Results 131 to 140 of about 1,366 (168)

Cellular senescence in lung cancer immune microenvironment and senotherapeutic opportunities. [PDF]

iScience
Xu Z, Liu F, Huang S, Chu Q.
europepmc   +1 more source

Targeting cellular senescence in progenitor cells as a strategy to enhance bone regeneration by cell therapies: a systematic review of pre-clinical investigations. [PDF]

Stem Cell Res Ther
Morita M, Damle EB, Shinohara I, Murayama M, Susuki Y, Gao Q, Ma C, Chow SK, Goodman SB.   +8 more
europepmc   +1 more source

Identification of a novel target for senotherapeutics in fibroblasts

, 2018
AN, SUGYUN, Kang, Junsoo, Lee, Soobeom, Cho, Kwang-Hyun   +3 more
core  

Senotherapeutics for healthy ageing [PDF]

Nature Reviews Drug Discovery, 2018
Laura J Niedernhofer, Paul D Robbins, Robbins Paul D   +2 more
exaly   +4 more sources

Senescence and senotherapeutics: a new field in cancer therapy

Pharmacology & Therapeutics, 2019
Cellular senescence is a stress response mechanism ensuring homeostasis. Its temporal activation during embryonic development or normal adult life is linked with beneficial properties. In contrast, persistent (chronic) senescence seems to exert detrimental effects fostering aging and age-related disorders, such as cancer.
Vassilios Myrianthopoulos, Konstantinos Evangelou, Tomer Cooks   +2 more
exaly   +7 more sources

Senotherapeutics: Experimental therapy of cellular senescence

, 2021
Jamie N Justice, Laura J Niedernhofer, Miranda E Orr   +2 more
exaly   +3 more sources

Biomolecular Evaluation of Piceatannol’s Effects in Counteracting the Senescence of Mesenchymal Stromal Cells: A New Candidate for Senotherapeutics?

International Journal of Molecular Sciences, 2021
Several investigations on senescence and its causative role in aging have underscored the importance of developing senotherapeutics, a field focused on killing senescent cells and/or preventing their accumulation within tissues.
Nicola Alessio, Tiziana Squillaro, Roberto De Rosa   +2 more
exaly   +3 more sources

Senescence in HBV-, HCV- and NAFLD- Mediated Hepatocellular Carcinoma and Senotherapeutics: Current Evidence and Future Perspective

Cancers, 2021
Simple Summary Recent scientific discoveries identify cell senescence as pivotal in hepatocellular cancer (HCC) biology. Specifically, hepatitis B virus (HBV), hepatitis C virus (HCV) and non-alcoholic fatty liver disease (NAFLD) are major risk factors ...
Peter Dubovan, Eleni Papoutsi, John Koskinas   +2 more
exaly   +3 more sources

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Osteoarthritis in time for senotherapeutics

Joint Bone Spine, 2021
Christian Jörgensen, Jean-Marc Brondello   +1 more
exaly   +3 more sources

Recent Advances in Senotherapeutics Delivery

Tissue Engineering - Part B: Reviews, 2022
Accumulation of senescent cells (SnCs) in various tissue types has been connected to an occurrence of different age-related diseases that are indicated by its own tissue-specific hallmarks. Discovery of novel senolytic compounds that target major cellular mechanisms to inhibit the level of SnCs within the specific tissues or organs
Ji Young Choi, Guang Yang, John P Fisher   +2 more
exaly   +3 more sources