Results 91 to 100 of about 1,171 (158)

Activation of senescence in critically ill patients: mechanisms, consequences and therapeutic opportunities

Annals of Intensive Care
Whereas aging is a whole-organism process, senescence is a cell mechanism that can be triggered by several stimuli. There is increasing evidence that critical conditions activate cell senescence programs irrespective of patient’s age.
Paula Martín-Vicente, Cecilia López-Martínez, Beatriz Rioseras, Guillermo M. Albaiceta   +3 more
doaj   +1 more source

Effective and Stable Senomorphic Apigenin Delivery System Obtained by Supercritical Carbon Dioxide Processing

International Journal of Molecular Sciences
Apigenin (AP) is a natural flavonoid with senomorphic potential and neuroprotective action; however, poor aqueous solubility (<1 μg/mL) limits its bioavailability and therapeutic use. Therefore, the aim of this study was to obtain an amorphous dispersion of AP and evaluate its biological properties.
Anna Stasiłowicz-Krzemień, Natalia Rosiak, Giuseppe Francesco Racaniello, Nunzio Denora, Judyta Cielecka-Piontek   +4 more
openaire   +2 more sources

Senolytic and senomorphic agent procyanidin C1 alleviates structural and functional decline in the aged retina

Proceedings of the National Academy of Sciences
Increased cellular senescence burden contributes in part to age-related organ dysfunction and pathologies. In our study, using mouse models of natural aging, we observed structural and functional decline in the aged retina, which was accompanied by the accumulation of senescent cells and senescence-associated secretory phenotype factors.
Yidan Liu, Xiuxing Liu, Xuhao Chen, Zhenlan Yang, Jianqi Chen, Weining Zhu, Yangyang Li, Yuwen Wen, Caibin Deng, Chenyang Gu, Jianjie Lv, Rong Ju, Yehong Zhuo, Wenru Su   +13 more
openaire   +2 more sources

The senomorphic impact of astaxanthin on irradiated rat spleen: STING, TLR4 and mTOR contributed pathway

International Journal of Immunopathology and Pharmacology
Objectives: Exposure of spleen tissues to ionizing radiation during radiotherapy can induce cellular stress and immune-dysfunction leading to cellular senescence. Introduction: The process of a cancerous development is facilitated by the accumulation of senescent cells.
Maha M Aziz, Marwa M El-Sheikh, Marwa A Mohamed, Sahar S Abdelrahman, Mai H Mekkawy   +4 more
openaire   +2 more sources

Ruxolitinib-based senomorphic therapy mitigates cardiomyocyte senescence in septic cardiomyopathy by inhibiting the JAK2/STAT3 signaling pathway

International Journal of Biological Sciences
Background: Cellular senescence has emerged as a pivotal focus in cardiovascular research. This study investigates the previously unrecognized role of cellular senescence in septic cardiomyopathy (SCM) and evaluates senomorphic therapy using ruxolitinib (Rux) as a potential treatment option.
Yang, Boshen, Li, Taixi, Wang, Zhixiang, Zhu, Yuankang, Niu, Kaifan, Hu, Sien, Lin, Zhiqi, Zheng, Xinjie, Jin, Xian, Shen, Chengxing   +9 more
openaire   +2 more sources

Chronic Kidney Disease and Cellular Senescence. [PDF]

Int J Mol Sci
Morevati M, Tavenier J, Scheibye-Knudsen M, Houlind MB, Hedayati A, Hornum M.   +5 more
europepmc   +1 more source

The geroscience hypothesis: Economic paradigms and pharmacological strategies for healthspan extension. [PDF]

J Taibah Univ Med Sci
Alotaibi AF, Aljasser AI, Alkattan AN, Alkhoraisi A, Assiri AM.   +4 more
europepmc   +1 more source

Senescence Modulation: An Applied Science Review of Strategies in Anti-Aging, Regenerative Aesthetics, and Oncology Therapy. [PDF]

Curr Issues Mol Biol
Kusmanto SJ.
europepmc   +1 more source

Conquering aging-related immunosenescence and tumor immune escape. [PDF]

Front Immunol
Zhang S, Yang B, Xu M, Bing Y, Zhang J, Wang Y, Zheng C, Zhang G, Zhang L.   +8 more
europepmc   +1 more source

Impairment of Macrophage Functions by the Senescence-Associated Secretory Phenotype of Vascular Smooth Muscle Cells-Brief Report. [PDF]

Arterioscler Thromb Vasc Biol
Tsitsipatis D, Rodriguez Rivera T, Kaileh M, Okereke AN, Gupta A, Singh A, Raph SM, Henry-Smith C, Herman AB.   +8 more
europepmc   +1 more source