Results 31 to 40 of about 10,262,985 (255)

G3BP1 controls the senescence-associated secretome and its impact on cancer progression

Nature Communications, 2020
The mechanisms that control the deleterious behaviour of senescent cells is unclear. Here, the authors show that G3BP1 is required for the induction of the senescence-associated secretory phenotype (SASP), without affecting senescence, and that SASP ...
Amr Omer, Monica Cruz Barrera, Julian L. Moran, Xian J. Lian, Sergio Di Marco, Christian Beausejour, Imed-Eddine Gallouzi   +6 more
doaj   +1 more source

Single-cell transcriptomics identifies senescence-associated secretory phenotype (SASP) features of testicular aging in human. [PDF]

Aging (Albany NY)
The male reproductive system experiences degradation with age, predominantly impacting the testes. Testicular aging can result in failure to produce physiological testosterone levels, normal sperm concentrations, or both. However, we cannot predict the onset of testicular aging in advance.
He J, Li J, Li Y, Xu Z, Ma M, Chen H, Chen P, Lv L, Shang X, Liu G.   +9 more
europepmc   +3 more sources

Senescence-associated extracellular vesicle release plays a role in senescence-associated secretory phenotype (SASP) in age-associated diseases [PDF]

The Journal of Biochemistry, 2020
Abstract Cellular senescence is an important tumour suppression mechanism that inhibits the proliferation of damaged cells. In senescent cells, irreparable DNA damage causes accumulation of genomic DNA fragments in the cytoplasm, which are recognized by the cyclic GMP-AMP synthase–stimulator of interferon gene pathway, resulting in ...
Yoko, Tanaka, Akiko, Takahashi
openaire   +2 more sources

The long non-coding RNA MIR31HG regulates the senescence associated secretory phenotype

Nature Communications, 2021
Senescence-associated secretory phenotype (SASP) involves secretion of factors such as pro-inflammatory cytokines. Here the authors show that MIR31HG regulates the expression and secretion of a subset of SASP components that induce paracrine invasion ...
Marta Montes, Michal Lubas, Frederic S. Arendrup, Bettina Mentz, Neha Rohatgi, Sarunas Tumas, Lea M. Harder, Anders J. Skanderup, Jens S. Andersen, Anders H. Lund   +9 more
doaj   +1 more source

Redox control of senescence and age-related disease

Redox Biology, 2017
The signaling networks that drive the aging process, associated functional deterioration, and pathologies has captured the scientific community's attention for decades.
Akshaya Chandrasekaran, Maria del Pilar Sosa Idelchik, J. Andrés Melendez   +2 more
doaj   +1 more source

Optimisation of a screening platform for determining IL-6 inflammatory signalling in the senescence-associated secretory phenotype (SASP). [PDF]

Biogerontology, 2019
Cellular senescence has been shown to be sufficient for the development of multiple age-related pathologies. Senescent cells adopt a secretory phenotype (the SASP) which comprises a large number of pro-inflammatory cytokines, chemokines and proteases. The SASP itself is thought to be causative in many pathologies of age-related diseases, and there is ...
Rolt A, Nair A, Cox LS.
europepmc   +5 more sources

HMGB2 holds the key to the senescence-associated secretory phenotype [PDF]

, 2016
The senescence - associated secretory phenotype (SASP) is a hallmark of senescence with important physiological impact, but how it is established is unclear . In this issue , Aird and colleagues ( 2016. J Cell Biol.
guerrero a, Gil, J, Jesús Gil, Ana Guerrero   +3 more
core   +1 more source

Folic Acid Supplementation Suppresses Sleep Deprivation-Induced Telomere Dysfunction and Senescence-Associated Secretory Phenotype (SASP). [PDF]

Oxid Med Cell Longev, 2019
Sleep deprivation is reported to cause oxidative stress and is hypothesized to induce subsequent aging-related diseases including chronic inflammation, Alzheimer’s disease, and cardiovascular disease. However, how sleep deprivation contributes to the pathogenesis of sleep deficiency disorder remains incompletely defined.
Zhang X, Wang Y, Zhao R, Hu X, Zhang B, Lv X, Guo Z, Zhang Z, Yuan J, Chu X, Wang F, Li G, Geng X, Liu Y, Sui L, Wang F.   +15 more
europepmc   +3 more sources

Senescence-associated secretory phenotype (SASP) and uterine fibroids: Association with PD-L1 activation and collagen deposition. [PDF]

Ageing Res Rev
Uterine fibroids (or uterine leiomyoma, UFs) are one of the most prevalent benign uterine tumors with high proliferation and collagen synthesis capabilities. UFs are a significant worldwide health issue for women, affecting their physical and financial well-being.
Saad EE, Michel R, Borahay MA.
europepmc   +3 more sources

Gene expression of senescence and SASP markers in ALGS livers.

, 2023
(A) Gene expression of p21 and p16 increases in ALGS livers. (B) Gene expression of SASP markers TGF-β1, IL-6 and IL-8 is unchanged in ALGS livers. ALGS: Alagille syndrome; SASP: senescence-associated secretory phenotype. Data is presented as mean ± SD; *
Mustapha Najimi (143882), Catherine de Magnée (11086299), Roberto Tambucci (11086296), Jonathan Evraerts (511703), Giulia Jannone (8560338), Joachim Ravau (15361100), Etienne Marc Sokal (15361103)   +6 more
core   +1 more source