Results 51 to 60 of about 646 (170)
Senescence and Cancer: Role of Nitric Oxide (NO) in SASP
, 2020 Cellular senescence is a cell state involved in both physiological and pathological processes such as age-related diseases and cancer. While the mechanism of senescence is now well known, its role in tumorigenesis still remains very controversial.
Stéphanie Plenchette +5 more
core +1 more source
Virus-like nanoparticles as a theranostic platform for cancer
Frontiers in Bioengineering and Biotechnology, 2023 Virus-like nanoparticles (VLPs) are natural polymer-based nanomaterials that mimic viral structures through the hierarchical assembly of viral coat proteins, while lacking viral genomes.
Kyeong Rok Kim +5 more
doaj +1 more source
Human MSC-Derived Exosomes Reduce Cellular Senescence in Renal Epithelial Cells
, 2021 Cellular senescence of renal tubular cells is associated with chronic diseases and age-related kidney disorders. Therapies to antagonize senescence are, therefore, explored as novel approaches in nephropathy.
Ralf Hass +5 more
core +1 more source
Frontiers in Endocrinology, 2022 Increased insulin resistance and impaired insulin secretion are significant characteristics manifested by patients with type 2 diabetes mellitus (T2DM). The degree and extent of these two features in T2DM vary among races and individuals.
Takaaki Murakami +3 more
doaj +1 more source
Senescent cells: a therapeutic target for cardiovascular disease [PDF]
, 2018 Cellular senescence, a major tumor-suppressive cell fate, has emerged from humble beginnings as an in vitro phenomenon into recognition as a fundamental mechanism of aging.
Childs, B.G. +5 more
core +1 more source
Advanced Science, EarlyView.The biomimetic self‐assembly nanomedicine reversing atherosclerosis via senotherapy strategy. ABSTRACT The greatest challenge in atherosclerosis (AS) management lies in achieving lesion reversal, not merely slowing progression. Senescent cell accumulation—driven by continuous generation and apoptotic resistance—perpetuates plaque pathology and ...
Yuhan Tian +9 more
wiley +1 more source
Diverse Roles of Cellular Senescence in Skeletal Muscle Inflammation, Regeneration, and Therapeutics
Frontiers in Pharmacology, 2021 Skeletal muscle undergoes vigorous tissue remodeling after injury. However, aging, chronic inflammatory diseases, sarcopenia, and neuromuscular disorders cause muscle loss and degeneration, resulting in muscular dysfunction.
Yuki Saito +2 more
doaj +1 more source
Therapy-Induced Stromal Senescence Promoting Aggressiveness of Prostate and Ovarian Cancer [PDF]
, 2022 Cancer progression is supported by the cross-talk between tumor cells and the surrounding stroma. In this context, senescent cells in the tumor microenvironment contribute to the development of a pro-inflammatory milieu and the acquisition of aggressive ...
Pietro Spatafora +35 more
core +1 more source
Smooth muscle cell-specific deletion of TXNIP ameliorates medial vascular calcification
Experimental and Molecular MedicineVascular calcification is an important pathological characteristic of cardiovascular diseases, often exacerbated by metabolic disorders such as chronic kidney disease and diabetes mellitus.
Ae-Rang Hwang, Chang-Hoon Woo
doaj +1 more source
Epilepsia, EarlyView.Abstract Objective Current pharmacotherapy for temporal lobe epilepsy (TLE) is limited to symptomatic treatment and leaves approximately one third of patients with inadequate seizure control. Discovering disease‐modifying targets is an unmet clinical need. We have previously identified senescent cells (SCs) as one such target. Many drugs that eliminate
David J. McFall +3 more
wiley +1 more source