Results 91 to 100 of about 646 (170)

The Dynamic Process and Its Dual Effects on Tumors of Therapy-Induced Senescence

Cancer Management and Research, 2020
Chenxi Liao,1,* Yin Xiao,2,* Lingbo Liu1 1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People’s Republic of China; 2Cancer Center, Union Hospital, Tongji Medical ...
Liao C, Xiao Y, Liu L
doaj  

Characterization of the HDAC/PI3K inhibitor CUDC-907 as a novel senolytic

, 2023
The accumulation of senescent cells has an important role in the phenotypical changes observed in ageing and in many age-related pathologies. Thus, the strategies designed to prevent these effects, collectively known as senotherapies, have a strong ...
M Poblocka (7809785), A Saleh (9864761), W Alzahrani (15431402), S Macip (7713152), F Al-Mansour (15431396), B He (9248990), S Cowley (7706078), A Alraddadi (15431399)   +7 more
core   +1 more source

Senescence and senotherapies in pediatric biliary cirrhosis

, 2023
Premature senescence worsens the prognosis of adult chronic hepatobiliary diseases and some evidence suggests that this phenomenon also occurs in biliary atresia, which is the leading cause of pediatric liver transplantation. Since alternatives to liver transplantation are still lacking, the aim of our work was to investigate premature senescence in ...
openaire   +1 more source

Cellular senescence in renal ageing and disease

, 2017
Item does not contain fulltextThe senescence programme is implicated in diverse biological processes, including embryogenesis, tissue regeneration and repair, tumorigenesis, and ageing.
Deursen, J.M.A. van, Jan M. van Deursen, Baker, D.J., Sturmlechner, Ines, Cynthia J. Sieben, van Deursen, Jan M., Ines Sturmlechner, Darren J. Baker, Sieben, Cynthia J., Sieben, C.J., Matej Durik, Durik, M., Baker, Darren J., Sturmlechner, Ines; id_orcid, Sturmlechner, I., Durik, Matej   +15 more
core   +1 more source

Cellular senescense: an overview on characteristics, effects and senotherapy

Cellular senescence is defined as part of the aging process that can be found throughout the life cycle and, i tis linked to age-related chronic pathologies like diabetes, Alzheimer’s, Osteoporosis, Cancer and many others.
Ferreira, Patrícia dos Santos
core  

Therapy-induced senescence in prostate cancer: mechanisms, therapeutic strategies, and clinical implications [PDF]

Cellular senescence; Prostate cancer; Senescence-associated secretory phenotypeSenescència cel·lular; Càncer de pròstata; Fenotip secretor associat a la senescènciaSenescencia celular; Cáncer de próstata; Fenotipo secretor asociado a la ...
Labbé, David, Brandariz, Julian, Zacchi, Francesca, Zivi, Andrea, Bacca, Luisa, Mateo, Joaquin   +5 more
core   +1 more source

The autophagy-senescence axis as a threshold model of aging and therapeutic targeting

Redox Biology
Autophagy and cellular senescence are fundamental stress-response programs that critically shape aging and disease progression, yet their functional relationship has remained paradoxical. Autophagy is traditionally viewed as a cytoprotective process that
Md Entaz Bahar, Jin Seok Hwang, Trang Huyen Lai, Kazi-Marjahan Akter, Rizi Firman Maulidi, Deok Ryong Kim   +5 more
doaj   +1 more source

Cellular senescence in the aging and diseased kidney

, 2017
The program of cellular senescence is involved in both the G1 and G2 phase of the cell cycle, limiting G1/S and G2/M progression respectively, and resulting in prolonged cell cycle arrest. Cellular senescence is involved in normal wound healing. However,
F. A. Valentijn, T. Q. Nguyen, Valentijn, F A, Falke, L L, Roel Goldschmeding, L. L. Falke, Nguyen, T Q, Goldschmeding, Roel   +7 more
core   +1 more source

Consequences of senotherapies for tissue repair and reprogramming

Translational Medicine of Aging, 2019
Van Vliet, T., Kohli, J., Demaria, M.
openaire   +2 more sources

Cholesterol accumulation promotes photoreceptor senescence and retinal degeneration

PURPOSE: Dysregulated cholesterol metabolism is critical in the pathogenesis of AMD. Cellular senescence contributes to the development of numerous age-associated diseases.
Lee, Tae Jun, Santeford, Andrea, Terao, Ryo, Colasanti, Jason, Lin, Joseph B, Yamaguchi, Shinobu, Sohn, Brian S, Yamamoto, Taku, Pfeifer, Charles W, Yoshida, Mitsukuni, Apte, Rajendra S   +10 more
core   +1 more source