Results 41 to 50 of about 1,649 (193)
Senotherapeutics for HIV and aging
Current Opinion in HIV and AIDS, 2020 Purpose of review To summarize the state of chronic, treated HIV infection and its contribution to accelerated aging, and to evaluate recent research relevant to the study and treatment of aging and senescence. Recent findings Chronic treated HIV-1 infection is associated with ...
Matthew A, Szaniawski, Adam M, Spivak
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Mitochondrial Homeostasis and Cellular Senescence [PDF]
, 2019 Cellular senescence refers to a stress response aiming to preserve cellular and, therefore, organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic mechanisms, manifested as impaired mitochondrial biogenesis, metabolism and ...
Chronopoulos, Efstathios +9 more
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Sexual Dimorphic Metabolic and Cognitive Responses of C57BL/6 Mice to Fisetin or Dasatinib and Quercetin Cocktail Oral Treatment. [PDF]
, 2023 Senolytic treatment in aged mice clears senescent cell burden leading to functional improvements. However, less is known regarding the effects of these compounds when administered prior to significant senescent cell accumulation. From 4-13 months of age,
Bartke, Andrzej +8 more
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Meeting Report: Aging Research and Drug Discovery [PDF]
, 2022 Aging is the single largest risk factor for most chronic diseases, and thus possesses large socioeconomic interest to continuously aging societies. Consequently, the field of aging research is expanding alongside a growing focus from the industry and ...
Ai, Ruixue +77 more
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Frontiers in Pharmacology, 2023 Objective: The field of targeting cellular senescence with drug candidates to address age-related comorbidities has witnessed a notable surge of interest and research and development.
Li Ping Wong +7 more
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Dasatinib Attenuates Fibrosis in Keloids by Decreasing Senescent Cell Burden
Acta Dermato-Venereologica, 2023 Keloids are skin tumours caused by aberrant growth of dermal fibroblasts. Cellular senescence contributes to aging and various pathological conditions, including cancer, atherosclerosis, and fibrotic diseases.
Claudia C. Darmawan +5 more
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Senotherapeutics and Their Molecular Mechanism for Improving Aging
Biomolecules & Therapeutics, 2022 Aging is defined as physiological dysfunction of the body and a key risk factor for human diseases. During the aging process, cellular senescence occurs in response to various extrinsic and intrinsic factors such as radiation-induced DNA damage, the activation of oncogenes, and oxidative stress.
Park, Jooho, Shin, Dong Wook
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Translating Senotherapeutic Interventions into the Clinic with Emerging Proteomic Technologies
Biology, 2023 Cellular senescence is a state of irreversible growth arrest with profound phenotypic changes, including the senescence-associated secretory phenotype (SASP).
Amit K. Dey +7 more
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Senotherapeutic Effect of Retinaldehyde and Hyaluronate Fragments in Dermatoporosis
Dermatopathology, 2023 Cellular senescence is one of the important mechanisms of skin aging. In a recent study, we have shown that in patients with dermatoporosis, an extreme senescence condition of the skin, cells positive for p16Ink4a, a biomarker of senescence, were significantly increased in the epidermis.
Kaya, Aysin +2 more
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Moving from an “anti-aging” paradigm toward the concept of “disease-free aging”: the role of senolytics in modern medicine [PDF]
Geriatrics, Gerontology and AgingSenescent cells increase with aging and are related to the promotion of inflammation and neoplasia through the senescence-associated secretory phenotype (SASP). These cells are closely related to the biological aging process and, most importantly, to age-
Ivan Aprahamian +2 more
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