Results 21 to 30 of about 646 (170)
Treating Senescence like Cancer: Novel Perspectives in Senotherapy of Chronic Diseases [PDF]
International Journal of Molecular Sciences, 2020 The WHO estimated around 41 million deaths worldwide each year for age-related non-communicable chronic diseases. Hence, developing strategies to control the accumulation of cell senescence in living organisms and the overall aging process is an urgently needed problem of social relevance.
Alessia Mongelli +6 more
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Pleiotropic effects of BAFF on the senescence-associated secretome and growth arrest [PDF]
eLife, 2023 Senescent cells release a variety of cytokines, proteases, and growth factors collectively known as the senescence-associated secretory phenotype (SASP). Sustained SASP contributes to a pattern of chronic inflammation associated with aging and implicated
Martina Rossi +17 more
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Integrative Approaches to Treating Cellular Senescence in Kidney Disease
Advanced ScienceCellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in ...
Tomoka Misawa +3 more
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Cell Death and Disease, 2022 Aging inducing the development of senescent cells (SNCs) in various tissues is considered as the main cause of the age-related diseases. Senotherapy has become a promising anti-aging therapy.
Zongke Bai +7 more
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Translational Medicine of Aging, 2023 Chronic aging represents the leading risk factor for the vast majority of age-related diseases, which together contribute to increased morbidities and elevated mortalities in late life.
Yu Sun
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Connecting epigenetics and inflammation in vascular senescence: state of the art, biomarkers and senotherapeutics [PDF]
Frontiers in GeneticsVascular diseases pose major health challenges, and understanding their underlying molecular mechanisms is essential to advance therapeutic interventions. Cellular senescence, a hallmark of aging, is a cellular state characterized by cell-cycle arrest, a
Oscar Fraile-Martinez +31 more
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Senotherapeutic Effect of Retinaldehyde and Hyaluronate Fragments in Dermatoporosis
Dermatopathology, 2023 Cellular senescence is one of the important mechanisms of skin aging. In a recent study, we have shown that in patients with dermatoporosis, an extreme senescence condition of the skin, cells positive for p16Ink4a, a biomarker of senescence, were ...
Aysin Kaya +2 more
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The interaction between cellular senescence and chronic kidney disease as a therapeutic opportunity
Frontiers in Pharmacology, 2022 Chronic kidney disease (CKD) is an increasingly serious public health problem in the world, but the effective therapeutic approach is quite limited at present.
Jing-Li Zhao +4 more
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Frontiers in Endocrinology, 2023 Recent advances in aging research have provided novel insights for the development of senotherapy, which utilizes cellular senescence as a therapeutic target.
Sachi Matsubayashi +3 more
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Adoptive NK cell therapy: a potential revolutionary approach in longevity therapeutics
Immunity & AgeingThe aging process intricately involves immune system dynamics, with a crucial role in managing senescent cells (SNCs) and their senescence-associated secretory phenotypes (SASPs).
Xuewen Deng, Hiroshi Terunuma
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