Results 131 to 140 of about 1,171 (158)

Immunoregulatory mechanisms in the aging microenvironment: Targeting the senescence-associated secretory phenotype for cancer immunotherapy. [PDF]

Acta Pharm Sin B
Wang H, Yu Y, Li R, Zhang H, Chen ZS, Sun C, Zhuang J.   +6 more
europepmc   +1 more source

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Emerging use of senolytics and senomorphics against aging and chronic diseases

Medicinal Research Reviews, 2020
AbstractSenescence is a state of cell cycle arrest that plays an important role in embryogenesis, wound healing and protection against cancer. Senescent cells also accumulate during aging and contribute to the development of age‐related disorders and chronic diseases, such as atherosclerosis, type 2 diabetes, osteoarthritis, idiopathic pulmonary ...
Jan Martel, David M Ojcius, Cheng-Yeu Wu
exaly   +5 more sources

Exploring the fuzzy border between senolytics and senomorphics with chemoinformatics and systems pharmacology

Biogerontology, 2022
Senescent cells accumulate within tissues during aging and secrete an array of pro-inflammatory molecules known as senescent-associated secretory phenotype (SASP), which contribute to the appearance and progression of various chronic degenerative diseases.
Mina Königsberg, Humberto Gutierrez, Jaime Pérez-Villanueva   +2 more
exaly   +3 more sources

Senolytics and senomorphics: Natural and synthetic therapeutics in the treatment of aging and chronic diseases

Free Radical Biology and Medicine, 2021
Cellular senescence is a heterogeneous process guided by genetic, epigenetic and environmental factors, characterizing many types of somatic cells. It has been suggested as an aging hallmark that is believed to contribute to aging and chronic diseases.
Niki Chondrogianni
exaly   +3 more sources

Senomorphic properties of miR-181b in aged human aortic smooth muscle cells

Physiology, 2023
Introduction: Age associated large artery stiffness (LAS) is an independent predictor of adverse cardiovascular health outcomes in humans and has also been shown to be associated with the development of heart failure, kidney disease, and even dementia.
Denisse Moreno, Venkateswara Gogulamudi, Lisa Lesniewski, Steven An, Anthony Donato, Eric Tuday   +5 more
openaire   +1 more source

Senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunction

2023
The accumulation of senescent cells in the aging individual is associated with an increase in the occurrence of age-associated pathologies that contribute to poor health, frailty, and mortality. The number and type of senescent cells is viewed as a contributor to the body's senescence burden.
openaire   +2 more sources

Natural Products Acting as Senolytics and Senomorphics Alleviate Cardiovascular Diseases by Targeting Senescent Cells

Targets
Taken together, cardiovascular diseases (CVDs) have become one of the prime causes of the global disease burden. Aging is closely related to CVDs and is considered to be one of the crucial factors in the incidence of CVDs. In the process of aging, cellular senescence is an important cause of CVDs such as atherosclerosis and atrial fibrillation.
Peng An, Junjie Luo, Peng-Jie Wang
exaly   +2 more sources

Senomorphic, senolytic, and rejuvenation therapies

2022
Xiang Yang Zhu, Lilach O. Lerman
openaire   +1 more source