Results 91 to 100 of about 767 (193)

Multiple effects of CDK4/6 inhibition in cancer: From cell cycle arrest to immunomodulation [PDF]

, 2019
Dysregulation of the cell cycle is a hallmark of cancer that leads to aberrant cellular proliferation. CDK4/6 are cyclin-dependent kinases activated in response to proliferative signaling, which induce RB hyper-phosphorylation and hence activation of E2F
Alfieri R., Bonelli M., Fumarola C., La Monica S.   +3 more
core   +1 more source

The Interplay of Aging and Cancer: Mechanisms, Implications, and Therapeutic Strategies

MedComm – Oncology, Volume 4, Issue 3, September 2025.
Aging and cancer form a vicious cycle: aging alters the tumor microenvironment, promotes senescence, and reshapes cancer progression and therapy response. In return, cancer and its treatments accelerate aging through inflammation and genomic damage. Novel strategies‐senolytics, CAR‐T, and artificial intelligence‐offer exciting opportunities to disrupt ...
Liangce Wang, Yaru Luo, Xin Chen, Yuan Wang, Yan Zhang   +4 more
wiley   +1 more source

A Senolytic Strategy for Metabolic Health: Why the Endothelium Matters

iNew Medicine, Volume 2, Issue 1, March 2026.
He Liang, Yu Wang, Yang Zhang, Xiaoqiang Tang   +3 more
wiley   +1 more source

Pyrroloquinoline Quinone Is an Effective Senomorphic Agent to Target the Pro‐Inflammatory Phenotype of Senescent Cells

Aging Cell, Volume 24, Issue 9, September 2025.
As a natural senomorphic agent, PQQ targets the intracellular molecule. HSPA8 of senescent cells, resulting in significantly reduced expression of the SASP. PQQ holds prominent potential to delay chronological aging and ameliorate age‐related conditions by acting as an effective senomorphic agent.
Birong Jiang, Hongwei Zhang, Qixia Xu, Zhirui Jiang, Ruikun He, Qiang Fu, Yu Sun   +6 more
wiley   +1 more source

β‐Galactosidase Based Molecular Imaging for Visualization of Cellular Senescence

iRADIOLOGY, Volume 4, Issue 1, Page 63-65, February 2026.
Jiani Huang, Peili Cen, Hong Zhang, Yan Zhong   +3 more
wiley   +1 more source

Autophagy and Cellular Senescence in Alzheimer's Disease: Key Drivers of Neurodegeneration

CNS Neuroscience &Therapeutics, Volume 31, Issue 7, July 2025.
Impaired autophagy in Alzheimer's disease leads to accumulation of amyloid‐β and tau aggregates, while senescent brain cells secrete pro‐inflammatory SASP factors. The interplay between defective clearance and chronic inflammation accelerates neuronal dysfunction and highlights autophagy enhancers and senolytics as promising therapeutic strategies ...
Md Sadique Hussain, Neetu Agrawal, Baby Ilma, Rekha M M, Priya Priyadarshini Nayak, Mandeep Kaur, Anil Khachi, Kavita Goyal, Arcot Rekha, Saurabh Gupta, Gaurav Gupta, Kamal Dua   +11 more
wiley   +1 more source

Accelerated Cellular Senescence in Progressive Multiple Sclerosis: A Histopathological Study

Annals of Neurology, Volume 97, Issue 6, Page 1074-1087, June 2025.
Objective The neurodegenerative processes driving the build‐up of disability in progressive multiple sclerosis (P‐MS) have not been fully elucidated. Recent data link cellular senescence (CS) to neurodegeneration. We investigated for evidence of CS in P‐MS and sought to determine its pattern.
Dimitrios Papadopoulos, Roberta Magliozzi, Sara Bandiera, Ilaria Cimignolo, Elena Barusolo, Lesley Probert, Vassilis Gorgoulis, Richard Reynolds, Richard Nicholas   +8 more
wiley   +1 more source

Targeting ATF6α Attenuates UVB‐Induced Senescence and Improves Skin Homeostasis by Regulating IL8 Expression

Aging Cell, Volume 24, Issue 6, June 2025.
UVB exposure can trigger senescence in dermal fibroblasts. We show that silencing ATF6α disrupts the establishment of the UVB‐induced senescent phenotype by preventing the onset of several senescent biomarkers and altering the composition of the SASP, consequently affecting its impact on the skin microenvironment.
Joëlle Giroud, Pauline Delvaux, Laura Carlier, Clémentine De Schutter, Nathalie Martin, Raphaël Rouget, Ayeh Bolouki, Valérie De Glas, Inès Bouriez, Florent Bourdoux, Sophie Burteau, Julien Théry, Gauthier Decanter, Nicolas Penel, Yvan de Launoit, Benjamin Ledoux, Corinne Abbadie, Yves Poumay, Olivier Pluquet, Florence Debacq‐Chainiaux   +19 more
wiley   +1 more source

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

Advanced Science, Volume 12, Issue 20, May 29, 2025.
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang, Qixia Xu, Zhirui Jiang, Rong Sun, Qun Wang, Sanhong Liu, Xin Luan, Judith Campisi, James L. Kirkland, Weidong Zhang, Yu Sun   +10 more
wiley   +1 more source

Telomere stabilization by metformin mitigates the progression of atherosclerosis via the AMPK-dependent p-PGC-1α pathway

Experimental and Molecular Medicine
Telomere dysfunction is a well-known molecular trigger of senescence and has been associated with various age-related diseases, including atherosclerosis.
Jin Young Sung, Seul Gi Kim, So-Young Park, Jae-Ryong Kim, Hyoung Chul Choi   +4 more
doaj   +1 more source