Results 21 to 30 of about 4,484,629 (285)

Senescent vs. non-senescent cells in the human annulus in vivo: Cell harvest with laser capture microdissection and gene expression studies with microarray analysis

BMC Biotechnology, 2010
Background Senescent cells are well-recognized in the aging/degenerating human disc. Senescent cells are viable, cannot divide, remain metabolically active and accumulate within the disc over time. Molecular analysis of senescent cells in tissue offers a
Ingram Jane A, Hoelscher Gretchen L, Gruber Helen E, Zinchenko Natalia, Hanley Edward N   +4 more
doaj   +1 more source

Carnosine Stimulates Macrophage-Mediated Clearance of Senescent Skin Cells Through Activation of the AKT2 Signaling Pathway by CD36 and RAGE

Frontiers in Pharmacology, 2020
Background: Macrophages can selectively recognize and eliminate senescent cells, but this function is impaired with age, resulting in excessive accumulation of senescent cells in the skin, which ultimately causes skin aging.
Xuenan Li, Kaiye Yang, Shuang Gao, Jungang Zhao, Guangrong Liu, Yu Chen, Haojie Lin, Wengang Zhao, Zhenlin Hu, Nuo Xu   +9 more
doaj   +1 more source

A Senescence Bystander Effect in Human Lung Fibroblasts

Biomedicines, 2021
Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterised by a dense fibrosing of the lung parenchyma. An association between IPF and cellular senescence is well established and several studies now describe a higher abundance of senescent ...
David W. Waters, Michael Schuliga, Prabuddha S. Pathinayake, Lan Wei, Hui-Ying Tan, Kaj E. C. Blokland, Jade Jaffar, Glen P. Westall, Janette K. Burgess, Cecilia M. Prêle, Steven E. Mutsaers, Christopher L. Grainge, Darryl A. Knight   +12 more
doaj   +1 more source

Functional Features of Senescent Cells and Implications for Therapy [PDF]

International Journal of Molecular Sciences
Roman Deev, Huiming Hua, Tatiana Kirichenko   +2 more
exaly   +2 more sources

Executing Cell Senescence [PDF]

Cell Cycle, 2004
Senescence is a permanent form of cell cycle arrest that limits the proliferation of damaged cells and may contribute to tumor suppression and aging. We recently demonstrated that some senescent cell types undergo dramatic changes in chromatin organization that are dependent on the retinoblastoma protein and are associated with the stable repression of
Masashi, Narita, Scott W, Lowe
openaire   +2 more sources

Piperine: An Anticancer and Senostatic Drug

Frontiers in Bioscience-Landmark, 2022
Background: Cancer is a representative geriatric disease closely related to senescent cells and cell aging in tissues. Senescent cells that surround cancer tissues reduce the effects of various cancer treatments and induce cancer recurrence through ...
Jae Sung Lim, Da Young Lee, Ju Hyeon Lim, Won Keun Oh, Jun Tae Park, Sang Chul Park, Kyung A Cho   +6 more
doaj   +1 more source

Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer

Nature Communications, 2022
Cells subjected to treatment with anti-cancer therapies can evade apoptosis through cellular senescence. Persistent senescent tumor cells remain metabolically active, possess a secretory phenotype, and can promote tumor proliferation and metastatic ...
Martina Troiani, Manuel Colucci, Mariantonietta D’Ambrosio, Ilaria Guccini, Emiliano Pasquini, Angelica Varesi, Aurora Valdata, Simone Mosole, Ajinkya Revandkar, Giuseppe Attanasio, Andrea Rinaldi, Anna Rinaldi, Marco Bolis, Pietro Cippà, Andrea Alimonti   +14 more
doaj   +1 more source

Cellular senescence enhances adaptive anticancer immunosurveillance

OncoImmunology, 2023
Cancer therapy often induces senescence in some cancer cells. Senescent cells, due to their profoundly altered biology, may conceivably interact with the adaptive immune system in novel ways that may boost cancer immunosurveillance, triggering the ...
Ines Marin, Manuel Serrano, Federico Pietrocola   +2 more
doaj   +1 more source

Targeting senescent cells enhances adipogenesis and metabolic function in old age

eLife, 2015
Senescent cells accumulate in fat with aging. We previously found genetic clearance of senescent cells from progeroid INK-ATTAC mice prevents lipodystrophy.
Ming Xu, Allyson K Palmer, Husheng Ding, Megan M Weivoda, Tamar Pirtskhalava, Thomas A White, Anna Sepe, Kurt O Johnson, Michael B Stout, Nino Giorgadze, Michael D Jensen, Nathan K LeBrasseur, Tamar Tchkonia, James L Kirkland   +13 more
doaj   +1 more source

Senescent Cells Impair Erectile Function through Induction of Endothelial Dysfunction and Nerve Injury in Mice. [PDF]

PLoS ONE, 2015
Erectile dysfunction (ED) is a major health problem, particularly in the elderly population, which is rapidly increasing. It is necessary to elucidate the mechanism by which ED occurs in the elderly.
Hiroaki Nishimatsu, Etsu Suzuki, Yasuho Saito, Aya Niimi, Akira Nomiya, Hiroshi Fukuhara, Haruki Kume, Yukio Homma   +7 more
doaj   +1 more source