Cellular senescence, neuroinflammation, and microRNAs: Possible interactions driving aging and neurodegeneration in the hippocampal neurogenic niche. [PDF]
Aging BrainCellular senescence influences normal physiology and ageing-related diseases, including neurodegeneration. Senescent cells accumulate with age in the brain, secreting pro-inflammatory factors that promote neuroinflammation, which has been linked to ...
Polzer O, Kinloch E, Fitzsimons CP.
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The promise of organ rejuvenation to overcome the shortage in organ transplantation [PDF]
Nature CommunicationsOrgan shortage remains a major barrier in treating end-stage organ failure, with many patients dying while waiting or becoming medically unfit by the time an organ is offered.
Mukhammad Kayumov +6 more
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Terpenes: natural compounds found in plants as potential senotherapeutics targeting senescent mesenchymal stromal cells and promoting apoptosis [PDF]
Stem Cell Research & TherapyBackground Senescence in stem cells and progenitor cells can be particularly detrimental because these cells are essential for tissue renewal and overall organismal homeostasis.
Valeria Mazzone +7 more
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The potential for senotherapy as a novel approach to extend life quality in veterinary medicine [PDF]
Frontiers in Veterinary ScienceCellular senescence, a condition where cells undergo arrest and can assume an inflammatory phenotype, has been associated with initiation and perpetuation of inflammation driving multiple disease processes in rodent models and humans.
Zoë J. Williams +4 more
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The Emergence of Senescent Surface Biomarkers as Senotherapeutic Targets [PDF]
Cells, 2021 Senescence is linked to a wide range of age-associated diseases and physiological declines. Thus, senotherapeutics are emerging to suppress the detrimental effects of senescence either by senomorphics or senolytics.
Martina Rossi, Kotb Abdelmohsen
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Upregulation of senescence-associated gene expression levels in human gingival tissue affected by periodontitis. [PDF]
J PeriodontolBackground: Accumulation of senescent cells is increasingly recognized as a mechanism of aging and is considered an attractive therapeutic target for various age-associated diseases.
Kim SJ +7 more
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Frontiers in GeneticsVascular diseases pose major health challenges, and understanding their underlying molecular mechanisms is essential to advance therapeutic interventions. Cellular senescence, a hallmark of aging, is a cellular state characterized by cell-cycle arrest, a
Oscar Fraile-Martinez +31 more
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Integrative Approaches to Treating Cellular Senescence in Kidney Disease. [PDF]
Adv Sci (Weinh)ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Misawa T, A A, Hickson LJ, Wolfram J.
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Assessment of Pullulan, a Microbial Polysaccharide, as a Matrix for Senotherapeutics Delivery
Chemistry Proceedings, 2023 This study’s objective was to assess pullulan, in the form of pullulan acetate, as a matrix for senotherapeutics delivery. Polymeric nanoparticles loaded with various senotherapeutics (metformin, quercitin, kaempferol, curcumin, and luteolin) were ...
Ramona-Daniela Pavaloiu +4 more
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Frontiers in Nutrition, 2022 Aging is a natural physiological process, but one that poses major challenges in an increasingly aging society prone to greater health risks such as diabetes, cardiovascular disease, cancer, frailty, increased susceptibility to infection, and reduced ...
Carla Luís +13 more
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