Results 21 to 30 of about 10,262,985 (255)

Myeloma-Modified Adipocytes Exhibit Metabolic Dysfunction and a Senescence-Associated Secretory Phenotype. [PDF]

Cancer Res, 2021
Abstract Bone marrow adipocytes (BMAd) have recently been implicated in accelerating bone metastatic cancers, such as acute myelogenous leukemia and breast cancer. Importantly, bone marrow adipose tissue (BMAT) expands with aging and obesity, two key risk factors in multiple myeloma disease ...
Fairfield H, Dudakovic A, Khatib CM, Farrell M, Costa S, Falank C, Hinge M, Murphy CS, DeMambro V, Pettitt JA, Lary CW, Driscoll HE, McDonald MM, Kassem M, Rosen C, Andersen TL, van Wijnen AJ, Jafari A, Reagan MR.   +18 more
europepmc   +6 more sources

Late Depression and Senescence-Associated Secretory Phenotype (SASP) [PDF]

Eur Psychiatry
IntroductionNeurobiological mechanisms of late depression include abnormal regulation and interaction of multiple biological processes, as well as abnormalities of brain structures and organs.Objectivesliterature analysisMethodsgeneral scientific methodResultsThe results of the study show that the SASP index as an integral indicator of changes in ...
Sidenkova A.
europepmc   +2 more sources

The Paradoxical Role of Cellular Senescence in Cancer

Frontiers in Cell and Developmental Biology, 2021
Cellular senescence occurs in proliferating cells as a consequence of various triggers including telomere shortening, DNA damage, and inappropriate expression of oncogenes.
Jing Yang, Jing Yang, Mengmeng Liu, Mengmeng Liu, Dongchun Hong, Dongchun Hong, Musheng Zeng, Xing Zhang   +7 more
doaj   +1 more source

TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state

Cell Reports, 2023
Summary: TGF-β induces senescence in embryonic tissues. Whether TGF-β in the hypoxic tumor microenvironment (TME) induces senescence in cancer and how the ensuing senescence-associated secretory phenotype (SASP) remodels the cellular TME to influence ...
Satoru Matsuda, Ajinkya Revandkar, Taronish D. Dubash, Arvind Ravi, Ben S. Wittner, Maoxuan Lin, Robert Morris, Risa Burr, Hongshan Guo, Karsen Seeger, Annamaria Szabolcs, Dante Che, Linda Nieman, Gad A. Getz, David T. Ting, Michael S. Lawrence, Justin Gainor, Daniel A. Haber, Shyamala Maheswaran   +18 more
doaj   +1 more source

Altered regulation of mesenchymal cell senescence in adipose tissue promotes pathological changes associated with diabetic wound healing

Communications Biology, 2022
Type-2 diabetic adipose tissue impairs transient senescence during wound healing with expression of different components of the senescence-associated secretory phenotype (SASP), and this is associated with deteriorated wound healing.
Arisa Kita, Yuki Saito, Norihiro Miura, Maki Miyajima, Sena Yamamoto, Tsukasa Sato, Takatoshi Yotsuyanagi, Mineko Fujimiya, Takako S. Chikenji   +8 more
doaj   +1 more source

Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling

Nature Communications, 2023
Cellular senescence and associated secretory phenotype (SASP) are thought to contribute to aging and tissue dysfunction, though it is unclear how SASP impacts regeneration.
Jina Yun, Simon Hansen, Otto Morris, David T. Madden, Clare Peters Libeu, Arjun J. Kumar, Cameron Wehrfritz, Aaron H. Nile, Yingnan Zhang, Lijuan Zhou, Yuxin Liang, Zora Modrusan, Michelle B. Chen, Christopher C. Overall, David Garfield, Judith Campisi, Birgit Schilling, Rami N. Hannoush, Heinrich Jasper   +18 more
doaj   +1 more source

Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature. [PDF]

Eur J Med Res
AbstractThe senescence-associated secretory phenotype (SASP) is a generic term for the secretion of cytokines, such as pro-inflammatory factors and proteases. It is a crucial feature of senescent cells. SASP factors induce tissue remodeling and immune cell recruitment.
Zhao S, Qiao Z, Pfeifer R, Pape HC, Mao K, Tang H, Meng B, Chen S, Liu H.   +8 more
europepmc   +5 more sources

Inflammaging and Senescence-Associated Secretory Phenotype (SASP) in Psoriasis - A Narrative Review of Potential Mechanisms and Anti-Inflammaging Strategies. [PDF]

Psoriasis (Auckl)
Psoriasis is a common chronic dermatological disease, affecting approximately 1-3% of the global population, and is associated with numerous comorbidities, impaired quality of life, and reduced life expectancy compared with the general population. The pathogenesis of psoriasis is complex and multifactorial, involving genetic susceptibility, external ...
Filipek K, Nowowiejska-Purpurowicz J, Flisiak I.   +2 more
europepmc   +5 more sources

Inhibition of the metalloprotease ADAM19 as a novel senomorphic strategy to ameliorate gut permeability and senescence markers by modulating senescence-associated secretory phenotype (SASP). [PDF]

Aging (Albany NY)
Accumulation of DNA damage can accelerate aging through cellular senescence. Previously, we established a Drosophila model to investigate the effects of radiation-induced DNA damage on the intestine.
Bar S, Hilsabeck TAU, Pattavina B, López-Domínguez JA, Basisty N, Bons J, Watson M, Schilling B, Campisi J, Kapahi P, Sharma A.   +10 more
europepmc   +2 more sources

Physiological hypoxia restrains the Senescence Associated Secretory Phenotype (SASP) via AMPK-mediated mTOR suppression. Vliet T et al

, 2021
Original images and blots of Physiological hypoxia restrains the Senescence Associated Secretory Phenotype (SASP) via AMPK-mediated mTOR suppression.
Restoring Organ Function by Means of Regenerative Medicine (REGENERATE), Demaria, Marco; id_orcid, Demaria, Marco, Damage and Repair in Cancer Development and Cancer Treatment (DARE)   +3 more
core   +1 more source