Results 11 to 20 of about 4,806,391 (287)
Targeting cellular senescence in metabolic disease
Molecular Metabolism, 2022 Cellular senescence is a cell fate involving cell cycle arrest, resistance against apoptosis, and the development of a secretome that can be pro-inflammatory.
Allyson K. Palmer +2 more
doaj +1 more source
Cell Senescence in Lupus [PDF]
Current Rheumatology Reports, 2019 The concept of cellular senescence has been evolving. Although originally proposed based on studies of serum-driven replication of cell lines in vitro, it is now clear that cellular senescence occurs in vivo. It has also become clear that cellular senescence can be triggered by a number of stimuli such as radiation, chemotherapy, activation of ...
Lin, Gao +5 more
openaire +2 more sources
International Journal of Oral Science, 2023 In dentistry, orthodontic root resorption is a long-lasting issue with no effective treatment strategy, and its mechanisms, especially those related to senescent cells, remain largely unknown.
Yue Zhou +9 more
doaj +1 more source
Senescent Cell Depletion Through Targeting BCL-Family Proteins and Mitochondria
Frontiers in Physiology, 2020 Senescent cells with replicative arrest can be generated during genotoxic, oxidative, and oncogenic stress. Long-term retention of senescent cells in the body, which is attributed to highly expressed BCL-family proteins, chronically damages tissues ...
Ying Fan +9 more
doaj +1 more source
Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases
Cells, 2020 Senescent cells are generally characterized by permanent cell cycle arrest, metabolic alteration and activation, and apoptotic resistance in multiple organs due to various stressors.
Ping Song, Junqing An, Ming-Hui Zou
doaj +1 more source
The Immunogenicity of Human Senescent Cells Is Dependent on the Senescence Inducer and Cell Type. [PDF]
Aging CellABSTRACT Senescent cells accumulate with age and after exposure to various stresses, contributing to chronic diseases and cancer, effects largely driven by the senescence‐associated secretory phenotype (SASP). Recent evidence indicates that a subset of senescent cells exhibits immunogenic properties.
Goyer ML +11 more
europepmc +3 more sources
Identification of gingerenone A as a novel senolytic compound.
PLoS ONE, 2022 Senescent cells accumulate with aging and have been shown to contribute to age-associated diseases and organ dysfunction. Eliminating senescent cells with senolytic drugs has been shown to improve age phenotypes in mouse models and there is some initial ...
Ruin Moaddel +7 more
doaj +1 more source
A versatile method for the identification of senolytic compounds
Cell Stress, 2023 The increased burden of senescent cells is as a well-established hallmark of aging and age-related diseases. This finding sparked significant interest in the identification of molecules capable of selectively eliminating senescent cells, so-called ...
Chiara Annunziata +8 more
doaj +1 more source
BMC Biotechnology, 2010 Background Senescent cells are well-recognized in the aging/degenerating human disc. Senescent cells are viable, cannot divide, remain metabolically active and accumulate within the disc over time. Molecular analysis of senescent cells in tissue offers a
Ingram Jane A +4 more
doaj +1 more source
A Senescence Bystander Effect in Human Lung Fibroblasts
Biomedicines, 2021 Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterised by a dense fibrosing of the lung parenchyma. An association between IPF and cellular senescence is well established and several studies now describe a higher abundance of senescent ...
David W. Waters +12 more
doaj +1 more source