Results 61 to 70 of about 646 (170)

Homoharringtonine exhibits senotherapeutic activity that mitigates diet- and age-associated obesity and insulin resistance and extends lifespan in mice

Nature Communications
The accumulation of senescent cells in white adipose tissue (WAT) is closely associated with the functional decline of WAT and plays a causal role in the pathogenesis of metabolic diseases.
Eok-Cheon Kim, Han-Byul Jung, Yu-kyoung Park, Youlim Son, Hye-Na Cha, Yash Patel, Ju Hee Lee, Minah Choi, Soyoung Park, Il-Kug Kim, Lauren Pickel, Seungju Lee, Yuna Ha, Min-Gyeong Shin, Qiwei Zhang, Jielin Yang, Bruno Rodrigues de Oliveira, Nathaniel Vo, Annie Yew, Jacques Togo, Kafi N. Ealey, Su-Ryun Jung, Sunjin Moon, Hye-Jin Yoon, Jee-Young Lee, Hoon-Ki Sung, Jae-Ryong Kim, So-Young Park   +27 more
doaj   +1 more source

From senescence and inflammaging to systemic comorbidities: Drivers of aging‐associated periodontitis

Periodontology 2000, EarlyView.
Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng, Chew Tin Zar Aung, Samuel F. Suslavich, Sinem Esra Sahingur, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice

Nature Communications, 2020
Senotherapy, the removal of aged T cells, is an effective approach to attenuate age-related diseases. Here the authors report a CD153 targeting vaccine that prevents the accumulation of senescent adipose tissue T cells in mice on high-fat diet, which is ...
Shota Yoshida, Hironori Nakagami, Hiroki Hayashi, Yuka Ikeda, Jiao Sun, Akiko Tenma, Hideki Tomioka, Tomohiro Kawano, Munehisa Shimamura, Ryuichi Morishita, Hiromi Rakugi   +10 more
doaj   +1 more source

From Mesenchymal Stromal Cells to Extracellular Vesicles: Scalable Strategies for Ovarian Stroma Regeneration

Molecular Reproduction and Development, Volume 93, Issue 5, May 2026.
ABSTRACT Ovarian aging is characterized by the reduction of the follicular pool and a progressive loss in oocyte quality. Although these changes have initially been attributed to oocyte alterations, increasing evidence indicates that stromal deterioration plays a central role in this process.
Stefhani Martins Barcelos, Amandda Évelin Silva‐Carvalho, Felipe Perecin, Juliana Lott Carvalho   +3 more
wiley   +1 more source

Modulation of tumor plasticity by senescent cells: Deciphering basic mechanisms and survival pathways to unravel therapeutic options [PDF]

Genetics and Molecular Biology
Senescence is a cellular state in which the cell loses its proliferative capacity, often irreversibly. Physiologically, it occurs due to a limited capacity of cell division associated with telomere shortening, the so-called replicative senescence. It can
Andrew Oliveira Silva, Thais Cardoso Bitencourt, Jose Eduardo Vargas, Lucas Rosa Fraga, Eduardo Filippi-Chiela   +4 more
doaj   +1 more source

Morphofunctional Heterogeneity and Plasticity of Glioblastoma Cells Induced to Senescence by Temozolomide

Aging Cell, Volume 25, Issue 4, April 2026.
Glioblastoma cells induced to senescence by Temozolomide are heterogeneous, with the emergence of two main states, named E‐state and F‐state, which differ in cellular morphometry, survival mechanisms, and sensitivity to autophagy modulators and senolytics. These states are dynamic, with the occurrence of morphofunctional transitions.
Solon Andrades da Rosa, Henrique Quaiato de Oliveira, Laura Boose de Mendonça, Nicole Borgmann de Oliveira, Mariane da Cunha Jaeger, Luiza Cherobini Pereira, Fernanda Dittrich Pinto Oliveira, Debora Santos‐Sousa, Fernanda Saez‐Calazans, Luana Lenz, Melike Lakadamyali, Guido Lenz, Eduardo Cremonese Filippi‐Chiela   +12 more
wiley   +1 more source

Senoterapia: una nueva perspectiva para el tratamiento de enfermedades neurodegenerativas [PDF]

, 2021
La senoterapia abarca todas aquellas estrategias terapéuticas dirigidas contra las células senescentes y/o el fenotipo secretor. La senescencia celular es un estado que se caracteriza por la detención permanente del ciclo celular, resistencia a la ...

core  

Sex-Specific Protection of Endothelial Function after Vascular Ischemia/Reperfusion Injury by the Senomorphic Agent Ruxolitinib

, 2023
Ischemia/reperfusion (I/R)-induced endothelial dysfunction occurs in various cardiovascular disorders. I/R injury is partially driven by the release of cytokines.
Sabine Pohl, Lars Saemann, Lotta Hartrumpf, Gábor Szabó, Paula Naujoks, Andreas Simm   +5 more
core   +1 more source

Self‐Immolative Systems in Diagnostic and Therapeutic Applications

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
Self‐Immolative Systems enable the precise, residue‐free release of active molecules, drugs, probes, or sensors, via cyclization or elimination, triggered by specific stimuli. Their versatility drives advances in drug delivery, diagnostics, nanotechnology, materials chemistry, and biosensing, offering chemists control over molecular activation and ...
Windbedema Prisca Ouédraogo, Thomas Cailly, Valérie Collot   +2 more
wiley   +1 more source

Novel Role of Mammalian Cell Senescence-Sustenance of Muscle Larvae of Trichinella spp

, 2022
Muscle larva of the parasitic nematode Trichinella spp. lives in a portion of muscle fibre transformed to a nurse cell (NC). Based on our previous transcriptomic studies, NC growth arrest was inferred to be accompanied by cellular senescence.
Całka-Kresa, Małgorzata, Dabrowska, Magdalena, Kępczyńska, Agnieszka, Doligalska, Maria, Sikora, Ewa, Goździk, Katarzyna, Skoneczny, Marek, Zieliński, Zbigniew   +7 more
core   +1 more source