Results 81 to 90 of about 646 (170)

The Interplay of Aging and Cancer: Mechanisms, Implications, and Therapeutic Strategies

MedComm – Oncology, Volume 4, Issue 3, September 2025.
Aging and cancer form a vicious cycle: aging alters the tumor microenvironment, promotes senescence, and reshapes cancer progression and therapy response. In return, cancer and its treatments accelerate aging through inflammation and genomic damage. Novel strategies‐senolytics, CAR‐T, and artificial intelligence‐offer exciting opportunities to disrupt ...
Liangce Wang, Yaru Luo, Xin Chen, Yuan Wang, Yan Zhang   +4 more
wiley   +1 more source

A Senolytic Strategy for Metabolic Health: Why the Endothelium Matters

iNew Medicine, Volume 2, Issue 1, March 2026.
He Liang, Yu Wang, Yang Zhang, Xiaoqiang Tang   +3 more
wiley   +1 more source

Pyrroloquinoline Quinone Is an Effective Senomorphic Agent to Target the Pro‐Inflammatory Phenotype of Senescent Cells

Aging Cell, Volume 24, Issue 9, September 2025.
As a natural senomorphic agent, PQQ targets the intracellular molecule. HSPA8 of senescent cells, resulting in significantly reduced expression of the SASP. PQQ holds prominent potential to delay chronological aging and ameliorate age‐related conditions by acting as an effective senomorphic agent.
Birong Jiang, Hongwei Zhang, Qixia Xu, Zhirui Jiang, Ruikun He, Qiang Fu, Yu Sun   +6 more
wiley   +1 more source

Gut microbiota-dependent increase in phenylacetic acid induces endothelial cell senescence during aging [PDF]

Endothelial cell senescence is a key driver of cardiovascular aging, yet little is known about the mechanisms by which it is induced in vivo. Here we show that the gut bacterial metabolite phenylacetic acid (PAA) and its byproduct, phenylacetylglutamine (
Pugin, Benoit, Beer, Jürg H, Colucci, Manuel, Beer, J.H., Constancias, Florentin, Alimonti, Andrea, Menni, Cristina, Attaye, I., Zhang, Xinyuan, Falchi, M., Paneni, F., Le Gludic, S., Colucci, M., Shabanian, Khatereh, Saeedi Saravi, S.S., Pugin, B., Thomas, A., Menni, C., Allemann, Meret Sarah, Constancias, F., Shabanian, K., Spalinger, M., Karsai, G., Spalinger, Marianne, Shabanian, Taraneh, Ruschitzka, Frank, Thomas, Aurélien, Lee, P., Beer, Jürg H., Allemann, M.S., Visconti, Alessia, Le Gludic, Sylvain, Zhang, X., Lee, Pratintip, Shabanian, T., Alimonti, A., Attaye, Ilias, Paneni, Francesco, Visconti, A., Falchi, Mario; id_orcid, Saeedi Saravi, Seyed Soheil, Ruschitzka, F., Falchi, Mario, Karsai, Gergely   +43 more
core   +1 more source

β‐Galactosidase Based Molecular Imaging for Visualization of Cellular Senescence

iRADIOLOGY, Volume 4, Issue 1, Page 63-65, February 2026.
Jiani Huang, Peili Cen, Hong Zhang, Yan Zhong   +3 more
wiley   +1 more source

Telomere stabilization by metformin mitigates the progression of atherosclerosis via the AMPK-dependent p-PGC-1α pathway

Experimental and Molecular Medicine
Telomere dysfunction is a well-known molecular trigger of senescence and has been associated with various age-related diseases, including atherosclerosis.
Jin Young Sung, Seul Gi Kim, So-Young Park, Jae-Ryong Kim, Hyoung Chul Choi   +4 more
doaj   +1 more source

From Lasers to Longevity: Exploring Energy-Based Devices as Senotherapeutic Tools in Dermatology

Cosmetics
Background: Cutaneous aging is a multifactorial process, increasingly understood through the lens of cellular senescence, a state of stable cell cycle arrest accompanied by a pro-inflammatory secretory phenotype that disrupts tissue homeostasis.
Oana Mihaela Condurache Hrițcu, Victor-Vlad Costan, Ștefan Vasile Toader, Daciana Elena Brănișteanu, Mihaela Paula Toader   +4 more
doaj   +1 more source

Editorial: The Role of Cellular Senescence in Health and Disease

Frontiers in Cellular Neuroscience, 2022
Ignacio Palmero, Vassilis Gorgoulis, Vassilis Gorgoulis, Vassilis Gorgoulis, Vassilis Gorgoulis, Vassilis Gorgoulis, Isabel Varela-Nieto, Isabel Varela-Nieto, Isabel Varela-Nieto   +8 more
doaj   +1 more source

Senotherapeutic Potential of Araliadiol in Senescent Human Dermal Fibroblasts: An In Vitro Study Using Three Senescence Models

Pharmaceutics
Background/Objectives: With the rapid aging of the global population, the interest in therapies for age-related diseases has increased substantially. The skin is particularly important, as aging-related changes are visible and negatively impact quality ...
Seokmuk Park, Seyeol Baek, Hee-Jae Shin, Jeong Yi Hwang, Dae Sung Yoo, Dae Bang Seo, Seunghee Bae   +6 more
doaj   +1 more source

Senescence and Senolytics in Cardiovascular disease: Promise and Potential Pitfalls [PDF]

Ageing is the biggest risk factor for impaired cardiovascular health, with cardiovascular disease being the cause of death in 40% of individuals over 65 years old.
Spyridopoulos I, Owens WA, Richardson GD, Dookun E, Walaszczyk A   +4 more
core