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2018
Aging brings about many risks factors that can lead to age-related chronic disorders such as atherosclerosis, osteoporosis, and neurodegenerative diseases. Implicated in aging and age-related pathologies, the accumulation of senescent cells can prevent tissue repair and regeneration, leading to loss of physiological function.
Janice Wong +3 more
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Aging brings about many risks factors that can lead to age-related chronic disorders such as atherosclerosis, osteoporosis, and neurodegenerative diseases. Implicated in aging and age-related pathologies, the accumulation of senescent cells can prevent tissue repair and regeneration, leading to loss of physiological function.
Janice Wong +3 more
openaire +1 more source
[Senotherapy: Advances and new clinical perspectives].
Medecine sciences : M/S, 2021Cellular senescence has been now shown to be at the root of many degenerative processes that characterize ageing. Thus, in addition to an irreversible proliferative arrest following various stresses or inappropriate stimuli, cellular senescence leads to genetic, epigenetic, metabolic, structural and functional adaptations of the cell.
Damien, Veret, Jean-Marc, Brondello
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The potential for senotherapy as a novel approach to extend life quality in veterinary medicine
Frontiers in Veterinary ScienceCellular senescence, a condition where cells undergo arrest and can assume an inflammatory phenotype, has been associated with initiation and perpetuation of inflammation driving multiple disease processes in rodent models and humans. Senescent cells secrete inflammatory cytokines, proteins, and matrix metalloproteinases, termed the senescence ...
Lyndah Chow
exaly +4 more sources
Senotherapy: A New Horizon for COPD Therapy.
Chest, 2021There is increasing evidence that COPD is a disease of accelerated lung aging, with the accumulation of senescent cells that lose their ability to repair and secrete multiple inflammatory proteins known as the senescence-associated secretory phenotype (SASP), which mimic the profile of inflammatory mediators secreted in COPD.
Jonathan R, Baker +2 more
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Lineage-guided senescence insights unlock precision senotherapy
Aging ResearchTingbo Liang
exaly +2 more sources
Proteolysis targeting chimeras as senolytics: An emerging senotherapy for combating aging
The Journal of Pharmacology and Experimental TherapeuticsCellular senescence, a persistent state of cell cycle arrest, accumulates in aged organisms, contributes to tissue dysfunction, and drives aging-related phenotypes. Clearance of senescent cells decreases chronic, low-grade inflammation and restores tissue repair capacity, thus improving human health and lifespan.
Alexis B. Cruickshank-Taylor +4 more
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Apoptosis-coupled senescence causes cancer cell senotherapy
2023Abstract Although new generations of anti-cancer modalities have been accumulated involving immuno-oncology cancers remain prevailing. This implies the current understanding of cancer cell biology is far from satisfactory. Curation of cancers is extremely rare.
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Biochemical Society Transactions
Cellular senescence, a form of terminal cell cycle arrest, is as a key driver of organismal ageing and an important factor in age-related diseases. Insights into the senescent phenotype have led to the development of novel therapeutic strategies, collectively known as senotherapies, that aim to ameliorate the detrimental effects of senescent cell ...
Vinesh Dhokia +4 more
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Cellular senescence, a form of terminal cell cycle arrest, is as a key driver of organismal ageing and an important factor in age-related diseases. Insights into the senescent phenotype have led to the development of novel therapeutic strategies, collectively known as senotherapies, that aim to ameliorate the detrimental effects of senescent cell ...
Vinesh Dhokia +4 more
openaire +2 more sources