The Role of Metallodrugs in Cellular Senescence [PDF]
, 2023 Delivering alternative strategies to deal with cancer is a huge milestone in research. Cancer cells can give a senescence response as consequence of cellular stress or external stimuli such as the use of chemotherapies, which could end up eventually in ...
Fernández-Moreira, Vanesa +1 more
core +1 more source
Repairing damaged lungs using regenerative therapy [PDF]
, 2021 There is an urgent need for better treatment of lung diseases that are a major cause of morbidity and mortality worldwide. This urgency is illustrated by the current COVID-19 health crisis.
Gosens, Reinoud +3 more
core +4 more sources
The role of cellular senescence in female reproductive aging and the potential for senotherapeutic interventions [PDF]
, 2021 BACKGROUND: Advanced maternal age is associated with decreased oocyte quantity and quality as well as uterine and placental dysfunctions. These changes lead to infertility, pregnancy complications and birth defects in the offspring.
Borghesan, Michela +3 more
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Senotherapeutic Effect of Retinaldehyde and Hyaluronate Fragments in Dermatoporosis
Dermatopathology, 2023 Cellular senescence is one of the important mechanisms of skin aging. In a recent study, we have shown that in patients with dermatoporosis, an extreme senescence condition of the skin, cells positive for p16Ink4a, a biomarker of senescence, were ...
Aysin Kaya +2 more
doaj +1 more source
Eliminating senescent cells by white adipose tissue–targeted senotherapy alleviates age-related hepatic steatosis through decreasing lipolysis [PDF]
GeroScienceLi Liao
exaly +2 more sources
Senescence plays a role in myotonic dystrophy type 1 br [PDF]
, 2022 Myotonic dystrophy type 1 (DM1; MIM #160900) is an autosomal dominant disorder, clinically characterized by progressive muscular weakness and multisystem degeneration.
Araúzo Bravo, Marcos J. +12 more
core +1 more source
A stress-induced cilium-to-PML-NB route drives senescence initiation
Nature Communications, 2023 Exposure to irreparable stresses induces transient ciliogenesis, enabling communication with PML-NBs via a FBF1 pathway to trigger senescence in mammalian cells.
Xiaoyu Ma +14 more
doaj +1 more source
Hallmarks and Biomarkers of Skin Senescence: An Updated Review of Skin Senotherapeutics
Antioxidants, 2023 Aging is a complex process characterized by an ongoing decline in physiological functions, leading to degenerative diseases and an increased probability of death. Cellular senescence has been typically considered as an anti-proliferative process; however,
Darya Bulbiankova +5 more
doaj +1 more source
The interaction between cellular senescence and chronic kidney disease as a therapeutic opportunity
Frontiers in Pharmacology, 2022 Chronic kidney disease (CKD) is an increasingly serious public health problem in the world, but the effective therapeutic approach is quite limited at present.
Jing-Li Zhao +4 more
doaj +1 more source
Assessment of Pullulan, a Microbial Polysaccharide, as a Matrix for Senotherapeutics Delivery
Chemistry Proceedings, 2023 This study’s objective was to assess pullulan, in the form of pullulan acetate, as a matrix for senotherapeutics delivery. Polymeric nanoparticles loaded with various senotherapeutics (metformin, quercitin, kaempferol, curcumin, and luteolin) were ...
Ramona-Daniela Pavaloiu +4 more
doaj +1 more source