Results 11 to 20 of about 1,649 (193)
Senotherapeutics in Cancer and HIV
Cells, 2022 Cellular senescence is a stress-response mechanism that contributes to homeostasis maintenance, playing a beneficial role during embryogenesis and in normal adult organisms.
José R Blanco, Amancio Carnero
exaly +7 more sources
The costs and benefits of senotherapeutics for human health [PDF]
The Lancet. Healthy Longevity, 2022 Summary: Cellular senescence is a major contributor to age-related diseases in humans; however, it also has a beneficial role in physiological and pathological processes, including wound healing, host immunity, and tumour suppression. Reducing the burden
Marco Raffaele, PhD +1 more
doaj +6 more sources
Aging and Senotherapeutics [PDF]
Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti, 2019 One of the key mechanisms of the aging process of an organism and of the dysfunctionality and chronic diseases related with aging is the so-called cell senescence.
Ivana Čepelak, Slavica Dodig
core +4 more sources
Senotherapeutics: Different approaches of discovery and development
Molecules and CellsJee Hyeon Yoon, Ho Jae Han
exaly +5 more sources
Senescence Modulation: An Applied Science Review of Strategies in Anti-Aging, Regenerative Aesthetics, and Oncology Therapy [PDF]
Current Issues in Molecular BiologyCellular senescence is an irreversible cell cycle arrest, triggered by stressors like telomere shortening, DNA damage, and oncogenic signaling. These cells, often referred to as ‘zombie cells’ because they cease dividing yet resist apoptosis, drive the ...
Steven Januar Kusmanto
doaj +2 more sources
Network Pharmacology and Machine Learning Identify Flavonoids as Potential Senotherapeutics [PDF]
PharmaceuticalsBackground/Objectives: Cellular senescence is characterised by irreversible cell cycle arrest and the secretion of a proinflammatory phenotype. In recent years, senescent cell accumulation and senescence-associated secretory phenotype (SASP) secretion ...
Jose Alberto Santiago-de-la-Cruz +3 more
doaj +2 more sources
Cells, 2020 The higher death rate caused by COVID-19 in older people, especially those with comorbidities, is a challenge for biomedical aging research. Here we explore the idea that an exacerbated inflammatory response, in particular that mediated by IL-6, may ...
Marco Malavolta +2 more
exaly +3 more sources
Cellular Senescence in Health, Disease, and Lens Aging [PDF]
PharmaceuticalsBackground: Cellular senescence is a state of irreversible cell cycle arrest that serves as a critical regulator of tissue homeostasis, aging, and disease.
Ying Qin, Haoxin Liu, Hongli Wu
doaj +2 more sources
Role of Cellular Senescence in Parkinson’s Disease: Potential for Disease-Modification Through Senotherapy [PDF]
BiomedicinesParkinson’s disease (PD) is an aging-related neurodegenerative disease characterized by a progressive loss of dopamine (DA)-secreting neurons in the substantia nigra. Most of the currently available treatments attempt to alleviate the disease symptoms by
David J. Rademacher +2 more
doaj +2 more sources
Senescent cells as a target for anti-aging interventions: From senolytics to immune therapies. [PDF]
J Transl Int MedAging and age-related diseases are major drivers of multimorbidity and mortality worldwide. Cellular senescence is a hallmark of aging. The accumulation of senescent cells is causally associated with pathogenesis of various age-associated disorders.
Fu TE, Zhou Z.
europepmc +3 more sources