Results 61 to 70 of about 767 (193)
Mitochondria, telomeres and cell senescence: Implications for lung ageing and disease
, 2017 Cellular senescence, the irreversible loss of replicative capacity in somatic cells, plays a causal role in the development of age-related pathology and in a number of age-related chronic inflammatory diseases.
Barnes, PJ, Birch, J, Passos, JF
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Virus-like nanoparticles as a theranostic platform for cancer
Frontiers in Bioengineering and Biotechnology, 2023 Virus-like nanoparticles (VLPs) are natural polymer-based nanomaterials that mimic viral structures through the hierarchical assembly of viral coat proteins, while lacking viral genomes.
Kyeong Rok Kim +5 more
doaj +1 more source
Senescence under appraisal: hopes and challenges revisited. [PDF]
, 2021 In recent years, cellular senescence has become the focus of attention in multiple areas of biomedical research. Typically defined as an irreversible cell cycle arrest accompanied by increased cellular growth, metabolic activity and by a characteristic ...
Davan-Wetton, CSA +3 more
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Frontiers in Endocrinology, 2022 Increased insulin resistance and impaired insulin secretion are significant characteristics manifested by patients with type 2 diabetes mellitus (T2DM). The degree and extent of these two features in T2DM vary among races and individuals.
Takaaki Murakami +3 more
doaj +1 more source
Diverse Roles of Cellular Senescence in Skeletal Muscle Inflammation, Regeneration, and Therapeutics
Frontiers in Pharmacology, 2021 Skeletal muscle undergoes vigorous tissue remodeling after injury. However, aging, chronic inflammatory diseases, sarcopenia, and neuromuscular disorders cause muscle loss and degeneration, resulting in muscular dysfunction.
Yuki Saito +2 more
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A Senescent Cluster in Aged Human Hematopoietic Stem Cell Compartment as Target for Senotherapy. [PDF]
Int J Mol SciTo identify the differences between aged and young human hematopoiesis, we performed a direct comparison of aged and young human hematopoietic stem and progenitor cells (HSPCs). Alterations in transcriptome profiles upon aging between humans and mice were then compared.
Poisa-Beiro L +12 more
europepmc +3 more sources
Senescence and the SASP: many therapeutic avenues [PDF]
, 2020 Cellular senescence is a stress response that elicits a permanent cell cycle arrest and triggers profound phenotypic changes such as the production of a bioactive secretome, referred to as the senescence-associated secretory phenotype (SASP).
Birch, J, Gil, J
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Periodontology 2000, EarlyView.Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng +4 more
wiley +1 more source
Immunotherapy-based targeting of senescent cells [PDF]
Cellular senescence is a state of permanent cell cycle arrest, characterized by substantial macromolecular alterations and senescence-associated secretory phenotype (SASP) in response to various stressors.
Deng, Yushuang
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Smooth muscle cell-specific deletion of TXNIP ameliorates medial vascular calcification
Experimental and Molecular MedicineVascular calcification is an important pathological characteristic of cardiovascular diseases, often exacerbated by metabolic disorders such as chronic kidney disease and diabetes mellitus.
Ae-Rang Hwang, Chang-Hoon Woo
doaj +1 more source