Results 11 to 20 of about 1,366 (168)
Senotherapeutics in Cancer and HIV
Cells, 2022 Cellular senescence is a stress-response mechanism that contributes to homeostasis maintenance, playing a beneficial role during embryogenesis and in normal adult organisms.
Laura Sánchez-Díaz +3 more
doaj +6 more sources
Senotherapeutics for metabolic disease and diabetic complications [PDF]
Journal of Internal MedicineAbstract Metabolic diseases, including obesity, Type 2 diabetes (T2D), and metabolic syndrome, are increasingly prevalent worldwide, driven by sedentary lifestyles, aging populations, and complex genetic and environmental factors. Traditionally understood as disorders of glucose and lipid metabolism, a growing body of evidence now ...
Allyson K Palmer +2 more
exaly +6 more sources
The costs and benefits of senotherapeutics for human health [PDF]
The Lancet. Healthy Longevity, 2022 Summary: Cellular senescence is a major contributor to age-related diseases in humans; however, it also has a beneficial role in physiological and pathological processes, including wound healing, host immunity, and tumour suppression. Reducing the burden
Marco Raffaele, PhD +1 more
doaj +6 more sources
Exploring the Relevance of Senotherapeutics for the Current SARS-CoV-2 Emergency and Similar Future Global Health Threats [PDF]
Cells, 2020 The higher death rate caused by COVID-19 in older people, especially those with comorbidities, is a challenge for biomedical aging research. Here we explore the idea that an exacerbated inflammatory response, in particular that mediated by IL-6, may ...
Marco Malavolta +2 more
exaly +4 more sources
Terpenes: natural compounds found in plants as potential senotherapeutics targeting senescent mesenchymal stromal cells and promoting apoptosis [PDF]
Stem Cell Research & TherapyBackground Senescence in stem cells and progenitor cells can be particularly detrimental because these cells are essential for tissue renewal and overall organismal homeostasis.
Valeria Mazzone +7 more
doaj +3 more sources
Role of Cellular Senescence in Parkinson’s Disease: Potential for Disease-Modification Through Senotherapy [PDF]
BiomedicinesParkinson’s disease (PD) is an aging-related neurodegenerative disease characterized by a progressive loss of dopamine (DA)-secreting neurons in the substantia nigra. Most of the currently available treatments attempt to alleviate the disease symptoms by
David J. Rademacher +2 more
doaj +3 more sources
Cellular Senescence in Health, Disease, and Lens Aging [PDF]
PharmaceuticalsBackground: Cellular senescence is a state of irreversible cell cycle arrest that serves as a critical regulator of tissue homeostasis, aging, and disease.
Ying Qin, Haoxin Liu, Hongli Wu
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Assessment of Pullulan, a Microbial Polysaccharide, as a Matrix for Senotherapeutics Delivery
Chemistry Proceedings, 2023 This study’s objective was to assess pullulan, in the form of pullulan acetate, as a matrix for senotherapeutics delivery. Polymeric nanoparticles loaded with various senotherapeutics (metformin, quercitin, kaempferol, curcumin, and luteolin) were ...
Ramona-Daniela Pavaloiu +4 more
doaj +2 more sources
Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti, 2019 One of the key mechanisms of the aging process of an organism and of the dysfunctionality and chronic diseases related with aging is the so-called cell senescence. It implies irreversible cell cycle arrest that occurs in response to different forms of cellular stress.
Čepelak, Ivana, Dodig, Slavica
openaire +4 more sources
Frontiers in Nutrition, 2022 Aging is a natural physiological process, but one that poses major challenges in an increasingly aging society prone to greater health risks such as diabetes, cardiovascular disease, cancer, frailty, increased susceptibility to infection, and reduced ...
Carla Luís +13 more
doaj +2 more sources