Results 91 to 100 of about 1,543 (178)

Exploring Senolytic and Senomorphic Properties of Medicinal Plants for Anti-Aging Therapies

International Journal of Molecular Sciences
Senolytic and senomorphic therapies gain more and more attention in the last decade. This kind of therapy is based on the killing of cellular senescent cells without harming the “normal” cells. Ageing is not a disease. Clinical studies on healthy people will be difficult to conduct.
Monika Imb, Zsolt Véghelyi, Michael Maurer, Harald Kühnel   +3 more
openaire   +2 more sources

The bright and dark side of skin senescence. Could skin rejuvenation anti-senescence interventions become a “bright” new strategy for the prevention of age-related skin pathologies?

, 2021
The number of senescent cells in the skin is increasing with age. Numerous studies have attempted to elucidate the role of these cells in normal aging of the skin as well as in age-related skin conditions. In recent years, attempts have also been made to
Valsamidi, C., Georgakopoulou, E.A., Veroutis, D., Havaki, S.   +3 more
core   +1 more source

Targeting Cellular Senescence in Prostate Cancer: Molecular Landscape and Therapeutic Avenues

Annals of Urologic Oncology
Prostate cancer is one of the major causes of cancer morbidity and mortality in men, especially at advanced stages where treatment fails. Despite the fact that the existing treatment options, such as androgen deprivation therapy, chemotherapy ...
Haneen Hossam, Bandar Alattaibi
doaj   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, Volume 7, Issue 4, August 2026.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Ammonia Metabolism in the Aging Liver: Emerging Mechanistic Insights

Aging Cell, Volume 25, Issue 8, August 2026.
Liver aging may weaken ammonia‐detoxification reserve by disrupting mitochondrial ureagenesis, GS‐mediated scavenging, glutamine metabolism, and metabolic zonation. This emerging framework links impaired nitrogen handling to potential hepatic stress amplification and systemic crosstalk, while highlighting the need for direct validation in physiological
Heng Zhang, Guangyu Liang, Anding Liu
wiley   +1 more source

Cellular Senescence in Skeletal Muscle Aging [PDF]

Endocrinology and Metabolism
Cellular senescence is increasingly recognized as a pivotal mechanism driving skeletal muscle aging and the development of sarcopenia, a condition characterized by the progressive loss of muscle mass, strength, and function.
Yang Li, Huating Wang
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Effective and Stable Senomorphic Apigenin Delivery System Obtained by Supercritical Carbon Dioxide Processing

International Journal of Molecular Sciences
Apigenin (AP) is a natural flavonoid with senomorphic potential and neuroprotective action; however, poor aqueous solubility (<1 μg/mL) limits its bioavailability and therapeutic use. Therefore, the aim of this study was to obtain an amorphous dispersion of AP and evaluate its biological properties.
Anna Stasiłowicz-Krzemień, Natalia Rosiak, Giuseppe Francesco Racaniello, Nunzio Denora, Judyta Cielecka-Piontek   +4 more
openaire   +3 more sources

Reprogramming the mitochondrial-circadian energy code with incretins

Mitochondrial dysfunction, circadian disruption, and the accumulation of senescent cells converge to impair metabolic flexibility, a unifying phenotype of obesity and aging. We frame obesity as a nutrient-driven and aging as a time-driven expression of a
Maurizio Ragni, Enzo Nisoli, Alessandra Valerio, Chiara Ruocco   +3 more
core   +1 more source

Senescence associated osteoarthritis: Emerging therapeutics and future directions

Clinical Immunology Communications
Osteoarthritis is a degenerative condition that primarily affects the joints. This condition is often marked by the slow degradation of cartilage as well as changes in the subchondral bone. One of the key markers of osteoarthritis is chronic inflammation.
Sheen Razdan, Anush Tomar, Sweta Bawari
doaj   +1 more source