Results 21 to 30 of about 17,888 (258)

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)

Cellular Signalling, 2012
The major hallmark of cellular senescence is an irreversible cell cycle arrest and thus it is a potent tumor suppressor mechanism. Genotoxic insults, e.g. oxidative stress, are important inducers of the senescent phenotype which is characterized by an accumulation of senescence-associated heterochromatic foci (SAHF) and DNA segments with chromatin ...
Salminen, Antero, Kauppinen, Anu, Kaarniranta, Kai   +2 more
openaire   +3 more sources

Mechanisms and therapeutic strategies for senescence-associated secretory phenotype in the intervertebral disc degeneration microenvironment

Journal of Orthopaedic Translation
As a permanent state of cell cycle arrest, cellular senescence has become an important factor in aging and age-related diseases. As a central regulator of physiology and pathology associated with cellular senescence, the senescence associated secretory ...
Yang Liu, Yiming Dou, Xun Sun, Qiang Yang   +3 more
doaj   +2 more sources

COPD-derived fibroblasts secrete higher levels of senescence-associated secretory phenotype proteins [PDF]

Thorax, 2020
COPD-derived fibroblasts have increased cellular senescence. Senescent cell accumulation can induce tissue dysfunction by their senescence-associated secretory phenotype (SASP). We aimed to determine the SASP of senescent fibroblasts and COPD-derived lung fibroblasts, including severe, early-onset (SEO)-COPD.
Roy R Woldhuis, Irene H Heijink, Maarten van den Berge, Wim Timens, Brian G G Oliver, Maaike de Vries, Corry-Anke Brandsma   +6 more
core   +7 more sources

Deciphering the mechanism for induction of senescence-associated secretory phenotype (SASP) and its role in ageing and cancer development

Journal of Biochemistry, 2019
Abstract Cellular senescence is an irreversible form of cell cycle arrest that can be induced by persistent DNA damage, and is well known to function as an important tumour suppression mechanism. Cellular senescence is detected in aged organisms; thus, it is also recognized as a hallmark of organismal ageing.
Naoko Ohtani, Ohtani Naoko
exaly   +3 more sources

Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses

Aging, 2016
Senescent cells secrete senescence-associated secretory phenotype (SASP) proteins to carry out several functions, such as sensitizing surrounding cells to senesce; immunomodulation; impairing or fostering cancer growth; and promoting tissue development.
Özcan, Servet, Alessio, Nicola, Acar, Mustafa B, Mert, Eda, Omerli, Fatih, PELUSO, Gianfranco, GALDERISI, Umberto   +6 more
openaire   +5 more sources

Recent advances in senescence-associated secretory phenotype and osteoporosis

Heliyon
The worldwide elderly population is on the rise, and aging is a major osteoporosis risk factor. Senescent cells accumulation can have a detrimental effect the body as we age.
Haonan Fan, Zhi Qiao, Jitian Li, Guowei Shang, Chunfeng Shang, Songfeng Chen, Zikuan Leng, Huifang Su, Hongwei Kou, Hongjian Liu   +9 more
doaj   +2 more sources

Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy

Frontiers in Oncology, 2018
In addition to promoting various forms of cell death, most conventional anti-tumor therapies also promote senescence. There is now extensive evidence that therapy-induced senescence (TIS) might be transient, raising the concern that TIS could represent ...
Tareq Saleh, Tareq Saleh, Liliya Tyutynuk-Massey, Liliya Tyutynuk-Massey, Emmanuel K. Cudjoe, Michael O. Idowu, Joseph W. Landry, Joseph W. Landry, David A. Gewirtz, David A. Gewirtz   +9 more
doaj   +2 more sources

Cell enlargement modulated by GATA4 and YAP instructs the senescence-associated secretory phenotype

Nature Communications
Dynamic changes in cell size are associated with development and pathological conditions, including aging. Although cell enlargement is a prominent morphological feature of cellular senescence, its functional implications are unknown; moreover, how ...
Joae Joung, Yekang Heo, Yeonju Kim, Jaejin Kim, Haebeen Choi, Taerang Jeon, Yeji Jang, Eun-Jung Kim, Sang Heon Lee, Jae Myoung Suh, Stephen J. Elledge, Mi-Sung Kim, Chanhee Kang   +12 more
doaj   +2 more sources

TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state

Cell Reports, 2023
Summary: TGF-β induces senescence in embryonic tissues. Whether TGF-β in the hypoxic tumor microenvironment (TME) induces senescence in cancer and how the ensuing senescence-associated secretory phenotype (SASP) remodels the cellular TME to influence ...
Satoru Matsuda, Ajinkya Revandkar, Taronish D. Dubash, Arvind Ravi, Ben S. Wittner, Maoxuan Lin, Robert Morris, Risa Burr, Hongshan Guo, Karsen Seeger, Annamaria Szabolcs, Dante Che, Linda Nieman, Gad A. Getz, David T. Ting, Michael S. Lawrence, Justin Gainor, Daniel A. Haber, Shyamala Maheswaran   +18 more
doaj   +1 more source

The Paradoxical Role of Cellular Senescence in Cancer

Frontiers in Cell and Developmental Biology, 2021
Cellular senescence occurs in proliferating cells as a consequence of various triggers including telomere shortening, DNA damage, and inappropriate expression of oncogenes.
Jing Yang, Jing Yang, Mengmeng Liu, Mengmeng Liu, Dongchun Hong, Dongchun Hong, Musheng Zeng, Xing Zhang   +7 more
doaj   +1 more source