Results 11 to 20 of about 4,484,629 (285)
Senescent human diploid fibroblasts are able to support DNA synthesis and to express markers associated with proliferation [PDF]
, 1990 The characteristic limited reproductive life-span of normal human fibroblasts in culture is due to a steadily decreasing fraction of cells able to proliferate in the standard rich growth media.
Shall, S, Kill, IR
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The effect of radiation on cellular ageing [PDF]
, 2012 This thesis was submitted for the degree of Master of Philosophy and awarded by Brunel UniversityHumans are exposed to low and moderate doses of ionising radiation (IR) from a range of diagnostic and occupational sources which may lead to cellular ...
Sabin, Rebecca Jane
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Targeting cellular senescence in metabolic disease
Molecular Metabolism, 2022 Cellular senescence is a cell fate involving cell cycle arrest, resistance against apoptosis, and the development of a secretome that can be pro-inflammatory.
Allyson K. Palmer +2 more
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Cell Senescence in Lupus [PDF]
Current Rheumatology Reports, 2019 The concept of cellular senescence has been evolving. Although originally proposed based on studies of serum-driven replication of cell lines in vitro, it is now clear that cellular senescence occurs in vivo. It has also become clear that cellular senescence can be triggered by a number of stimuli such as radiation, chemotherapy, activation of ...
Lin, Gao +5 more
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Senescent Cell Depletion Through Targeting BCL-Family Proteins and Mitochondria
Frontiers in Physiology, 2020 Senescent cells with replicative arrest can be generated during genotoxic, oxidative, and oncogenic stress. Long-term retention of senescent cells in the body, which is attributed to highly expressed BCL-family proteins, chronically damages tissues ...
Ying Fan +9 more
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International Journal of Oral Science, 2023 In dentistry, orthodontic root resorption is a long-lasting issue with no effective treatment strategy, and its mechanisms, especially those related to senescent cells, remain largely unknown.
Yue Zhou +9 more
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Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases
Cells, 2020 Senescent cells are generally characterized by permanent cell cycle arrest, metabolic alteration and activation, and apoptotic resistance in multiple organs due to various stressors.
Ping Song, Junqing An, Ming-Hui Zou
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A versatile method for the identification of senolytic compounds
Cell Stress, 2023 The increased burden of senescent cells is as a well-established hallmark of aging and age-related diseases. This finding sparked significant interest in the identification of molecules capable of selectively eliminating senescent cells, so-called ...
Chiara Annunziata +8 more
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Biomarkers to identify and isolate senescent cells. [PDF]
, 2016 Aging is the main risk factor for many degenerative diseases and declining health. Senescent cells are part of the underlying mechanism for time-dependent tissue dysfunction.
Ethan Anders Sarnoski (7215461) +3 more
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Identification of gingerenone A as a novel senolytic compound.
PLoS ONE, 2022 Senescent cells accumulate with aging and have been shown to contribute to age-associated diseases and organ dysfunction. Eliminating senescent cells with senolytic drugs has been shown to improve age phenotypes in mouse models and there is some initial ...
Ruin Moaddel +7 more
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