Results 101 to 110 of about 276 (129)

Senotherapy: growing old and staying young?

Pflugers Archiv European Journal of Physiology, 2017
Cellular senescence, which has been linked to age-related diseases, occurs during normal aging or as a result of pathological cell stress. Due to their incapacity to proliferate, senescent cells cannot contribute to normal tissue maintenance and tissue repair.
Roland Schmitt
exaly   +4 more sources

Treating Senescence like Cancer: Novel Perspectives in Senotherapy of Chronic Diseases [PDF]

International Journal of Molecular Sciences, 2020
The WHO estimated around 41 million deaths worldwide each year for age-related non-communicable chronic diseases. Hence, developing strategies to control the accumulation of cell senescence in living organisms and the overall aging process is an urgently needed problem of social relevance.
Sandra Atlante, Veronica Barbi, Alessia Mongelli   +2 more
exaly   +5 more sources

Targeting normal and cancer senescent cells as a strategy of senotherapy

Ageing Research Reviews, 2019
Senotherapy is an antiageing strategy. It refers to selective killing of senescent cells by senolytic agents, strengthening the activity of immune cells that eliminate senescent cells or alleviating the secretory phenotype (SASP) of senescent cells. As senescent cells accumulate with age and are considered to be at the root of age-related disorders ...
Grazyna Mosieniak, Ewa Sikora, Anna Bielak-Żmijewska   +2 more
exaly   +4 more sources

Targeted delivery strategy: A beneficial partner for emerging senotherapy

Biomedicine and Pharmacotherapy, 2022
Numerous cutting-edge studies have confirmed that the slow accumulation of cell cycle arrested and secretory cells, called senescent cells (SCs), in tissues is an important negative factor, or even the culprit, in age- associated diseases such as non-alcoholic fatty liver, Alzheimer's disease, type 2 diabetes, atherosclerosis, and malignant tumors ...
Qixiong Zhang, Rui Zeng
exaly   +3 more sources

Senotherapy preserves resilience in aging

Geriatrics and Gerontology International
In aging societies, social and economic burdens of aging‐related diseases are increasing significantly. Senotherapy, which targets aging by eliminating senescent cells (senolytics) or removing sources of chronic inflammation (senostatics), are proposed as novel strategies for aging‐related diseases.
Hiroshi Kondoh
exaly   +5 more sources

Senotherapy for chronic lung disease

Pharmacological Reviews
Chronic respiratory diseases are an enormous burden on healthcare and the third ranked cause of death globally. There is now compelling evidence that acceleration of lung aging and associated cellular senescence is a key driving mechanism of several chronic lung diseases, particularly chronic obstructive pulmonary disease and idiopathic pulmonary ...
Pj Barnes
exaly   +4 more sources

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Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies

Pharmacological Reviews, 2023
An increase in life expectancy in developed countries has led to a surge of chronic aging-related diseases. In the last few decades, several studies have provided evidence of the prominent role of cellular senescence in many of these pathologies. Key traits of senescent cells include cell cycle arrest, apoptosis resistance, and secretome shift to ...
Lucas, Vasco, Cavadas, Cláudia, Aveleira, Célia Alexandra   +2 more
openaire   +2 more sources

Senotherapy for lung diseases

2023
Increasing evidence suggests that there is acceleration of lung ageing in chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF), with the accumulation of senescent cells in the lung. Senescent cells fail to repair tissue damage and release an array of inflammatory proteins, known as the ...
openaire   +2 more sources

Senotherapies: A novel strategy for synergistic anti-tumor therapy

Drug Discovery Today, 2022
Cellular senescence was initially considered an effective antitumor mechanism, and senescence-induced therapy has previously been regarded as an efficient treatment. However, increasing studies have discovered that persistent senescent cells (SNCs) might have unanticipated negative repercussions for antitumor treatment.
Xuxin, Qi, Li, Jiang, Ji, Cao
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Senotherapy: Implications for Transplantation

Transplantation
Cellular senescence has been identified as a potential driver of age-associated loss of organ function and as a mediator of age-related disease. Novel strategies in targeting senescent cells have shown promise in several organ systems to counteract functional decline, chronic inflammation, and age-dependent loss of repair capacity.
Martin, Jaros, Anette, Melk
openaire   +2 more sources