Inflammaging as a Druggable Target: A Senescence-Associated Secretory Phenotype - Centered View of Type 2 Diabetes [PDF]
, 2016 Aging is a complex phenomenon driven by a variety of molecular alterations. A relevant feature of aging is chronic low-grade inflammation, termed "inflammaging." In type 2 diabetes mellitus (T2DM), many elements of aging appear earlier or are ...
Ceriello A. +5 more
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Decreased SIRT1 Impairs HIF-1α Nuclear Translocation in Alveolar Epithelial Cells: A Potential Mechanism of Emphysema Progression [PDF]
Hypoxia-inducible factor 1 (HIF-1) is a crucial protein involved in cellular adaptation to low oxygen levels. We previously demonstrated impaired HIF-1α nuclear translocations cause impaired cellular adaptation to hypoxia in chronic obstructive pulmonary
Arimoto, Yoshihito +4 more
core +1 more source
Bst2-targeted senotherapy restores visual function by eliminating senescent retinal cells
Nature CommunicationsSenescent cells contribute to degenerative processes in multiple tissues, including the retina. In the retinal pigment epithelium (RPE), their accumulation is closely associated with retinal aging and disease progression.
Jun Yong Oh +15 more
doaj +1 more source
Prognostic significance of a signature based on senescence-related genes in colorectal cancer [PDF]
Colorectal cancer, recognized as a quintessential age-related disease, underscores the intricate interplay between aging mechanisms and disease pathogenesis.
Bianchini G. +3 more
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Advances in acid-degradable and enzyme-cleavable linkers for drug delivery. [PDF]
Drug delivery vectors have the potential to improve the efficacy of therapeutics, including small molecules and nucleic acid-based drugs. However, challenges remain in developing linkages that enable the precise and efficient release of therapeutic cargo
Guo, Shutao +4 more
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Frontiers in GeneticsVascular diseases pose major health challenges, and understanding their underlying molecular mechanisms is essential to advance therapeutic interventions. Cellular senescence, a hallmark of aging, is a cellular state characterized by cell-cycle arrest, a
Oscar Fraile-Martinez +31 more
doaj +1 more source
The autophagy-senescence axis as a threshold model of aging and therapeutic targeting
Redox BiologyAutophagy and cellular senescence are fundamental stress-response programs that critically shape aging and disease progression, yet their functional relationship has remained paradoxical. Autophagy is traditionally viewed as a cytoprotective process that
Md Entaz Bahar +5 more
doaj +1 more source
Senolytic therapy reduces inflammation in epithelial cells from COPD patients and in smoke-exposure mice [PDF]
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is a disease of accelerated lung aging, with increased numbers of senescent cells found within the COPD Lung.
Baker, Jonathan R +6 more
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Therapy-induced senescence in prostate cancer: mechanisms, therapeutic strategies, and clinical implications [PDF]
Cellular senescence; Prostate cancer; Senescence-associated secretory phenotypeSenescència cel·lular; Càncer de pròstata; Fenotip secretor associat a la senescènciaSenescencia celular; Cáncer de próstata; Fenotipo secretor asociado a la ...
Bacca, Luisa +5 more
core +1 more source
Gut microbiota-dependent increase in phenylacetic acid induces endothelial cell senescence during aging [PDF]
Endothelial cell senescence is a key driver of cardiovascular aging, yet little is known about the mechanisms by which it is induced in vivo. Here we show that the gut bacterial metabolite phenylacetic acid (PAA) and its byproduct, phenylacetylglutamine (
Alimonti, Andrea +20 more
core +4 more sources