Results 51 to 60 of about 276 (129)

Senescence and Cancer: Role of Nitric Oxide (NO) in SASP

, 2020
Cellular senescence is a cell state involved in both physiological and pathological processes such as age-related diseases and cancer. While the mechanism of senescence is now well known, its role in tumorigenesis still remains very controversial.
Stéphanie Plenchette, Catherine Paul, Ali Bettaieb, Véronique Laurens, Silvia Ghione, Nesrine Mabrouk   +5 more
core   +1 more source

Diverse Roles of Cellular Senescence in Skeletal Muscle Inflammation, Regeneration, and Therapeutics

Frontiers in Pharmacology, 2021
Skeletal muscle undergoes vigorous tissue remodeling after injury. However, aging, chronic inflammatory diseases, sarcopenia, and neuromuscular disorders cause muscle loss and degeneration, resulting in muscular dysfunction.
Yuki Saito, Takako S. Chikenji, Takako S. Chikenji   +2 more
doaj   +1 more source

Astrocytes in Brain Aging and Neurodegeneration: Cellular Mechanisms and Interventional Strategies

Journal of Neurochemistry, Volume 170, Issue 5, May 2026.
Aging disrupts astrocyte physiology and contributes to cognitive decline. We highlight recent evidence showing that senescent astrocytes lose lamin‐B1, develop nuclear abnormalities, display impaired mitochondrial and metabolic function, and provide reduced synaptic support.
Flávia C. A. Gomes, Isadora Matias
wiley   +1 more source

All cells are created equal in the sight of autophagy: selective autophagy maintains homeostasis in senescent cells

, 2021
Macroautophagy/autophagy is a sophisticated quality control program that limits cellular damage and maintains homeostasis, being an essential part of several lifespan-promoting interventions. However, autophagy is also necessary for full establishment of
Kang, Chanhee, Lee, Yeonghyeon, Kim, Mi-Sung, Kim, Jaejin, Jeon, Taerang   +4 more
core   +1 more source

The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice

Nature Communications, 2020
Senotherapy, the removal of aged T cells, is an effective approach to attenuate age-related diseases. Here the authors report a CD153 targeting vaccine that prevents the accumulation of senescent adipose tissue T cells in mice on high-fat diet, which is ...
Shota Yoshida, Hironori Nakagami, Hiroki Hayashi, Yuka Ikeda, Jiao Sun, Akiko Tenma, Hideki Tomioka, Tomohiro Kawano, Munehisa Shimamura, Ryuichi Morishita, Hiromi Rakugi   +10 more
doaj   +1 more source

Integrative Approaches to Treating Cellular Senescence in Kidney Disease

Advanced Science, Volume 13, Issue 21, 13 April 2026.
ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Tomoka Misawa, Amruta A, LaTonya J. Hickson, Joy Wolfram   +3 more
wiley   +1 more source

Morphofunctional Heterogeneity and Plasticity of Glioblastoma Cells Induced to Senescence by Temozolomide

Aging Cell, Volume 25, Issue 4, April 2026.
Glioblastoma cells induced to senescence by Temozolomide are heterogeneous, with the emergence of two main states, named E‐state and F‐state, which differ in cellular morphometry, survival mechanisms, and sensitivity to autophagy modulators and senolytics. These states are dynamic, with the occurrence of morphofunctional transitions.
Solon Andrades da Rosa, Henrique Quaiato de Oliveira, Laura Boose de Mendonça, Nicole Borgmann de Oliveira, Mariane da Cunha Jaeger, Luiza Cherobini Pereira, Fernanda Dittrich Pinto Oliveira, Debora Santos‐Sousa, Fernanda Saez‐Calazans, Luana Lenz, Melike Lakadamyali, Guido Lenz, Eduardo Cremonese Filippi‐Chiela   +12 more
wiley   +1 more source

Modulation of tumor plasticity by senescent cells: Deciphering basic mechanisms and survival pathways to unravel therapeutic options [PDF]

Genetics and Molecular Biology
Senescence is a cellular state in which the cell loses its proliferative capacity, often irreversibly. Physiologically, it occurs due to a limited capacity of cell division associated with telomere shortening, the so-called replicative senescence. It can
Andrew Oliveira Silva, Thais Cardoso Bitencourt, Jose Eduardo Vargas, Lucas Rosa Fraga, Eduardo Filippi-Chiela   +4 more
doaj   +1 more source

Self‐Immolative Systems in Diagnostic and Therapeutic Applications

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
Self‐Immolative Systems enable the precise, residue‐free release of active molecules, drugs, probes, or sensors, via cyclization or elimination, triggered by specific stimuli. Their versatility drives advances in drug delivery, diagnostics, nanotechnology, materials chemistry, and biosensing, offering chemists control over molecular activation and ...
Windbedema Prisca Ouédraogo, Thomas Cailly, Valérie Collot   +2 more
wiley   +1 more source

Human MSC-Derived Exosomes Reduce Cellular Senescence in Renal Epithelial Cells

, 2021
Cellular senescence of renal tubular cells is associated with chronic diseases and age-related kidney disorders. Therapies to antagonize senescence are, therefore, explored as novel approaches in nephropathy.
Ralf Hass, Chieh Ming Liao, Tianjiao Luo, Roland Schmitt, Blanca de Juan Mora, Juliane von der Ohe   +5 more
core   +1 more source