Results 71 to 80 of about 646 (170)

Targeting Senescence as a Therapeutic Opportunity for Triple-Negative Breast Cancer.

, 2023
Triple-negative breast cancer (TNBC) is associated with an elevated risk of recurrence and poor prognosis. Historically, only chemotherapy was available as systemic treatment, but immunotherapy and targeted therapies currently offer prolonged benefits ...

core   +1 more source

Potential Clinical Implications of Senotherapies for Cardiovascular Disease

Circulation Journal
Aging is a major risk factor for cardiovascular diseases (CVDs) and accumulating evidence indicates that biological aging has a significant effect on the onset and progression of CVDs. In recent years, therapies targeting senescent cells (senotherapies), particularly senolytics that selectively eliminate senescent cells, have been developed and show ...
Suda, Masayoshi, Katsuumi, Goro, Tchkonia, Tamar, Kirkland, James L., Minamino, Tohru   +4 more
openaire   +2 more sources

Mitochondrial Respiratory Supercomplex Assembly Factor COX7RP Contributes to Lifespan Extension in Mice

Aging Cell, Volume 25, Issue 1, January 2026.
Mitochondrial respiratory supercomplex assembly factor COX7RP improves metabolic homeostasis and contributes to lifespan extension in mice. The overexpression of COX7RP reduces white adipose tissue mass and downregulates senescence‐associated secreted phenotype‐related genes in the tissue, suggesting that COX7RP plays a role in preventing aging through
Kazuhiro Ikeda, Sachiko Shiba, Masataka Yokoyama, Masanori Fujimoto, Kuniko Horie, Tomoaki Tanaka, Satoshi Inoue   +6 more
wiley   +1 more source

From Neuron‐Centric to Glia‐Centric: How Aging Glial Networks Drive Neurodegenerative Disease

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
During aging, progressive alterations in glial networks reshape intercellular communication within the central nervous system. In the young brain, astrocytes and microglia actively regulate metabolic, immune, and synaptic processes that sustain neural circuit stability.
Lívia de Sá Hayashide, Bruna Pessoa, Gustavo Dias, Bruno Pontes, Rafael Serafim Pinto, Luan Pereira Diniz   +5 more
wiley   +1 more source

Immunosenescence: Molecular Mechanisms, Diseases, and Therapeutic Innovations

MedComm, Volume 6, Issue 12, December 2025.
Along with organismal aging or pathogenic processes especially tumor, multiple immune cell types exhibit those well‐established hallmarks of cellular senescent phenotype, mainly characterized by irreversible cell cycle arrest, metabolic disorder, and over production of SASP.
Ninghan Gong, Xiting Pan, Yusi Deng, Jiajia Che, Junhao Bao, Mengqi Wang, Chuan Xu, Xiaowei Liu, Ying Shi   +8 more
wiley   +1 more source

Heterogeneity of Cellular Senescence: Subtype‐Specific Mechanisms and the Emerging Role of Plasma Membrane Damage

Cancer Science, Volume 116, Issue 12, Page 3274-3285, December 2025.
Just as the term “cancer cell” encompasses a wide spectrum of cells, the term “senescent cell” should also be regarded as an umbrella term that includes cells with heterogeneous molecular profiles. In this review, we provide an updated overview of the molecular mechanisms underlying distinct senescent cell subtypes induced by various stimuli, including
Enaam Alghamdi, Keiko Kono
wiley   +1 more source

Ignoring the planet: A critical blind spot for research on ageing

Journal of Internal Medicine, Volume 298, Issue 6, Page 578-590, December 2025.
Abstract Although research on ageing has largely concentrated on understanding the fundamental biology of the ageing process and devising pharmaceutical interventions in order to slow it down, increasing evidence has underscored the crucial role of environmental inputs across the life course and across generations, in shaping both individual and ...
Paul Shiels, Ognian Neytchev, Gillian Borland, Polina Germushkina, Richard Johnson, Peter Stenvinkel, Tina Woods   +6 more
wiley   +1 more source

Cellular Senescence and Immunosenescence in Melanoma: Insights From the Tumor Microenvironment

Cancer Medicine, Volume 14, Issue 17, September 2025.
ABSTRACT Background Melanoma is one of the most immunogenic malignancies, yet resistance to immune checkpoint inhibitors (ICIs) remains a major obstacle to durable therapeutic success. Emerging evidence indicates that aging‐related processes, including cellular senescence and immunosenescence, can reshape the tumor microenvironment (TME) to favor ...
Lihua Xiong, Jian Cheng
wiley   +1 more source

Cellular Senescence in Cancer: Mechanisms, Roles in Tumor Progression, and Therapeutic Implications

MedComm – Oncology, Volume 4, Issue 3, September 2025.
Senescent tumor cells in TME exhibit dual roles. “Angels” secrete SASPs/DAMPs to boost immunological clearance and antitumor immunity via MHC‐I upregulation; “Demons” produce tumor‐promoting SASPs recruiting MDSCs to drive malignancy. ABSTRACT Cellular senescence, a state of irreversible cell cycle arrest accompanied by a senescence‐associated ...
Jingrui Yan, Yu Zhang, Guohua Mao, Jun Yu, Tianxing Zhou, Jihui Hao   +5 more
wiley   +1 more source

Senescence of Tumor Cells in Anticancer Therapy—Beneficial and Detrimental Effects

, 2022
Cellular senescence process results in stable cell cycle arrest, which prevents cell proliferation. It can be induced by a variety of stimuli including metabolic stress, DNA damage, telomeres shortening, and oncogenes activation.
Wiktoria Monika Piskorz, Marzanna Cechowska-Pasko, Cechowska-Pasko, Marzanna, Piskorz, Wiktoria Monika   +3 more
core   +1 more source