Results 41 to 50 of about 1,366 (168)
Targeting cellular senescence with senotherapeutics: senolytics and senomorphics [PDF]
The FEBS Journal, 2022 The concept of geroscience is that since ageing is the greatest risk factor for many diseases and conditions, targeting the ageing process itself will have the greatest impact on human health. Of the hallmarks of ageing, cellular senescence has emerged as a druggable therapeutic target for extending healthspan in model organisms. Cellular senescence is
Lei Zhang +4 more
openaire +2 more sources
Senotherapeutics in Malignant Brain Cancer Therapy. [PDF]
Curr Oncol RepAbstract Purpose of Review Malignant brain cancer, the most severe form is glioblastoma (GBM), has a dismal prognosis, despite maximal resection followed by radio-chemotherapy. First line therapeutics are alkylating drugs, notably the DNA-methylating temozolomide (TMZ), administered ...
Kaina B, Christmann M.
europepmc +4 more sources
Frontiers in Pharmacology, 2023 Objective: The field of targeting cellular senescence with drug candidates to address age-related comorbidities has witnessed a notable surge of interest and research and development.
Li Ping Wong +7 more
doaj +1 more source
Dasatinib Attenuates Fibrosis in Keloids by Decreasing Senescent Cell Burden
Acta Dermato-Venereologica, 2023 Keloids are skin tumours caused by aberrant growth of dermal fibroblasts. Cellular senescence contributes to aging and various pathological conditions, including cancer, atherosclerosis, and fibrotic diseases.
Claudia C. Darmawan +5 more
doaj +1 more source
Senotherapeutics and Their Molecular Mechanism for Improving Aging
Biomolecules & Therapeutics, 2022 Aging is defined as physiological dysfunction of the body and a key risk factor for human diseases. During the aging process, cellular senescence occurs in response to various extrinsic and intrinsic factors such as radiation-induced DNA damage, the activation of oncogenes, and oxidative stress.
Park, Jooho, Shin, Dong Wook
openaire +2 more sources
Senotherapeutic Effect of Retinaldehyde and Hyaluronate Fragments in Dermatoporosis
Dermatopathology, 2023 Cellular senescence is one of the important mechanisms of skin aging. In a recent study, we have shown that in patients with dermatoporosis, an extreme senescence condition of the skin, cells positive for p16Ink4a, a biomarker of senescence, were significantly increased in the epidermis.
Kaya, Aysin +2 more
openaire +4 more sources
Moving from an “anti-aging” paradigm toward the concept of “disease-free aging”: the role of senolytics in modern medicine [PDF]
Geriatrics, Gerontology and AgingSenescent cells increase with aging and are related to the promotion of inflammation and neoplasia through the senescence-associated secretory phenotype (SASP). These cells are closely related to the biological aging process and, most importantly, to age-
Ivan Aprahamian +2 more
doaj +1 more source
Fisetin is a senotherapeutic that extends health and lifespan [PDF]
EBioMedicine, 2018 Senescence is a tumor suppressor mechanism activated in stressed cells to prevent replication of damaged DNA. Senescent cells have been demonstrated to play a causal role in driving aging and age-related diseases using genetic and pharmacologic approaches.
Yousefzadeh, Matthew J. +21 more
openaire +2 more sources
From genoprotection to rejuvenation
Frontiers in Bioscience-Landmark, 2020 Aging results from aberrations in signaling mechanisms and decline in biologic activities and cellular functions. Anti-aging strategies include a number of dietary, genetic, and pharmacological interventions that converge on a core network of nutrient ...
Siamak Tabibzadeh
doaj +1 more source
Frontiers in Endocrinology, 2023 Recent advances in aging research have provided novel insights for the development of senotherapy, which utilizes cellular senescence as a therapeutic target.
Sachi Matsubayashi +3 more
doaj +1 more source