Senescence-associated secretory phenotype and its impact on oral immune homeostasis
Frontiers in Immunology, 2022 The senescence-associated secretory phenotype (SASP), which accumulates over the course of normal aging and in age-related diseases, is a crucial driver of chronic inflammation and aging phenotypes. It is also responsible for the pathogenesis of multiple
Ziqi Yue +12 more
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Probiotic bacteria as modulators of cellular senescence: emerging concepts and opportunities
Gut Microbes, 2020 Probiotic bacteria are increasingly gaining importance in human nutrition owing to their multifaceted health beneficial effects. Studies have also shown that probiotic supplementation is useful in mitigating age-associated oxi-inflammatory stress ...
Rohit Sharma, Yogendra Padwad
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SASP Atlas: A comprehensive resource for SASPs.
, 2020 SASP Atlas (www.SASPAtlas.com) is a curated and freely available database of the secretomes of senescent cells, including both the soluble and exosome SASP, that can be used to identify SASP components or biomarker candidates for senescence burden, aging,
Luigi Ferrucci (150038) +11 more
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Engineered Bacteriophage as a Delivery Vehicle for Antibacterial Protein, SASP [PDF]
Pharmaceuticals, 2021 The difficulties in developing novel classes of antibacterials is leading to a resurgence of interest in bacteriophages as therapeutic agents, and in particular engineered phages that can be optimally designed. Here, pre-clinical microbiology assessment is presented of a Staphylococcus aureus phage engineered to deliver a gene encoding an antibacterial
Cass, James +2 more
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Optimisation of a screening platform for determining IL-6 inflammatory signalling in the senescence-associated secretory phenotype (SASP) [PDF]
, 2020 Cellular senescence has been shown to be sufficient for the development of multiple age-related pathologies. Senescent cells adopt a secretory phenotype (the SASP) which comprises a large number of pro-inflammatory cytokines, chemokines and proteases ...
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Dual role of PRMT1-dependent arginine methylation in cellular responses to genotoxic stress
Molecular & Cellular Oncology, 2020 We have recently shown that arginine methylation by protein arginine N-methyltransferase 1 (PRMT1) controls the response to cisplatin in ovarian cancer cells.
Roberto Giambruno, Tiziana Bonaldi
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Cancer cell cannibalism and the SASP: Ripples in the murky waters of tumor dormancy
Molecular & Cellular Oncology, 2017 Relapse in cancer patients following an apparent cure and a prolonged latency period, known as tumor dormancy, remains an unrelenting clinical crisis.
Thomas J. Bartosh
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Secondary amine selective Petasis (SASP) bioconjugation
Chemical Science, 2020 Secondary amine selective Petasis (SASP) bioconjugation for the selective labeling of peptides and proteins with N-terminal secondary amines.
Yonnette E. Sim +5 more
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Molecular & Cellular Oncology, 2020 The breast tumors that are most difficult to eradicate with chemotherapy have wild-type TP53 and preferentially enter senescence after treatment. One factor contributing to the persistence of senescent cells in residual disease: acquisition of a novel ...
Crystal A. Tonnessen-Murray +1 more
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The Senescence-Associated Secretory Phenotype (SASP) and Redox-Dependent Invasion of Metastatic Cancer Cells [PDF]
, 2012 Throughout your lifetime renewable tissues and those which are exposed to prolonged inflammation experience an accumulation of senescent cells. These cells have previously been shown to acquire the senescence-associated secretory phenotype (SASP) that ...
Pati, Brooke A.
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