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Senotherapeutics for healthy ageing [PDF]
Nature Reviews Drug Discovery, 2018 Laura J Niedernhofer
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Mitochondria-targeted senotherapeutic interventions
Biogerontology, 2022Healthy aging is the art of balancing a delicate scale. On one side of the scale, there are the factors that make life difficult with aging, and on the other side are the products of human effort against these factors. The most important factors that make the life difficult with aging are age-related disorders. Developing senotherapeutic strategies may
Mehmet Can Atayik, Ufuk Çakatay
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Senotherapeutics and HIV-1 Persistence
Current HIV/AIDS Reports, 2020To review the potential use of senotherapeutics, pharmacologic agents that target senescent cells, in addressing HIV-1 persistence.Treated HIV-1 infection results in a state of immune exhaustion, which may involve reprogramming of infected and bystander cells toward a state of cellular senescence.
Matthew A Szaniawski, Adam M Spivak
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Recent Advances in Senotherapeutics Delivery
Tissue Engineering - Part B: Reviews, 2022Accumulation of senescent cells (SnCs) in various tissue types has been connected to an occurrence of different age-related diseases that are indicated by its own tissue-specific hallmarks. Discovery of novel senolytic compounds that target major cellular mechanisms to inhibit the level of SnCs within the specific tissues or organs has been an emerging
Ji Young Choi, Guang Yang
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Osteoarthritis in time for senotherapeutics
Joint Bone Spine, 2021Christian Jorgensen, Jean-Marc Brondello
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Senotherapeutics for mesenchymal stem cell senescence and rejuvenation
Drug Discovery Today, 2023Mesenchymal stem cells (MSCs) are susceptible to replicative senescence and senescence-associated functional decline, which hampers their use in regenerative medicine. Senotherapeutics are drugs that target cellular senescence through senolytic and senomorphic functions to induce apoptosis and suppress chronic inflammation caused by the senescence ...
Thamil Selvee Ramasamy
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Nanocarriers for natural polyphenol senotherapeutics
Aging CellAbstractSenescence is a heterogenous and dynamic process in which various cell types undergo cell‐cycle arrest due to cellular stressors. While senescence has been implicated in aging and many human pathologies, therapeutic interventions remain inadequate due to the absence of a comprehensive set of biomarkers in a context‐dependent manner. Polyphenols
Natali Joma +2 more
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Cellular Senescence in Human Skin Aging: Leveraging Senotherapeutics
Gerontology, 2023Background: As the largest organ in the human body, the skin is continuously exposed to intrinsic and extrinsic stimuli that impact its functionality and morphology with aging. Skin aging entails dysregulation of skin cells and loss, fragmentation, or fragility of extracellular matrix fibers that are manifested macroscopically by wrinkling, laxity, and
Saranya P, Wyles +7 more
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Senescence and senotherapeutics: a new field in cancer therapy
Pharmacology & Therapeutics, 2019 Cellular senescence is a stress response mechanism ensuring homeostasis. Its temporal activation during embryonic development or normal adult life is linked with beneficial properties. In contrast, persistent (chronic) senescence seems to exert detrimental effects fostering aging and age-related disorders, such as cancer.
Vassilios Myrianthopoulos +2 more
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