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Frontiers in Pharmacology, 2020 Background: Macrophages can selectively recognize and eliminate senescent cells, but this function is impaired with age, resulting in excessive accumulation of senescent cells in the skin, which ultimately causes skin aging.
Xuenan Li +9 more
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Executing Cell Senescence [PDF]
Cell Cycle, 2004 Senescence is a permanent form of cell cycle arrest that limits the proliferation of damaged cells and may contribute to tumor suppression and aging. We recently demonstrated that some senescent cell types undergo dramatic changes in chromatin organization that are dependent on the retinoblastoma protein and are associated with the stable repression of
Masashi, Narita, Scott W, Lowe
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The effect of radiation on cellular ageing [PDF]
, 2012 This thesis was submitted for the degree of Master of Philosophy and awarded by Brunel UniversityHumans are exposed to low and moderate doses of ionising radiation (IR) from a range of diagnostic and occupational sources which may lead to cellular ...
Sabin, Rebecca Jane
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Cellular senescence enhances adaptive anticancer immunosurveillance
OncoImmunology, 2023 Cancer therapy often induces senescence in some cancer cells. Senescent cells, due to their profoundly altered biology, may conceivably interact with the adaptive immune system in novel ways that may boost cancer immunosurveillance, triggering the ...
Ines Marin +2 more
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Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer
Nature Communications, 2022 Cells subjected to treatment with anti-cancer therapies can evade apoptosis through cellular senescence. Persistent senescent tumor cells remain metabolically active, possess a secretory phenotype, and can promote tumor proliferation and metastatic ...
Martina Troiani +14 more
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Piperine: An Anticancer and Senostatic Drug
Frontiers in Bioscience-Landmark, 2022 Background: Cancer is a representative geriatric disease closely related to senescent cells and cell aging in tissues. Senescent cells that surround cancer tissues reduce the effects of various cancer treatments and induce cancer recurrence through ...
Jae Sung Lim +6 more
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Senescent Cells: A Therapeutic Target in Cardiovascular Diseases
, 2023 Senescent cell accumulation has been observed in age-associated diseases including cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence-associated secretory phenotype (SASP) factors that may cause or worsen many ...
Georgina M. Ellison-Hughes +7 more
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Targeting senescent cells enhances adipogenesis and metabolic function in old age
eLife, 2015 Senescent cells accumulate in fat with aging. We previously found genetic clearance of senescent cells from progeroid INK-ATTAC mice prevents lipodystrophy.
Ming Xu +13 more
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From the divergence of senescent cell fates to mechanisms and selectivity of senolytic drugs
Open Biology, 2022 Senescence is a cellular stress response that involves prolonged cell survival, a quasi-irreversible proliferative arrest and a modification of the transcriptome that sometimes includes inflammatory gene expression.
Valentin L'Hôte +2 more
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Scientific Reports, 2022 Characteristics of cell migration in a confluent population depend on the nature of cell-to-cell interactions as well as cell-intrinsic properties such as the directional persistence in crawling.
Thamara Liz Gabuardi +2 more
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