Results 41 to 50 of about 767 (193)
Dysfunctional stem and progenitor cells impair fracture healing with age [PDF]
, 2019 Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature; mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies ...
Clauss, Matthias +12 more
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New Trends in Aging Drug Discovery [PDF]
, 2022 Aging is considered the main risk factor for many chronic diseases that frequently appear at advanced ages. However, the inevitability of this process is being questioned by recent research that suggests that senescent cells have specific features that ...
Benhamú Salama, Bellinda +4 more
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Senescence and senotherapies in biliary atresia and biliary cirrhosis
Aging, 2023 Premature senescence occurs in adult hepatobiliary diseases and worsens the prognosis through deleterious liver remodeling and hepatic dysfunction. Senescence might also arises in biliary atresia (BA), the first cause of pediatric liver transplantation. Since alternatives to transplantation are needed, our aim was to investigate premature senescence in
Jannone, Giulia +12 more
openaire +3 more sources
Aging, cellular senescence, and progressive Multiple Sclerosis [PDF]
, 2020 Aging is one of the most important risk factors for the development of several neurodegenerative diseases including progressive multiple sclerosis (MS). Cellular senescence (CS) is a key biological process underlying aging.
Gorgoulis, Vassilis G +4 more
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Biomolecules, 2023 Closely associated with aging and age-related disorders, cellular senescence (CS) is the inability of cells to proliferate due to accumulated unrepaired cellular damage and irreversible cell cycle arrest.
Prashanta Silwal +6 more
doaj +1 more source
Cell fate decision in response to damage:the role of cellular adaptation, senescence and death in tissue homeostasis [PDF]
, 2022 Eukaryotic cells are equipped with adaptive responses that, in response to stress, can activate multiple mechanisms to restore homeostasis. In most cases, the damage is either prevented or reversed and the functional and structural integrity of the cell ...
Nehme, Jamil
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Is "cellular senescence" a misnomer? [PDF]
, 2022 One of the most striking findings in biogerontology in the 2010s was the demonstration that elimination of senescent cells delays many late-life diseases and extends lifespan in mice.
Gems, David, Kern, Carina C
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Cellular Senescence in Kidney Fibrosis: Pathologic Significance and Therapeutic Strategies
Frontiers in Pharmacology, 2020 Age-related disorders such as chronic kidney disease (CKD) are increasingly prevalent globally and pose unprecedented challenges. In many aspects, CKD can be viewed as a state of accelerated and premature aging.
Jie Xu +3 more
doaj +1 more source
: 세포 노화를 조절하는 선택적 오토파지의 네트워크 규명 연구 [PDF]
, 2023 학위논문(박사) -- 서울대학교대학원 : 자연과학대학 생명과학부, 2023. 8. 강찬희.Cellular senescence is a complex stress response implicated in aging. Autophagy can suppress senescence but is counterintuitively necessary for full senescence.
이영현
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Reshaping of the tumor microenvironment by cellular senescence: An opportunity for senotherapies
Developmental Cell, 2023 Cellular senescence is a stress response associated with aging and disease, including cancer. Senescent cells undergo a stable cell cycle arrest, undergo a change in morphology and metabolic reprogramming, and produce a bioactive secretome termed the senescence-associated secretory phenotype (SASP).
Gil, J, D’Ambrosio, M
openaire +4 more sources