. Senescent cells present a remarkable increase in lysosomal mass and elevated autophagic activity. Here, we report that two main autophagic pathways macroautophagy (MA) and chaperone‐mediated autophagy (CMA) are constitutively ...
Miguel Rovira +11 more
openaire +5 more sources
Ring-like distribution of constitutive heterochromatin in bovine senescent cells. [PDF]
PLoS ONE, 2011 BACKGROUND: Cells that reach "Hayflick limit" of proliferation, known as senescent cells, possess a particular type of nuclear architecture. Human senescent cells are characterized by the presence of highly condensed senescent associated heterochromatin ...
Andrey Pichugin +3 more
doaj +1 more source
Targeting senescent cell clearance: An approach to delay aging and age-associated disorders
Translational Medicine of Aging, 2021 Cellular senescence is the occurrence of irreversible cell cycle arrest resulting from accumulated DNA damage and the loss of proteostasis over time. Senescent cells contribute to age-related diseases and aging itself. Therefore, the targeted elimination
Zhengqi Qiu +5 more
doaj +1 more source
Senescent Cells: A Therapeutic Target in Cardiovascular Diseases
, 2023 Senescent cell accumulation has been observed in age-associated diseases including cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence-associated secretory phenotype (SASP) factors that may cause or worsen many ...
Georgina M. Ellison-Hughes +7 more
core +1 more source