Results 41 to 50 of about 1,347 (176)
Targeting cellular senescence with senotherapeutics: senolytics and senomorphics [PDF]
The FEBS Journal, 2022 The concept of geroscience is that since ageing is the greatest risk factor for many diseases and conditions, targeting the ageing process itself will have the greatest impact on human health. Of the hallmarks of ageing, cellular senescence has emerged as a druggable therapeutic target for extending healthspan in model organisms. Cellular senescence is
Lei Zhang +4 more
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Cellular senescence in lung cancer immune microenvironment and senotherapeutic opportunities [PDF]
iScienceSummary: Cellular senescence (CS) shapes lung cancer biology by enforcing durable growth arrest while remodeling the tumor immune microenvironment (TIME) through the senescence-associated secretory phenotype (SASP). In non-small cell lung cancer (NSCLC),
Zhaolin Xu +3 more
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Targeting immunosenescence in lung diseases: mechanistic insights and clinical interventions [PDF]
BMC MedicineImmunosenescence, the age-related decline in immune function, plays a crucial role in the pathogenesis and progression of lung diseases, including chronic obstructive pulmonary disease, lung cancer, pulmonary fibrosis, asthma, and respiratory tract ...
Yin Zhang +5 more
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HSP90 acts as a senomorphic target in senescent retinal pigmental epithelial cells [PDF]
Aging, 2021 The senescence of retinal pigment epithelial (RPE) cells is associated with age-related macular degeneration (AMD), a leading cause of blindness in the world. HSP90 is a predominant chaperone that regulates cellular homeostasis under divergent physio-pathological conditions including senescence.
Chen, Dan-Dan +12 more
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Cellular Senescence in Cardiovascular Diseases: From Pathogenesis to Therapeutic Challenges
Journal of Cardiovascular Development and Disease, 2023 Cellular senescence (CS), classically considered a stable cell cycle withdrawal, is hallmarked by a progressive decrease in cell growth, differentiation, and biological activities.
Dan Li +5 more
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Action Mechanisms of Small Extracellular Vesicles in Inflammaging
Life, 2022 The accumulation process of proinflammatory components in the body due to aging influences intercellular communication and is known as inflammaging. This biological mechanism relates the development of inflammation to the aging process.
Rocío Mato-Basalo +10 more
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Cellular senescence and the tumour microenvironment
Molecular Oncology, 2022 The senescence‐associated secretory phenotype (SASP), where senescent cells produce a variety of secreted proteins including inflammatory cytokines, chemokines, matrix remodelling factors, growth factors and so on, plays pivotal but varying roles in the ...
Masaki Takasugi +2 more
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Frontiers in Endocrinology, 2023 Recent advances in aging research have provided novel insights for the development of senotherapy, which utilizes cellular senescence as a therapeutic target.
Sachi Matsubayashi +3 more
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From genoprotection to rejuvenation
Frontiers in Bioscience-Landmark, 2020 Aging results from aberrations in signaling mechanisms and decline in biologic activities and cellular functions. Anti-aging strategies include a number of dietary, genetic, and pharmacological interventions that converge on a core network of nutrient ...
Siamak Tabibzadeh
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Frontiers in Aging, 2023 Introduction: Doxorubicin (DOX), a chemotherapeutic drug, induces senescence and increases the secretion of senescence-associated secretory phenotype (SASP) in endothelial cells (ECs), which contributes to DOX-induced inflammaging.
Ibrahim Y. Abdelgawad +4 more
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