Results 41 to 50 of about 646 (170)
Biomolecules, 2023 Closely associated with aging and age-related disorders, cellular senescence (CS) is the inability of cells to proliferate due to accumulated unrepaired cellular damage and irreversible cell cycle arrest.
Prashanta Silwal +6 more
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Cellular Senescence in Kidney Fibrosis: Pathologic Significance and Therapeutic Strategies
Frontiers in Pharmacology, 2020 Age-related disorders such as chronic kidney disease (CKD) are increasingly prevalent globally and pose unprecedented challenges. In many aspects, CKD can be viewed as a state of accelerated and premature aging.
Jie Xu +3 more
doaj +1 more source
Astrocytes in Brain Aging and Neurodegeneration: Cellular Mechanisms and Interventional Strategies. [PDF]
J NeurochemAging disrupts astrocyte physiology and contributes to cognitive decline. We highlight recent evidence showing that senescent astrocytes lose lamin‐B1, develop nuclear abnormalities, display impaired mitochondrial and metabolic function, and provide reduced synaptic support.
Gomes FCA, Matias I.
europepmc +2 more sources
Senescence and the SASP: many therapeutic avenues [PDF]
, 2020 Cellular senescence is a stress response that elicits a permanent cell cycle arrest and triggers profound phenotypic changes such as the production of a bioactive secretome, referred to as the senescence-associated secretory phenotype (SASP).
Birch, J, Gil, Jesus
core +1 more source
Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities
Advanced Science, 2020 Aging is a physiological decline in both structural homeostasis and functional integrity, progressively affecting organismal health. A major hallmark of aging is the accumulation of senescent cells, which have entered a state of irreversible cell cycle ...
Shuling Song +4 more
doaj +1 more source
Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration [PDF]
Journal of Neuroinflammation, 2021 AbstractAge-related macular degeneration (AMD), a degenerative disease in the central macula area of the neuroretina and the supporting retinal pigment epithelium, is the most common cause of vision loss in the elderly. Although advances have been made, treatment to prevent the progressive degeneration is lacking.
Keng Siang Lee +4 more
openaire +5 more sources
Reshaping of the tumor microenvironment by cellular senescence: An opportunity for senotherapies
Developmental Cell, 2023 Cellular senescence is a stress response associated with aging and disease, including cancer. Senescent cells undergo a stable cell cycle arrest, undergo a change in morphology and metabolic reprogramming, and produce a bioactive secretome termed the senescence-associated secretory phenotype (SASP).
Gil, J, D’Ambrosio, M
openaire +3 more sources
Cellular Senescence and Senotherapies in the Kidney: Current Evidence and Future Directions [PDF]
Frontiers in Pharmacology, 2020 Cellular senescence refers to a cellular phenotype characterized by an altered transcriptome, pro-inflammatory secretome, and generally irreversible growth arrest. Acutely senescent cells are widely recognized as performing key physiological functions in vivo promoting normal organogenesis, successful wound repair, and cancer defense.
Marie Helena Docherty +7 more
openaire +3 more sources
Long-term cardiovascular complications following sepsis: is senescence the missing link?
Annals of Intensive Care, 2021 Highlights With improved management of patients, sepsis survivors are increasing each year. Early cardiovascular complications, of yet undeciphered mechanisms, are an emerging health issue in post-sepsis syndrome.
Hamid Merdji +3 more
doaj +1 more source
, 2021 Macroautophagy/autophagy is a sophisticated quality control program that limits cellular damage and maintains homeostasis, being an essential part of several lifespan-promoting interventions. However, autophagy is also necessary for full establishment of
Kang, Chanhee +4 more
core +1 more source