Results 11 to 20 of about 416 (129)

Senotherapeutics for HIV and aging

Current Opinion in HIV and AIDS, 2020
Purpose of review To summarize the state of chronic, treated HIV infection and its contribution to accelerated aging, and to evaluate recent research relevant to the study and treatment of aging and senescence. Recent findings Chronic treated HIV-1 infection is associated with ...
Matthew A, Szaniawski, Adam M, Spivak
openaire   +4 more sources

Exploring the Relevance of Senotherapeutics for the Current SARS-CoV-2 Emergency and Similar Future Global Health Threats [PDF]

Cells, 2020
The higher death rate caused by COVID-19 in older people, especially those with comorbidities, is a challenge for biomedical aging research. Here we explore the idea that an exacerbated inflammatory response, in particular that mediated by IL-6, may ...
Marco Malavolta, Robertina Giacconi, Dario Brunetti, Mauro Provinciali, Fabrizio Maggi   +4 more
doaj   +2 more sources

Senotherapeutics: Different approaches of discovery and development

Molecules and Cells
Ho Jae Han, Jee Hyeon Yoon
exaly   +5 more sources

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
openaire   +2 more sources

Targeting cellular senescence through nutritional senotherapeutics in brain aging and neurodegenerative diseases

Frontiers in Nutrition
Cellular senescence has emerged as a key contributor to brain aging and neurodegenerative diseases, which are increasing in prevalence as life expectancy rises.
Verónica Salas-Venegas, Norma E. López-Diazguerrero, Ricardo J. Ramírez-Carreto, Ricardo J. Ramírez-Carreto, Mina Konigsberg, Anahí Chavarría   +5 more
doaj   +2 more sources

Targeting Senescence in Oncology: An Emerging Therapeutic Avenue for Cancer

Current Oncology
Since cancer is often linked to the aging process, the importance of cellular senescence in cancer has come under the spotlight. While senescence in cancer cells can serve as a natural barrier against cancer due to its proliferation arrest, its secretory
Satoru Meguro, Syunta Makabe, Kei Yaginuma, Akifumi Onagi, Ryo Tanji, Kanako Matsuoka, Seiji Hoshi, Tomoyuki Koguchi, Emina Kayama, Junya Hata, Yuichi Sato, Hidenori Akaihata, Masao Kataoka, Soichiro Ogawa, Motohide Uemura, Yoshiyuki Kojima   +15 more
doaj   +2 more sources

Network Pharmacology and Machine Learning Identify Flavonoids as Potential Senotherapeutics

Pharmaceuticals
Background/Objectives: Cellular senescence is characterised by irreversible cell cycle arrest and the secretion of a proinflammatory phenotype. In recent years, senescent cell accumulation and senescence-associated secretory phenotype (SASP) secretion ...
Jose Alberto Santiago-de-la-Cruz, Nadia Alejandra Rivero-Segura, María Elizbeth Alvarez-Sánchez, Juan Carlos Gomez-Verjan   +3 more
doaj   +2 more sources

Role of Cellular Senescence in Parkinson’s Disease: Potential for Disease-Modification Through Senotherapy

Biomedicines
Parkinson’s disease (PD) is an aging-related neurodegenerative disease characterized by a progressive loss of dopamine (DA)-secreting neurons in the substantia nigra. Most of the currently available treatments attempt to alleviate the disease symptoms by
David J. Rademacher, Jacob E. Exline, Eileen M. Foecking   +2 more
doaj   +2 more sources

Terpenes: natural compounds found in plants as potential senotherapeutics targeting senescent mesenchymal stromal cells and promoting apoptosis

Stem Cell Research & Therapy
Background Senescence in stem cells and progenitor cells can be particularly detrimental because these cells are essential for tissue renewal and overall organismal homeostasis.
Valeria Mazzone, Nicola Alessio, Domenico Aprile, Giovanni Galano, Roberto De Rosa, Chiara Schiraldi, Giovanni Di Bernardo, Umberto Galderisi   +7 more
doaj   +2 more sources

IL-1 and senescence: Friends and foe of EGFR neutralization and immunotherapy

Frontiers in Cell and Developmental Biology, 2023
Historically, senescence has been considered a safe program in response to multiple stresses in which cells undergo irreversible growth arrest. This process is characterized by morphological and metabolic changes, heterochromatin formation, and secretion
Donatella Romaniello, Donatella Romaniello, Valerio Gelfo, Valerio Gelfo, Federica Pagano, Michela Sgarzi, Alessandra Morselli, Cinzia Girone, Daria Maria Filippini, Daria Maria Filippini, Gabriele D’Uva, Gabriele D’Uva, Gabriele D’Uva, Mattia Lauriola, Mattia Lauriola   +14 more
doaj   +1 more source