Results 101 to 110 of about 767 (193)

From Lasers to Longevity: Exploring Energy-Based Devices as Senotherapeutic Tools in Dermatology

Cosmetics
Background: Cutaneous aging is a multifactorial process, increasingly understood through the lens of cellular senescence, a state of stable cell cycle arrest accompanied by a pro-inflammatory secretory phenotype that disrupts tissue homeostasis.
Oana Mihaela Condurache Hrițcu, Victor-Vlad Costan, Ștefan Vasile Toader, Daciana Elena Brănișteanu, Mihaela Paula Toader   +4 more
doaj   +1 more source

Ptychographic analysis of human bone marrow-derivedmesenchymal stem cell morphology: The impact of cellsenescence [PDF]

Mesenchymal stem cells (MSC) undergo replicative senescence, a state of irreversible cell cycle arrest that limits their utility in regenerative medicine applications.
F. Borsetti, F. Rossi, G. Farruggia, I. Zafferri, J. A. Maier, L. Anconelli, S. Iotti   +6 more
core   +1 more source

Cellular Senescence: Defining a Path Forward. [PDF]

, 2019
Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as
Adams, Peter D, Alimonti, Andrea, Bennett, Dorothy C, Bischof, Oliver, Bishop, Cleo, Campisi, Judith, Collado, Manuel, Demaria, Marco, Evangelou, Konstantinos, Ferbeyre, Gerardo, Gil, Jesús, Gorgoulis, Vassilis, Hara, Eiji, Jurk, Diana, Krizhanovsky, Valery, Maier, Andrea B, Narita, Masashi, Niedernhofer, Laura, Passos, João F, Robbins, Paul D, Schmitt, Clemens A, Sedivy, John, Serrano, Manuel, von Zglinicki, Thomas, Vougas, Konstantinos, Zhou, Daohong   +25 more
core   +10 more sources

Editorial: The Role of Cellular Senescence in Health and Disease

Frontiers in Cellular Neuroscience, 2022
Ignacio Palmero, Vassilis Gorgoulis, Vassilis Gorgoulis, Vassilis Gorgoulis, Vassilis Gorgoulis, Vassilis Gorgoulis, Isabel Varela-Nieto, Isabel Varela-Nieto, Isabel Varela-Nieto   +8 more
doaj   +1 more source

Senotherapeutic Potential of Araliadiol in Senescent Human Dermal Fibroblasts: An In Vitro Study Using Three Senescence Models

Pharmaceutics
Background/Objectives: With the rapid aging of the global population, the interest in therapies for age-related diseases has increased substantially. The skin is particularly important, as aging-related changes are visible and negatively impact quality ...
Seokmuk Park, Seyeol Baek, Hee-Jae Shin, Jeong Yi Hwang, Dae Sung Yoo, Dae Bang Seo, Seunghee Bae   +6 more
doaj   +1 more source

Protective factors against oxidative stress in COPD: focus on Nrf2-dependent antioxidant gene expression [PDF]

Chronic obstructive pulmonary disease (COPD) continues to be the world’s primary cause of morbidity and mortality. The main mechanism driving the pathogenesis of COPD is oxidative stress.
Eva Kominkova, Martin Petrek, Zdenka Navratilova   +2 more
core   +1 more source

The Dynamic Process and Its Dual Effects on Tumors of Therapy-Induced Senescence

Cancer Management and Research, 2020
Chenxi Liao,1,* Yin Xiao,2,* Lingbo Liu1 1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People’s Republic of China; 2Cancer Center, Union Hospital, Tongji Medical ...
Liao C, Xiao Y, Liu L
doaj  

Senescence and senotherapies in pediatric biliary cirrhosis

, 2023
Premature senescence worsens the prognosis of adult chronic hepatobiliary diseases and some evidence suggests that this phenomenon also occurs in biliary atresia, which is the leading cause of pediatric liver transplantation. Since alternatives to liver transplantation are still lacking, the aim of our work was to investigate premature senescence in ...
openaire   +1 more source

Recycling senescent cell lipids for targeted senotherapy

Nature Communications
Senescent cells (SnCs) are increasingly recognized as key contributors to osteoarthritis, with conventional strategies centered on their elimination.
Xiaoxiao Ji, Xingzi He, Honglu Cai, Peng Tang, Hao Zhou, Jiajie Wang, Yifan Wu, Jinfeng Zhou, Zhang Lin, Kaicheng Xu, Changjian Lin, Xiaoyong Wu, Kanbin Wang, Wangmi Liu, Gang Feng, Shigui Yan, Guangyao Jiang, Zihao Qu, Yiying Qi   +18 more
doaj   +1 more source

The costs and benefits of senotherapeutics for human health [PDF]

Cellular senescence is a major contributor to age-related diseases in humans; however, it also has a beneficial role in physiological and pathological processes, including wound healing, host immunity, and tumour suppression.
Raffaele, M, Vinciguerra, M
core   +1 more source