Results 11 to 20 of about 12,101,411 (341)
Senescent Cells: A Therapeutic Target in Cardiovascular Diseases
Cells, 2023 Senescent cell accumulation has been observed in age-associated diseases including cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence-associated secretory phenotype (SASP) factors that may cause or worsen many ...
M. Suda +7 more
semanticscholar +2 more sources
Ring-like distribution of constitutive heterochromatin in bovine senescent cells. [PDF]
PLoS ONE, 2011 BACKGROUND: Cells that reach "Hayflick limit" of proliferation, known as senescent cells, possess a particular type of nuclear architecture. Human senescent cells are characterized by the presence of highly condensed senescent associated heterochromatin ...
Andrey Pichugin +3 more
doaj +2 more sources
Targeting senescent cells with NKG2D-CAR T cells
Cell Death DiscoveryThis study investigates the efficacy of NKG2D chimeric antigen receptor (CAR) engineered T cells in targeting and eliminating stress-induced senescent cells in vitro.
Yushuang Deng +9 more
doaj +2 more sources
Flow Cytometry-based Method for Efficient Sorting of Senescent Cells
Bio-Protocol, 2023 Cellular senescence is a reprogrammed cell state triggered as an adaptative response to a variety of stresses, most often those affecting the genome integrity.
Erwan Goy +12 more
doaj +2 more sources
A versatile drug delivery system targeting senescent cells [PDF]
EMBO Molecular Medicine, 2018 Senescent cells accumulate in multiple aging‐associated diseases, and eliminating these cells has recently emerged as a promising therapeutic approach. Here, we take advantage of the high lysosomal β‐galactosidase activity of senescent cells to design a ...
Daniel Muñoz‐Espín +18 more
doaj +2 more sources
Scientific Reports, 2021 A wide range of diseases have been shown to be influenced by the accumulation of senescent cells, from fibrosis to diabetes, cancer, Alzheimer’s and other age-related pathologies.
Marta Poblocka +10 more
doaj +2 more sources
Frontiers in Immunology, 2021 Senescent T cells have been described during aging, chronic infections, and cancer; however, a comprehensive study of the phenotype, function, and transcriptional program of this T cell population in breast cancer (BC) patients is missing.
Maria C. Ramello +28 more
doaj +3 more sources
Senescent cells: an emerging target for diseases of ageing
Nature Reviews Drug Discovery, 2017 Chronological age represents the single greatest risk factor for human disease. One plausible explanation for this correlation is that mechanisms that drive ageing might also promote age-related diseases.
Bennett G Childs +2 more
exaly +2 more sources
Senescent Cells in Cancer Therapy: Friends or Foes? [PDF]
Trends in Cancer, 2020 Several cancer interventions induce DNA damage and promote senescence in cancer and nonmalignant cells. Senescent cells secrete a collection of proinflammatory factors collectively termed the senescence-associated secretory phenotype (SASP). SASP factors
Boshi Wang, J. Kohli, M. Demaria
semanticscholar +2 more sources
Role of Senescent Cells in Cutaneous Wound Healing
Biology, 2022 Simple Summary The biology of cellular senescence has broad implications for the fields of aging, tissue and wound repair, tumor biology, and development.
Allison M Andrade +5 more
semanticscholar +2 more sources