Results 21 to 30 of about 112,157 (308)
Bone marrow senescence and the microenvironment of hematological malignancies [PDF]
, 2020 Senescence is the irreversible arrest of cell proliferation that has now been shown to play an important role in both health and disease. With increasing age senescent cells accumulate throughout the body, including the bone marrow and this has been ...
Bowles, Kristian M. +3 more
core +1 more source
Controlling secretion to limit chemoresistance [PDF]
, 2016 The tumor microenvironment influences cancer progression and therapy outcome by mechanisms not yet fully understood. In this issue, Bent et al. (2016) show how chemotherapy causes endothelial senescence.
Georgilis, A, Gil, J
core +1 more source
Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer
Nature Communications, 2022 Cells subjected to treatment with anti-cancer therapies can evade apoptosis through cellular senescence. Persistent senescent tumor cells remain metabolically active, possess a secretory phenotype, and can promote tumor proliferation and metastatic ...
Martina Troiani +14 more
doaj +1 more source
Piperine: An Anticancer and Senostatic Drug
Frontiers in Bioscience-Landmark, 2022 Background: Cancer is a representative geriatric disease closely related to senescent cells and cell aging in tissues. Senescent cells that surround cancer tissues reduce the effects of various cancer treatments and induce cancer recurrence through ...
Jae Sung Lim +6 more
doaj +1 more source
Targeting senescent cells enhances adipogenesis and metabolic function in old age
eLife, 2015 Senescent cells accumulate in fat with aging. We previously found genetic clearance of senescent cells from progeroid INK-ATTAC mice prevents lipodystrophy.
Ming Xu +13 more
doaj +1 more source
Senescent Cells Impair Erectile Function through Induction of Endothelial Dysfunction and Nerve Injury in Mice. [PDF]
PLoS ONE, 2015 Erectile dysfunction (ED) is a major health problem, particularly in the elderly population, which is rapidly increasing. It is necessary to elucidate the mechanism by which ED occurs in the elderly.
Hiroaki Nishimatsu +7 more
doaj +1 more source
p15INK4B is an alternative marker of senescent tumor cells in colorectal cancer
Heliyon, 2023 Senescent tumor cells are nonproliferating tumor cells which are closely related to cancer progression by secreting senescence-related molecules, called senescence-associated secreting phenotypes.
Soon Sang Park +8 more
doaj +1 more source
Cell Senescence in Lupus [PDF]
Current Rheumatology Reports, 2019 The concept of cellular senescence has been evolving. Although originally proposed based on studies of serum-driven replication of cell lines in vitro, it is now clear that cellular senescence occurs in vivo. It has also become clear that cellular senescence can be triggered by a number of stimuli such as radiation, chemotherapy, activation of ...
Lin, Gao +5 more
openaire +2 more sources
Scientific Reports, 2022 Characteristics of cell migration in a confluent population depend on the nature of cell-to-cell interactions as well as cell-intrinsic properties such as the directional persistence in crawling.
Thamara Liz Gabuardi +2 more
doaj +1 more source
From the divergence of senescent cell fates to mechanisms and selectivity of senolytic drugs
Open Biology, 2022 Senescence is a cellular stress response that involves prolonged cell survival, a quasi-irreversible proliferative arrest and a modification of the transcriptome that sometimes includes inflammatory gene expression.
Valentin L'Hôte +2 more
doaj +1 more source