Results 81 to 90 of about 276 (129)

Harnessing Natural Extracellular Vesicles to Combat Age-Related Diseases: From Aging Drivers to Therapeutic Opportunities

International Journal of Nanomedicine
Shijie Lv,1 Jirong Xie,1 Xin Huang,1,2 Zongshuai Liu,1 Junjie Shi,1 Zhengguo Cao,1,2 Zhengjun Shang1,31State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079,
Lv S, Xie J, Huang X, Liu Z, Shi J, Cao Z, Shang Z   +6 more
doaj  

Epigenetic dynamics of cellular senescence: From mechanistic insights to precision senotherapy

Chinese Medical Journal
. Cellular senescence functions as a pivotal stress response with dual roles; it serves as a barrier against early tumorigenesis while paradoxically driving late-stage tumor progression and the pathogenesis of many other age-related diseases, including ...
Xiangjun Hu, Weijing Lai, Mengyuan Liu, Bo Wang, Xuehong Zhang   +4 more
doaj   +1 more source

The Dynamic Process and Its Dual Effects on Tumors of Therapy-Induced Senescence

Cancer Management and Research, 2020
Chenxi Liao,1,* Yin Xiao,2,* Lingbo Liu1 1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People’s Republic of China; 2Cancer Center, Union Hospital, Tongji Medical ...
Liao C, Xiao Y, Liu L
doaj  

Gut microbiota-dependent increase in phenylacetic acid induces endothelial cell senescence during aging [PDF]

Endothelial cell senescence is a key driver of cardiovascular aging, yet little is known about the mechanisms by which it is induced in vivo. Here we show that the gut bacterial metabolite phenylacetic acid (PAA) and its byproduct, phenylacetylglutamine (
Pugin, Benoit, Beer, Jürg H, Colucci, Manuel, Beer, J.H., Constancias, Florentin, Alimonti, Andrea, Menni, Cristina, Attaye, I., Zhang, Xinyuan, Falchi, M., Paneni, F., Le Gludic, S., Colucci, M., Shabanian, Khatereh, Saeedi Saravi, S.S., Pugin, B., Thomas, A., Menni, C., Allemann, Meret Sarah, Constancias, F., Shabanian, K., Spalinger, M., Karsai, G., Spalinger, Marianne, Shabanian, Taraneh, Ruschitzka, Frank, Thomas, Aurélien, Lee, P., Beer, Jürg H., Allemann, M.S., Visconti, Alessia, Le Gludic, Sylvain, Zhang, X., Lee, Pratintip, Shabanian, T., Alimonti, A., Attaye, Ilias, Paneni, Francesco, Visconti, A., Falchi, Mario; id_orcid, Saeedi Saravi, Seyed Soheil, Ruschitzka, F., Falchi, Mario, Karsai, Gergely   +43 more
core   +1 more source

Plant-Derived Senotherapeutics in Cellular Senescence: A Scoping Review of Preclinical Evidence, Mechanistic Pathways, and Metabolomic-Guided Discovery

Senotherapeutic agents targeting senescent cell (SnC) accumulation represent a promising frontier in aging research. These agents encompass senolytics that selectively eliminate accumulated SnCs and senomorphics that suppress the pathological persistence
Nor Muhammad Hilmi Hussin, Rahma Micho Widyanto, Ahmed Mediani, Razinah Sharif, Michael Fenech, Normala Abd Latip   +5 more
core   +1 more source

The Physical Senotype in Cellular Senescence: Mechanical and Physical Strategies for Senotherapy

Ageing Research Reviews
Bingjie Wang, Xiangqing Qi, Johnny Huard, Xiaodong Mu   +3 more
openaire   +2 more sources

Bst2-targeted senotherapy restores visual function by eliminating senescent retinal cells

Nature Communications
Senescent cells contribute to degenerative processes in multiple tissues, including the retina. In the retinal pigment epithelium (RPE), their accumulation is closely associated with retinal aging and disease progression.
Jun Yong Oh, Jae-Byoung Chae, Hyo Kyung Lee, Chul-Woo Park, Minseo Bae, Gyuri Kim, Yujeong Oh, Gyeongseok Yang, Sangpil Kim, Hae Won Ok, Dohyun Kim, Chaekyu Kim, Semin Lee, Jiwon Jang, Hyewon Chung, Ja-Hyoung Ryu   +15 more
doaj   +1 more source

The autophagy-senescence axis as a threshold model of aging and therapeutic targeting

Redox Biology
Autophagy and cellular senescence are fundamental stress-response programs that critically shape aging and disease progression, yet their functional relationship has remained paradoxical. Autophagy is traditionally viewed as a cytoprotective process that
Md Entaz Bahar, Jin Seok Hwang, Trang Huyen Lai, Kazi-Marjahan Akter, Rizi Firman Maulidi, Deok Ryong Kim   +5 more
doaj   +1 more source

A novel senotherapeutic strategy with azithromycin for preventing endometriosis progression

Reproductive Biology and Endocrinology
Background Endometriosis is an estrogen-dependent chronic inflammatory disease, however the mechanisms underlying inflammation remain unclear. Non-hormonal drugs that can prevent endometriosis progression and resolve endometriotic infertility are ...
Reina Sonehara, Tomoko Nakamura, Takehiko Takeda, Satoshi Kaseki, Tomomi Seki, Hideaki Tanaka, Atsushi Yabuki, Natsuki Miyake, Ayako Muraoka, Satoko Osuka, Akira Iwase, Hiroaki Kajiyama   +11 more
doaj   +1 more source

Adoptive NK cell therapy: a potential revolutionary approach in longevity therapeutics

Immunity & Ageing
The aging process intricately involves immune system dynamics, with a crucial role in managing senescent cells (SNCs) and their senescence-associated secretory phenotypes (SASPs).
Xuewen Deng, Hiroshi Terunuma
doaj   +1 more source