Results 41 to 50 of about 276 (129)
Long-term cardiovascular complications following sepsis: is senescence the missing link?
Annals of Intensive Care, 2021 Highlights With improved management of patients, sepsis survivors are increasing each year. Early cardiovascular complications, of yet undeciphered mechanisms, are an emerging health issue in post-sepsis syndrome.
Hamid Merdji +3 more
doaj +1 more source
Senescence and the SASP: many therapeutic avenues [PDF]
, 2020 Cellular senescence is a stress response that elicits a permanent cell cycle arrest and triggers profound phenotypic changes such as the production of a bioactive secretome, referred to as the senescence-associated secretory phenotype (SASP).
Birch, J, Gil, Jesus
core +1 more source
Smooth muscle cell-specific deletion of TXNIP ameliorates medial vascular calcification
Experimental and Molecular MedicineVascular calcification is an important pathological characteristic of cardiovascular diseases, often exacerbated by metabolic disorders such as chronic kidney disease and diabetes mellitus.
Ae-Rang Hwang, Chang-Hoon Woo
doaj +1 more source
Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain
Advanced Science, Volume 13, Issue 46, 17 August 2026.Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh +7 more
wiley +1 more source
Nature CommunicationsThe accumulation of senescent cells in white adipose tissue (WAT) is closely associated with the functional decline of WAT and plays a causal role in the pathogenesis of metabolic diseases.
Eok-Cheon Kim +27 more
doaj +1 more source
Virus-like nanoparticles as a theranostic platform for cancer
Frontiers in Bioengineering and Biotechnology, 2023 Virus-like nanoparticles (VLPs) are natural polymer-based nanomaterials that mimic viral structures through the hierarchical assembly of viral coat proteins, while lacking viral genomes.
Kyeong Rok Kim +5 more
doaj +1 more source
Frontiers in Endocrinology, 2022 Increased insulin resistance and impaired insulin secretion are significant characteristics manifested by patients with type 2 diabetes mellitus (T2DM). The degree and extent of these two features in T2DM vary among races and individuals.
Takaaki Murakami +3 more
doaj +1 more source
iMeta, Volume 5, Issue 4, August 2026.Microbiome age (MA) has emerged as an innovative biomarker of biological aging, reflecting host aging trajectories through dynamic alterations in microbial composition, function, and host–microbe interactions across multiple body ecosystems. Diverse computational strategies—including traditional machine learning, deep learning, and multi‐omics ...
Zhexin Ni +26 more
wiley +1 more source
Epilepsia, Volume 67, Issue 7, Page 3779-3790, July 2026.Abstract Objective Current pharmacotherapy for temporal lobe epilepsy (TLE) is limited to symptomatic treatment and leaves approximately one third of patients with inadequate seizure control. Discovering disease‐modifying targets is an unmet clinical need. We have previously identified senescent cells (SCs) as one such target. Many drugs that eliminate
David J. McFall +3 more
wiley +1 more source
Molecular Reproduction and Development, Volume 93, Issue 5, May 2026.ABSTRACT Ovarian aging is characterized by the reduction of the follicular pool and a progressive loss in oocyte quality. Although these changes have initially been attributed to oocyte alterations, increasing evidence indicates that stromal deterioration plays a central role in this process.
Stefhani Martins Barcelos +3 more
wiley +1 more source