Results 71 to 80 of about 767 (193)
A window for reversibility in pulmonary arterial hypertension [PDF]
, 2021 Pulmonary arterial hypertension (PAH) is a rare, chronic lung disease. In patients with PAH, arteries in the lung progressively occlude and cause high pulmonary blood pressure.
van der Feen, Diederik
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Nature Communications, 2020 Senotherapy, the removal of aged T cells, is an effective approach to attenuate age-related diseases. Here the authors report a CD153 targeting vaccine that prevents the accumulation of senescent adipose tissue T cells in mice on high-fat diet, which is ...
Shota Yoshida +10 more
doaj +1 more source
Hypoxia-Inducible Factor-1α: The Master Regulator of Endothelial Cell Senescence in Vascular Aging [PDF]
, 2020 Aging is one of the hottest topics in biomedical research. Advances in research and medicine have helped to preserve human health, leading to an extension of life expectancy.
Alique, Matilde +5 more
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Aging Cell, Volume 25, Issue 4, April 2026.Glioblastoma cells induced to senescence by Temozolomide are heterogeneous, with the emergence of two main states, named E‐state and F‐state, which differ in cellular morphometry, survival mechanisms, and sensitivity to autophagy modulators and senolytics. These states are dynamic, with the occurrence of morphofunctional transitions.
Solon Andrades da Rosa +12 more
wiley +1 more source
Oxidative Medicine and Cellular Longevity, 2022 Ovarian damage induced by platinum‐based chemotherapy seriously affects young women with cancer, manifesting as infertility, early menopause, and premature ovarian insufficiency. However, effective prevention strategies for such damage are lacking. Senescent cells may be induced by chemotherapeutic agents.
Dingfu Du +11 more
openaire +2 more sources
Self‐Immolative Systems in Diagnostic and Therapeutic Applications
ChemMedChem, Volume 21, Issue 5, 13 March 2026.Self‐Immolative Systems enable the precise, residue‐free release of active molecules, drugs, probes, or sensors, via cyclization or elimination, triggered by specific stimuli. Their versatility drives advances in drug delivery, diagnostics, nanotechnology, materials chemistry, and biosensing, offering chemists control over molecular activation and ...
Windbedema Prisca Ouédraogo +2 more
wiley +1 more source
Modulation of tumor plasticity by senescent cells: Deciphering basic mechanisms and survival pathways to unravel therapeutic options [PDF]
Genetics and Molecular BiologySenescence is a cellular state in which the cell loses its proliferative capacity, often irreversibly. Physiologically, it occurs due to a limited capacity of cell division associated with telomere shortening, the so-called replicative senescence. It can
Andrew Oliveira Silva +4 more
doaj +1 more source
The hyperfunction theory: An emerging paradigm for the biology of aging [PDF]
, 2022 The process of senescence (aging) is predominantly determined by the action of wild-type genes. For most organisms, this does not reflect any adaptive function that senescence serves, but rather evolutionary effects of declining selection against genes ...
Gems, D
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Pleiotropic effects of BAFF on the senescence-associated secretome and growth arrest
eLife, 2023 Senescent cells release a variety of cytokines, proteases, and growth factors collectively known as the senescence-associated secretory phenotype (SASP). Sustained SASP contributes to a pattern of chronic inflammation associated with aging and implicated
Martina Rossi +17 more
doaj +1 more source
Senoterapia: una nueva perspectiva para el tratamiento de enfermedades neurodegenerativas [PDF]
, 2021 La senoterapia abarca todas aquellas estrategias terapéuticas dirigidas contra las células senescentes y/o el fenotipo secretor. La senescencia celular es un estado que se caracteriza por la detención permanente del ciclo celular, resistencia a la ...
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