Results 21 to 30 of about 276 (129)

Senotherapy for attenuation of cellular senescence in aging and organ implantation

Journal of Industrial and Engineering Chemistry, 2018
Abstract Cellular senescence in transplant is induced by aging and therapy-induced stress, which is caused by generation of senescent cells in transplant during engraftment. These senescent cells induce transplant failure due to secretion of senescence-associated secretory phenotype (SASP).
Dong Hoon Kang, Yeon Soo Park, Dong Yun Lee   +2 more
core   +3 more sources

Inhibition of miMOMP-induced SASP to combat age-related disease [PDF]

Frontiers in Aging
Cellular senescence, first described in 1961, was initially observed in normal human fibroblasts that ceased proliferating after a finite number of divisions in culture.
Xiaoli Liao, Zhennan Guo, Zhennan Guo, Mouhai He, Yichun Zhang   +4 more
doaj   +2 more sources

Impact and potential value of immunosenescence on solid gastrointestinal tumors [PDF]

Frontiers in Immunology
Solid gastrointestinal tumors often respond poorly to immunotherapy for the complex tumor microenvironment (TME), which is exacerbated by immune system alterations. Immunosenescence is the process of increased diversification of immune genes due to aging
Tianshuai Zhang, Rongbo Wen, Hao Fan, Yue Yu, Hang Jia, Zhiying Peng, Leqi Zhou, Guanyu Yu, Wei Zhang   +8 more
doaj   +2 more sources

Connecting epigenetics and inflammation in vascular senescence: state of the art, biomarkers and senotherapeutics [PDF]

Frontiers in Genetics
Vascular diseases pose major health challenges, and understanding their underlying molecular mechanisms is essential to advance therapeutic interventions. Cellular senescence, a hallmark of aging, is a cellular state characterized by cell-cycle arrest, a
Oscar Fraile-Martinez, Oscar Fraile-Martinez, Diego De Leon-Oliva, Diego De Leon-Oliva, Diego Liviu Boaru, Diego Liviu Boaru, Patricia De Castro-Martinez, Patricia De Castro-Martinez, Cielo Garcia-Montero, Cielo Garcia-Montero, Silvestra Barrena-Blázquez, Silvestra Barrena-Blázquez, Joaquin García-García, Natalio García-Honduvilla, Natalio García-Honduvilla, Melchor Alvarez-Mon, Melchor Alvarez-Mon, Melchor Alvarez-Mon, Melchor Alvarez-Mon, Laura Lopez-Gonzalez, Laura Lopez-Gonzalez, Raul Diaz-Pedrero, Raul Diaz-Pedrero, Raul Diaz-Pedrero, Luis G. Guijarro, Luis G. Guijarro, Luis G. Guijarro, Luis G. Guijarro, Miguel A. Ortega, Miguel A. Ortega, Miguel A. Ortega, Miguel A. Ortega   +31 more
doaj   +2 more sources

A biomimetic senotherapy replenishing MAT2A promotes wound regeneration in preclinical models

Nature Communications
Timely infiltration and effective turnover of macrophages after trauma are essential for wound regeneration. In pathological conditions, such as diabetic wounds, how disturbances in cellular collaboration leads to persistent inflammatory infiltration ...
Dongming LV, Lei Ren, Zirui Zhao, Yanchao Rong, Miao Chen, Hao Yang, Rong Yin, Ruixi Zeng, Hua Chao, Xiaohui Li, Zhongye Xu, Zhicheng Hu, Xiaoling Cao, Wuguo Deng, Qing Tang, Bing Tang   +15 more
doaj   +3 more sources

Senescence and Cancer: A Review of Clinical Implications of Senescence and Senotherapies [PDF]

Cancers, 2020
Cellular senescence is a key component of human aging that can be induced by a range of stimuli, including DNA damage, cellular stress, telomere shortening, and the activation of oncogenes. Senescence is generally regarded as a tumour suppressive process, both by preventing cancer cell proliferation and suppressing malignant progression from pre ...
Wyld, L., Bellantuono, I., Tchkonia, T., Morgan, J., Turner, O., Foss, F., George, J., Danson, S., Kirkland, J.L.   +8 more
openaire   +4 more sources

Senotherapeutics in Cancer and HIV

Cells, 2022
Cellular senescence is a stress-response mechanism that contributes to homeostasis maintenance, playing a beneficial role during embryogenesis and in normal adult organisms.
Laura Sánchez-Díaz, Asunción Espinosa-Sánchez, José-Ramón Blanco, Amancio Carnero   +3 more
doaj   +1 more source

Senescence and senotherapies in biliary atresia and biliary cirrhosis

Aging, 2023
Premature senescence occurs in adult hepatobiliary diseases and worsens the prognosis through deleterious liver remodeling and hepatic dysfunction. Senescence might also arises in biliary atresia (BA), the first cause of pediatric liver transplantation. Since alternatives to transplantation are needed, our aim was to investigate premature senescence in
Jannone, Giulia, Bonaccorsi Riani, Eliano, de Magnée, Catherine, Tambucci, Roberto, Evraerts, Jonathan, Ravau, Joachim, Baldin, Pamela, Bouzin, Caroline, Loriot, Axelle, Gatto, Laurent, Decottignies, Anabelle, Najimi, Mustapha, Sokal, Etienne Marc   +12 more
openaire   +2 more sources

Cellular Senescence: Mechanisms and Therapeutic Potential

Biomedicines, 2021
Cellular senescence is a complex and multistep biological process which cells can undergo in response to different stresses. Referring to a highly stable cell cycle arrest, cellular senescence can influence a multitude of biological processes—both ...
Zehuan Liao, Han Lin Yeo, Siaw Wen Wong, Yan Zhao   +3 more
doaj   +1 more source

Cellular senescence: a double-edged sword in cancer therapy

Frontiers in Oncology, 2023
Over the past few decades, cellular senescence has been identified in cancer patients undergoing chemotherapy and radiotherapy. Senescent cells are generally characterized by permanent cell cycle arrest as a response to endogenous and exogenous stresses.
Shuai Xiao, Dongmin Qin, Xueyang Hou, Lingli Tian, Yeping Yu, Rui Zhang, Rui Zhang, Hao Lyu, Dong Guo, Xing-Zhen Chen, Cefan Zhou, Jingfeng Tang   +11 more
doaj   +1 more source