Results 141 to 150 of about 1,366 (168)
Some of the next articles are maybe not open access.
Senotherapeutics and HIV-1 Persistence
Current HIV/AIDS Reports, 2020To review the potential use of senotherapeutics, pharmacologic agents that target senescent cells, in addressing HIV-1 persistence.Treated HIV-1 infection results in a state of immune exhaustion, which may involve reprogramming of infected and bystander cells toward a state of cellular senescence.
Matthew A Szaniawski +2 more
exaly +3 more sources
Mitochondria-targeted senotherapeutic interventions
Biogerontology, 2022Healthy aging is the art of balancing a delicate scale. On one side of the scale, there are the factors that make life difficult with aging, and on the other side are the products of human effort against these factors. The most important factors that make the life difficult with aging are age-related disorders. Developing senotherapeutic strategies may
Mehmet Can Atayik, Ufuk Çakatay
openaire +3 more sources
Senotherapeutics for mesenchymal stem cell senescence and rejuvenation
Drug Discovery Today, 2023Mesenchymal stem cells (MSCs) are susceptible to replicative senescence and senescence-associated functional decline, which hampers their use in regenerative medicine. Senotherapeutics are drugs that target cellular senescence through senolytic and senomorphic functions to induce apoptosis and suppress chronic inflammation caused by the senescence ...
Thamil Selvee Ramasamy
exaly +4 more sources
Targeting the microbiota-mitochondria crosstalk in neurodegeneration with senotherapeutics
Advances in Protein Chemistry and Structural Biology, 2023Neurodegenerative diseases are a group of age-related disorders characterized by a chronic and progressive loss of function and/or structure of synapses, neurons, and glial cells. The etiopathogenesis of neurodegenerative diseases is characterized by a complex network of intricately intertwined pathophysiological processes that are still not fully ...
Jan Homolák
exaly +3 more sources
Cellular parabioisis as a senotherapeutic approach
Beyond cell death and differentiation, cell senescence is profoundly influenced by the social nature of cells, which is intricately linked to cell communication as a fundamental aspect of biological systems shaping both individual and collective cellular behaviors.Sencan, Sevide, Onaran, Ilhan
openaire +2 more sources
Senotherapeutics: Milestones, innovations, and future prospects
Gerontological practice has evolved over the decades in response to various diseases, comorbidities, and demographic factors. The many subfields that have emerged from our advancement include the study of biomedical gerontology. Geropharmacology, which began to be recognized as a distinct subfield in the latter part of the 20th century, is the study ofAtasever, Erdem +2 more
openaire +2 more sources
Stem cell-derived extracellular vesicles as senotherapeutics
Ageing Research ReviewsCellular senescence (CS) is recognized as one of the hallmarks of aging, and an important player in a variety of age-related pathologies. Accumulation of senescent cells can promote a pro-inflammatory and pro-cancerogenic microenvironment. Among potential senotherapeutics are extracellular vesicles (EVs) (40-1000 nm), including exosomes (40-150 nm ...
Ekaterina, Rudnitsky +6 more
openaire +2 more sources
Revolutionizing cancer treatment with senotherapeutics: a current perspective
Cancer Chemotherapy and PharmacologyCellular senescence is a double-edged sword in cancer biology, initially acting as a tumor-suppressive mechanism but later contributing to cancer progression and therapy resistance. Senescent cells, characterized by stable cell cycle arrest, secrete a complex array of bioactive molecules known as the senescence-associated secretory phenotype (SASP ...
Lakshika Singh +5 more
openaire +2 more sources
Senotherapeutic approach to age-related endocrine diseases
Senescent cells progressively accumulate in the endocrine glands and their target tissue during the biological aging process. Senescence leads to hormonal imbalances contributing to various age-related endocrine diseases (AREDs). Cellular senescence, characterized by irreversible cell-cycle arrest, becomes more prevalent in advanced age, and the ...Turgut, Seydanur, Andican, Gülnur
openaire +3 more sources