Results 61 to 70 of about 276 (129)

Breaking barriers in pulmonary health of patients with metabolic diseases: senolytics and beyond

Frontiers in Aging
Aging is the primary risk factor for most chronic diseases and is accompanied by the progressive accumulation of senescent cells within tissues. While cellular senescence initially serves as a protective mechanism that limits the proliferation of damaged
Michaela Rennerova, Michaela Rennerova, Marie Zaloudikova, Martin Haluzik, Martin Haluzik, Sona Stemberkova Hubackova, Sona Stemberkova Hubackova   +6 more
doaj   +1 more source

Potential Clinical Implications of Senotherapies for Cardiovascular Disease

Circulation Journal
Aging is a major risk factor for cardiovascular diseases (CVDs) and accumulating evidence indicates that biological aging has a significant effect on the onset and progression of CVDs. In recent years, therapies targeting senescent cells (senotherapies), particularly senolytics that selectively eliminate senescent cells, have been developed and show ...
Suda, Masayoshi, Katsuumi, Goro, Tchkonia, Tamar, Kirkland, James L., Minamino, Tohru   +4 more
openaire   +2 more sources

Mitochondrial Respiratory Supercomplex Assembly Factor COX7RP Contributes to Lifespan Extension in Mice

Aging Cell, Volume 25, Issue 1, January 2026.
Mitochondrial respiratory supercomplex assembly factor COX7RP improves metabolic homeostasis and contributes to lifespan extension in mice. The overexpression of COX7RP reduces white adipose tissue mass and downregulates senescence‐associated secreted phenotype‐related genes in the tissue, suggesting that COX7RP plays a role in preventing aging through
Kazuhiro Ikeda, Sachiko Shiba, Masataka Yokoyama, Masanori Fujimoto, Kuniko Horie, Tomoaki Tanaka, Satoshi Inoue   +6 more
wiley   +1 more source

Senescent cells: a therapeutic target for cardiovascular disease [PDF]

, 2018
Cellular senescence, a major tumor-suppressive cell fate, has emerged from humble beginnings as an in vitro phenomenon into recognition as a fundamental mechanism of aging.
Childs, B.G., Deursen, J.M.A. van, Jan M. van Deursen, Bennett G. Childs, Li, H., Hu Li   +5 more
core   +2 more sources

Inducible skeletal muscle-specific p53 deletion alleviates high-fat diet-induced insulin resistance by modulating mitochondria-associated membrane in obese mice

Redox Biology
p53 has been implicated in metabolic regulation, but its role in obesity-induced skeletal muscle insulin resistance remains incompletely understood. This study aimed to determine the functional contribution of skeletal muscle p53 to insulin resistance ...
Soyoung Park, Jin Ki Jung, Jung-Yoon Heo, Themis Thoudam, Su-Yeon Jeong, Seok-Hui Kang, Chang-Hoon Woo, Hyoung Chul Choi, In-kyu Lee, Jinmyoung Dan, Jongsoon Lee, Jae-Ryong Kim, So-Young Park   +12 more
doaj   +1 more source

From Neuron‐Centric to Glia‐Centric: How Aging Glial Networks Drive Neurodegenerative Disease

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
During aging, progressive alterations in glial networks reshape intercellular communication within the central nervous system. In the young brain, astrocytes and microglia actively regulate metabolic, immune, and synaptic processes that sustain neural circuit stability.
Lívia de Sá Hayashide, Bruna Pessoa, Gustavo Dias, Bruno Pontes, Rafael Serafim Pinto, Luan Pereira Diniz   +5 more
wiley   +1 more source

Therapeutic Implication of Anti‐CTGF in Neointimal Hyperplasia via Regulating Mitochondrial Dysfunction and VSMC Phenotypic Switch

Cardiovascular Therapeutics, Volume 2026, Issue 1, 2026.
Connective tissue growth factor (CTGF), also known as CCN2, is a matricellular protein of the CCN family (CCN1‐6) that regulates the proliferation of vascular smooth muscle cells (VSMCs), thereby contributing to the pathogenesis of atherosclerosis and hypertension.
Ae-Rang Hwang, Chang-Hoon Woo, Young Jin Kang, Irfan Ahmad   +3 more
wiley   +1 more source

Immunosenescence: Molecular Mechanisms, Diseases, and Therapeutic Innovations

MedComm, Volume 6, Issue 12, December 2025.
Along with organismal aging or pathogenic processes especially tumor, multiple immune cell types exhibit those well‐established hallmarks of cellular senescent phenotype, mainly characterized by irreversible cell cycle arrest, metabolic disorder, and over production of SASP.
Ninghan Gong, Xiting Pan, Yusi Deng, Jiajia Che, Junhao Bao, Mengqi Wang, Chuan Xu, Xiaowei Liu, Ying Shi   +8 more
wiley   +1 more source

Heterogeneity of Cellular Senescence: Subtype‐Specific Mechanisms and the Emerging Role of Plasma Membrane Damage

Cancer Science, Volume 116, Issue 12, Page 3274-3285, December 2025.
Just as the term “cancer cell” encompasses a wide spectrum of cells, the term “senescent cell” should also be regarded as an umbrella term that includes cells with heterogeneous molecular profiles. In this review, we provide an updated overview of the molecular mechanisms underlying distinct senescent cell subtypes induced by various stimuli, including
Enaam Alghamdi, Keiko Kono
wiley   +1 more source

Telomere stabilization by metformin mitigates the progression of atherosclerosis via the AMPK-dependent p-PGC-1α pathway

Experimental and Molecular Medicine
Telomere dysfunction is a well-known molecular trigger of senescence and has been associated with various age-related diseases, including atherosclerosis.
Jin Young Sung, Seul Gi Kim, So-Young Park, Jae-Ryong Kim, Hyoung Chul Choi   +4 more
doaj   +1 more source