Results 21 to 30 of about 416 (129)
Regulation of Cellular Senescence in Type 2 Diabetes Mellitus: From Mechanisms to Clinical Applications [PDF]
Diabetes & Metabolism Journal, 2023 Cellular senescence is accelerated by hyperglycemia through multiple pathways. Therefore, senescence is an important cellular mechanism to consider in the pathophysiology of type 2 diabetes mellitus (T2DM) and an additional therapeutic target. The use of
Kanako Iwasaki +2 more
doaj +1 more source
Idiopathic pulmonary fibrosis - novel approach on future treatment
Journal of Education, Health and Sport, 2023 Introduction Idiopathic pulmonary fibrosis (IPF) is a fatal pulmonary disease that leads to progressive fibrosis and extremely poor resaults.. Since the etiology is unknown, there are highly limited options of the IPF treatment.
Katarzyna Pacek +7 more
doaj +1 more source
Senotherapeutics: Milestones, innovations, and future prospects
Gerontological practice has evolved over the decades in response to various diseases, comorbidities, and demographic factors. The many subfields that have emerged from our advancement include the study of biomedical gerontology. Geropharmacology, which began to be recognized as a distinct subfield in the latter part of the 20th century, is the study of
Atasever, Erdem +2 more
openaire +3 more sources
, 2021 Several investigations on senescence and its causative role in aging have underscored the importance of developing senotherapeutics, a field focused on killing senescent cells and/or preventing their accumulation within tissues.
Squillaro T. +7 more
core +2 more sources
Skin aging from mechanisms to interventions: focusing on dermal aging
Frontiers in Physiology, 2023 Skin aging is a multifaceted process that involves intrinsic and extrinsic mechanisms that lead to various structural and physiological changes in the skin.
Sun Hye Shin +3 more
doaj +1 more source
Aging and oral squamous cell carcinoma development: the role of cellular senescence
Frontiers in Oral Health, 2023 The gradual accumulation and inadequate renewal of senescent cells over time drive organismal aging. Senescent cells undergo altered gene expression and release inflammatory mediators collectively termed the senescence-associated secretory phenotype ...
Sven Eric Niklander +3 more
doaj +1 more source
Biomolecules, 2023 Background: Low back pain is a global health problem directly related to intervertebral disc (IVD) degeneration. Senolytic drugs (RG-7112 and o-Vanillin) target and remove senescent cells from IVDs in vitro, improving tissue homeostasis.
Matthew Mannarino +8 more
doaj +1 more source
Cellular senescence: a key therapeutic target in aging and diseases
The Journal of Clinical Investigation, 2022 Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in response to cellular damage and stress. Senescent cells (SnCs) can develop a characteristic pathogenic senescence-associated secretory phenotype (SASP) that drives ...
Lei Zhang +5 more
doaj +1 more source
The Emergence of Senescent Surface Biomarkers as Senotherapeutic Targets [PDF]
Cells, 2021 Senescence is linked to a wide range of age-associated diseases and physiological declines. Thus, senotherapeutics are emerging to suppress the detrimental effects of senescence either by senomorphics or senolytics. Senomorphics suppress the traits associated with senescence phenotypes, while senolytics aim to clear senescent cells by suppressing their
Martina Rossi, Kotb Abdelmohsen
openaire +3 more sources
Frontiers in Pharmacology, 2023 Objective: The field of targeting cellular senescence with drug candidates to address age-related comorbidities has witnessed a notable surge of interest and research and development.
Li Ping Wong +7 more
doaj +1 more source