Results 101 to 110 of about 646 (170)

The right time, the right cell: the potential for precision senotherapy in pulmonary arterial hypertension. [PDF]

Am J Physiol Lung Cell Mol Physiol
Hirsch K, Horn AG, Donato AJ, Schulze KM.   +3 more
europepmc   +1 more source

Senoprevention and senotherapy – new pharmacological strategies for age-related diseases?

Farmacja Polska
Starzenie organizmu jest procesem, który zależy od wielu czynników, a charakterystyczne cechy starzenia się ujawniają swój postęp na trzech różnych poziomach: molekularnym, komórkowym oraz systemowym. Starzenie komórek to złożony proces, regulowany czynnikami genetycznymi, epigenetycznymi i środowiskowymi, charakteryzujący wiele typów komórek ...
openaire   +1 more source

Targeting p21 for diabetes: Another choice of senotherapy

, 2023
Kondoh, Hiroshi, 近藤, 祥司, Hara, Eiji   +2 more
core  

Author Correction: Inhibition of serotonin-Htr2b signaling in skeletal muscle mitigates obesity-induced insulin resistance. [PDF]

Exp Mol Med
Park S, Kim H, Shin S, Kim Y, Kang Y, Cha HN, Park SY, Park S, Oh CM.   +8 more
europepmc   +1 more source

Cellular Senescence as a Risk Factor in Head and Neck Cancer-Diagnostic and Therapeutic Perspective. [PDF]

Cancers (Basel)
Stachowiak M, Kostrzewa M, Golusinski W, Golusinski P, Golusinska-Kardach E, Masternak MM, Rubiś B.   +6 more
europepmc   +1 more source

Systematic transcriptomic analysis and temporal modelling of human fibroblast senescence

Cellular senescence is a diverse phenotype characterised by permanent cell cycle arrest and an associated secretory phenotype (SASP) which includes inflammatory cytokines.
Pease, L., Rasmussen, L., O’Keefe, H., Martinez-Guimera, A., Wordsworth, J., Scanlan, R. L., Shanley, D.   +6 more
core   +1 more source

Cellular Senescence: Defining a Path Forward

, 2019
The cellular state of “senescence” has proven difficult to define, presenting an obstacle for progress in the field. This perspective provides a consensus on the cellular and molecular features of senescence from 26 field leaders.
Niedernhofer, L., Hara, E., Bishop, C., Vougas, K., Robbins, P.D., Campisi, J., Narita, M., Maier, A.B., Bennett, D.C., Gil, J., Bischof, O., Gorgoulis, V., Jurk, D., Adams, P.D., Krizhanovsky, V., Sedivy, J., Schmitt, C.A., Serrano, M., Passos, J.F., Demaria, M., von Zglinicki, T., Alimonti, A., Zhou, D., Evangelou, K., Collado, M., Ferbeyre, G.   +25 more
core  

'Glucocorticoids, Cushing's syndrome and cellular senescence: a mechanistic link to metabolic ageing'. [PDF]

Endocr Connect
Santillan CM, Abbas M, Macip S, Hanzu FA.   +3 more
europepmc   +1 more source

The drug discovery and therapeutic nano-strategies targeting cellular senescence. [PDF]

Mater Today Bio
Wang Y, Liu M, Chen X, Wang S, Li J, Sun Y, Zheng X, Zhang J, Li H.   +8 more
europepmc   +1 more source

SENESCENCE2030: Targeting Cell Senescence to Prevent Age-Related Diseases

Preventing or alleviating aging associated diseases, collectively rather than individually, is the challenge to extend the human healthspan. The knowledge on cellular and molecular mechanisms identified so far as “hallmarks of aging” allow ...
Miova, Biljana, Cerrato, Aniello, Maksimova, Viktorija, Smith, Ulf   +3 more
core