Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities
Advanced Science, 2020 Aging is a physiological decline in both structural homeostasis and functional integrity, progressively affecting organismal health. A major hallmark of aging is the accumulation of senescent cells, which have entered a state of irreversible cell cycle ...
Shuling Song +4 more
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Can statin preventative treatment inform geroscience-guided therapeutics? [PDF]
, 2023 : Potential senotherapeutic effect of statins may lead to prevention and reduction of ...
Erlandson, Kristine M +4 more
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Senescence and Cancer: A Review of Clinical Implications of Senescence and Senotherapies [PDF]
Cancers, 2020 Cellular senescence is a key component of human aging that can be induced by a range of stimuli, including DNA damage, cellular stress, telomere shortening, and the activation of oncogenes. Senescence is generally regarded as a tumour suppressive process, both by preventing cancer cell proliferation and suppressing malignant progression from pre ...
Wyld, L. +8 more
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Cellular Senescence in Lung Fibrosis [PDF]
, 2021 Fibrosing interstitial lung diseases (ILDs) are chronic and ultimately fatal age-related lung diseases characterized by the progressive and irreversible accumulation of scar tissue in the lung parenchyma.
Agustí García-Navarro, Àlvar +5 more
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Cellular Senescence and Senotherapies in the Kidney: Current Evidence and Future Directions [PDF]
Frontiers in Pharmacology, 2020 Cellular senescence refers to a cellular phenotype characterized by an altered transcriptome, pro-inflammatory secretome, and generally irreversible growth arrest. Acutely senescent cells are widely recognized as performing key physiological functions in vivo promoting normal organogenesis, successful wound repair, and cancer defense.
Marie Helena Docherty +7 more
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An evaluation of the role of miR-361-5p in senescence and systemic ageing
Experimental Gerontology, 2023 Senescent cells are key regulators of ageing and age-associated disease. MicroRNAs (miRs) are a key component of the molecular machinery governing cellular senescence, with several known to regulate important genes associated with this process.We sought ...
Emad Manni +5 more
doaj +1 more source
Long-term cardiovascular complications following sepsis: is senescence the missing link?
Annals of Intensive Care, 2021 Highlights With improved management of patients, sepsis survivors are increasing each year. Early cardiovascular complications, of yet undeciphered mechanisms, are an emerging health issue in post-sepsis syndrome.
Hamid Merdji +3 more
doaj +1 more source
Cellular Senescence and Immunosenescence in Melanoma: Insights From the Tumor Microenvironment. [PDF]
Cancer MedABSTRACT Background Melanoma is one of the most immunogenic malignancies, yet resistance to immune checkpoint inhibitors (ICIs) remains a major obstacle to durable therapeutic success. Emerging evidence indicates that aging‐related processes, including cellular senescence and immunosenescence, can reshape the tumor microenvironment (TME) to favor ...
Xiong L, Cheng J.
europepmc +2 more sources
Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration [PDF]
Journal of Neuroinflammation, 2021 AbstractAge-related macular degeneration (AMD), a degenerative disease in the central macula area of the neuroretina and the supporting retinal pigment epithelium, is the most common cause of vision loss in the elderly. Although advances have been made, treatment to prevent the progressive degeneration is lacking.
Keng Siang Lee +4 more
openaire +5 more sources
A systematic scoping review of vascular cell senescence in atherosclerosis: An innovative perspective and therapeutic approach [PDF]
, 2023 A senescência celular é um processo complexo caracterizado pela incapacidade das células de se dividirem, o que acaba por comprometer a função celular. Quando este processo ocorre em células vasculares, os eventos protrombóticos, pró-inflamatórios, e pró-
José Alexander dos Santos de Canha
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