Results 41 to 50 of about 22,235 (292)
AISA can control the inflammatory facet of SASP
Mechanisms of Ageing and Development, 2020 Senescent cells have been suspected, because of their secretory phenotype (SASP or Senescence Associated Secretory Profile), to contribute to the extension of the chronic inflammatory condition leading to unhealthy aging processes. AISA (Anti-Inflammatory Senescence Actives) monoterpens have been characterized as possessing anti-inflammatory capacities
Patrizia A, d'Alessio, Marie C, Béné
openaire +3 more sources
, 2013 Sonograms of the songs included in this repository. Examples of five different song types (defined by the "middle" section of the song) are shown for six recording periods spanning the years from 1980 to ...
Iris I. Levin (792911) +9 more
core +1 more source
The role of senescence-associated secretory phenotype (SASP) in cellular senescene
Acta Biochimica Indonesiana, 2021 Cellular senescence is one of the defense mechanisms of cells against oncogenic signals by permanently stopping the proliferation of the cell. Senescence cells show a similar characteristic, one of them is senescence-associated secretory phenotype (SASP).
Filda Vionita Irene de Lime +1 more
doaj +1 more source
Figure E2: Release of SASP factors from enriched senescent COPD SAF.
, 2023 Figure E2: Release of SASP factors from enriched senescent COPD SAF. SAF from COPD donors were sorted using FACS and sorted into 10% smallest and least autofluorescent (FSClowFITClow, ●) and 10% largest and most autofluorescent (FSChighFITChigh ...
Catherine Wrench (14030376)
core +1 more source
Ecotoxicology and Environmental Safety, 2021 Hexavalent chromium [Cr(VI)] and its compounds have caused serious environmental pollution and health damage. Senescent cells can actively change the surrounding environment by secreting some factors, which are called senescence associated secretory ...
Yuehui Liang +5 more
doaj +1 more source
(-)-α-Bisabolol inhibits D-Gal-induced HSF cellular senescence in vitro and prevents skin aging in vivo by reducing SASP [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): To study the anti-aging effect of (-)-α-bisabolol ((-)-α-bis) on the skin and preliminarily clarify its mechanism. Materials and Methods: Human skin fibroblasts (HSF) were induced senescence by D-Galactose.
Meixing He +7 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Environmental Health and Preventive MedicineBackground: Chronic arsenite exposure has been known to induce cancer in various organs; however, the underlying mechanisms remain elusive. The characteristic feature of carcinogenesis due to arsenic exposure is that the disease develops after a ...
Kazuyuki Okamura +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source