Results 111 to 120 of about 1,347 (176)

Metabolite Profiling of Rambutan (Nephelium lappaceum L.) Seeds Using UPLC-qTOF-MS/MS and Senomorphic Effects in Aged Human Dermal Fibroblasts

, 2020
Nephelium lappaceum (rambutan) is an edible tropical fruit that is widely grown in Southeast Asia. In general, the seeds contain high nutrients, but rambutan seeds are thrown out during processing. In this study, the anti-aging activity of rambutan seeds
Mi Zhang, Yae Rin Lee, Cho, Hyo Moon, Zhang, Mi, Hyo Moon Cho, Park, Eun Jin, Cho, Kyung A., Lee, Ba Wool, Won Keun Oh, Thi Phuong Doan, Kyung A Cho, Oh, Won Keun, Eun Jin Park, Lee, Yae Rin, Ba Wool Lee   +14 more
core   +1 more source

The senomorphic impact of astaxanthin on irradiated rat spleen: STING, TLR4 and mTOR contributed pathway

International Journal of Immunopathology and Pharmacology
Objectives: Exposure of spleen tissues to ionizing radiation during radiotherapy can induce cellular stress and immune-dysfunction leading to cellular senescence. Introduction: The process of a cancerous development is facilitated by the accumulation of senescent cells.
Maha M Aziz, Marwa M El-Sheikh, Marwa A Mohamed, Sahar S Abdelrahman, Mai H Mekkawy   +4 more
openaire   +2 more sources

Senescence associated osteoarthritis: Emerging therapeutics and future directions

Clinical Immunology Communications
Osteoarthritis is a degenerative condition that primarily affects the joints. This condition is often marked by the slow degradation of cartilage as well as changes in the subchondral bone. One of the key markers of osteoarthritis is chronic inflammation.
Sheen Razdan, Anush Tomar, Sweta Bawari
doaj   +1 more source

Identification of Senomorphic miRNAs in Embryonic Progenitor and Adult Stem Cell‐Derived Extracellular Vesicles

Aging Cell
ABSTRACT Extracellular vesicles (EVs) are secreted by most cell types, transmitting crucial signaling molecules like proteins, small RNAs, and DNA. We previously demonstrated that EVs from murine and human mesenchymal stem cells (MSCs) functioned as senomorphics to suppress markers of senescence and the ...
Tianpeng Zhang, Allancer D. C. Nunes, Jieun Lee, Dana Larocca, Giovanni Camussi, Sai Kiang Lim, Vicky U. Bascones, Luise Angelini, Ryan D. O'Kelly, Xiao Dong, Laura J. Niedernhofer, Paul D. Robbins   +11 more
openaire   +2 more sources

Therapy-induced senescence in prostate cancer: mechanisms, therapeutic strategies, and clinical implications [PDF]

Cellular senescence; Prostate cancer; Senescence-associated secretory phenotypeSenescència cel·lular; Càncer de pròstata; Fenotip secretor associat a la senescènciaSenescencia celular; Cáncer de próstata; Fenotipo secretor asociado a la ...
Labbé, David, Brandariz, Julian, Zacchi, Francesca, Zivi, Andrea, Bacca, Luisa, Mateo, Joaquin   +5 more
core   +1 more source

From Senescent Cells to Systemic Inflammation: The Role of Inflammaging in Age-Related Diseases and Kidney Dysfunction

Cells
Aging is characterized by a chronic, low-grade inflammatory state known as inflammaging, which closely interacts with immunosenescence—the gradual deterioration of immune function.
Federica De Luca, Valentina Camporeale, Giorgia Leccese, Roberto Cuttano, Dario Troise, Barbara Infante, Giovanni Stallone, Giuseppe Stefano Netti, Elena Ranieri   +8 more
doaj   +1 more source

Senolytic and senomorphic agent procyanidin C1 alleviates structural and functional decline in the aged retina

Proceedings of the National Academy of Sciences
Increased cellular senescence burden contributes in part to age-related organ dysfunction and pathologies. In our study, using mouse models of natural aging, we observed structural and functional decline in the aged retina, which was accompanied by the accumulation of senescent cells and senescence-associated secretory phenotype factors.
Yidan Liu, Xiuxing Liu, Xuhao Chen, Zhenlan Yang, Jianqi Chen, Weining Zhu, Yangyang Li, Yuwen Wen, Caibin Deng, Chenyang Gu, Jianjie Lv, Rong Ju, Yehong Zhuo, Wenru Su   +13 more
openaire   +2 more sources

Activation of senescence in critically ill patients: mechanisms, consequences and therapeutic opportunities

Annals of Intensive Care
Whereas aging is a whole-organism process, senescence is a cell mechanism that can be triggered by several stimuli. There is increasing evidence that critical conditions activate cell senescence programs irrespective of patient’s age.
Paula Martín-Vicente, Cecilia López-Martínez, Beatriz Rioseras, Guillermo M. Albaiceta   +3 more
doaj   +1 more source

Pyrroloquinoline Quinone Is an Effective Senomorphic Agent to Target the Pro‐Inflammatory Phenotype of Senescent Cells

Aging Cell
ABSTRACTCellular senescence is an aging‐related mechanism characterized by cell cycle arrest, macromolecular alterations, and a senescence‐associated secretory phenotype (SASP). Recent preclinical trials established that senolytic drugs, which target survival mechanisms of senescent cells, can effectively intervene in age‐related pathologies.
Birong Jiang, Hongwei Zhang, Qixia Xu, Zhirui Jiang, Ruikun He, Qiang Fu, Yu Sun   +6 more
openaire   +2 more sources

The Senescence-Associated Secretory Phenotype: Induction, Regulation, Function and Therapeutic Interventions to Counteract the Negative Effects

Aging is characterized by a status of chronic low-grade systemic inflammation called “inflammaging”, that represents a leading cause of diseases typical of advanced age.
Frasca, Daniela
core   +1 more source