Results 21 to 30 of about 1,366 (168)
Senescent Cells: A Therapeutic Target in Cardiovascular Diseases
Cells, 2023 Senescent cell accumulation has been observed in age-associated diseases including cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence-associated secretory phenotype (SASP) factors that may cause or worsen many ...
Masayoshi Suda +7 more
doaj +2 more sources
Senotherapeutics for HIV and aging
Current Opinion in HIV and AIDS, 2020 Purpose of review To summarize the state of chronic, treated HIV infection and its contribution to accelerated aging, and to evaluate recent research relevant to the study and treatment of aging and senescence. Recent findings Chronic treated HIV-1 infection is associated with ...
Matthew A, Szaniawski, Adam M, Spivak
openaire +4 more sources
Senotherapeutics: Different approaches of discovery and development
Molecules and CellsJee Hyeon Yoon, Ho Jae Han
exaly +5 more sources
Proteomic and Biological Analysis of the Effects of Metformin Senomorphics on the Mesenchymal Stromal Cells [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 Senotherapeutics are new drugs that can modulate senescence phenomena within tissues and reduce the onset of age-related pathologies. Senotherapeutics are divided into senolytics and senomorphics.
Mustafa Burak Acar +10 more
doaj +4 more sources
Hallmarks and Biomarkers of Skin Senescence: An Updated Review of Skin Senotherapeutics [PDF]
Antioxidants, 2023 Aging is a complex process characterized by an ongoing decline in physiological functions, leading to degenerative diseases and an increased probability of death. Cellular senescence has been typically considered as an anti-proliferative process; however,
Darya Bulbiankova +5 more
doaj +2 more sources
Translating Senotherapeutic Interventions into the Clinic with Emerging Proteomic Technologies
Biology, 2023 Cellular senescence is a state of irreversible growth arrest with profound phenotypic changes, including the senescence-associated secretory phenotype (SASP).
Amit K. Dey +7 more
doaj +2 more sources
Biomedicines, 2023 Background: Knee osteoarthritis (KOA) is one of the most common causes of disability in elderly patients and tends to be a major burden on social and health care spending.
Andrea Bernetti +6 more
doaj +2 more sources
The promise of organ rejuvenation to overcome the shortage in organ transplantation [PDF]
Nature CommunicationsOrgan shortage remains a major barrier in treating end-stage organ failure, with many patients dying while waiting or becoming medically unfit by the time an organ is offered.
Mukhammad Kayumov +6 more
doaj +2 more sources
The Emergence of Senescent Surface Biomarkers as Senotherapeutic Targets [PDF]
Cells, 2021 Senescence is linked to a wide range of age-associated diseases and physiological declines. Thus, senotherapeutics are emerging to suppress the detrimental effects of senescence either by senomorphics or senolytics.
Martina Rossi, Kotb Abdelmohsen
doaj +3 more sources
MetabolitesChronic low back pain, a major cause of disability with a great global socioeconomic impact, has been inextricably associated with intervertebral disc degeneration.
Eleni Mavrogonatou, Dimitris Kletsas
doaj +2 more sources