Results 21 to 30 of about 12,101,411 (341)
Targeting cellular senescence in metabolic disease
Molecular Metabolism, 2022 Cellular senescence is a cell fate involving cell cycle arrest, resistance against apoptosis, and the development of a secretome that can be pro-inflammatory.
Allyson K. Palmer +2 more
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A senescent cell bystander effect: senescence‐induced senescence [PDF]
Aging Cell, 2012 SummarySenescent cells produce and secrete various bioactive molecules including interleukins, growth factors, matrix‐degrading enzymes and reactive oxygen species (ROS). Thus, it has been proposed that senescent cells can damage their local environment, and a stimulatory effect on tumour cell growth and invasiveness has been documented.
Nelson G +6 more
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A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
Nature Communications, 2021 Although cellular senescence drives multiple age-related co-morbidities through the senescence-associated secretory phenotype, in vivo senescent cell identification remains challenging.
D. Saul +18 more
semanticscholar +1 more source
International Journal of Oral Science, 2023 In dentistry, orthodontic root resorption is a long-lasting issue with no effective treatment strategy, and its mechanisms, especially those related to senescent cells, remain largely unknown.
Yue Zhou +9 more
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Cell Senescence in Lupus [PDF]
Current Rheumatology Reports, 2019 The concept of cellular senescence has been evolving. Although originally proposed based on studies of serum-driven replication of cell lines in vitro, it is now clear that cellular senescence occurs in vivo. It has also become clear that cellular senescence can be triggered by a number of stimuli such as radiation, chemotherapy, activation of ...
Lin, Gao +5 more
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Senescent Cell Depletion Through Targeting BCL-Family Proteins and Mitochondria
Frontiers in Physiology, 2020 Senescent cells with replicative arrest can be generated during genotoxic, oxidative, and oncogenic stress. Long-term retention of senescent cells in the body, which is attributed to highly expressed BCL-family proteins, chronically damages tissues ...
Ying Fan +9 more
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Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases
Cells, 2020 Senescent cells are generally characterized by permanent cell cycle arrest, metabolic alteration and activation, and apoptotic resistance in multiple organs due to various stressors.
Ping Song, Junqing An, Ming-Hui Zou
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Identification of gingerenone A as a novel senolytic compound.
PLoS ONE, 2022 Senescent cells accumulate with aging and have been shown to contribute to age-associated diseases and organ dysfunction. Eliminating senescent cells with senolytic drugs has been shown to improve age phenotypes in mouse models and there is some initial ...
Ruin Moaddel +7 more
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A versatile method for the identification of senolytic compounds
Cell Stress, 2023 The increased burden of senescent cells is as a well-established hallmark of aging and age-related diseases. This finding sparked significant interest in the identification of molecules capable of selectively eliminating senescent cells, so-called ...
Chiara Annunziata +8 more
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A Senescence Bystander Effect in Human Lung Fibroblasts
Biomedicines, 2021 Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterised by a dense fibrosing of the lung parenchyma. An association between IPF and cellular senescence is well established and several studies now describe a higher abundance of senescent ...
David W. Waters +12 more
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