Results 61 to 70 of about 22,235 (292)

Research Progress on the Regulation Mechanism of Senescence-associated Secretory Phenotype in Osteoporosis [PDF]

Zhongguo quanke yixue
Senescence-associated secretory phenotype (SASP) is an important feature of cellular senescence and plays an important role in regulating the disease microenvironment.
YANG Chaofu, TAN Guoqing, XU Zhanwang
doaj   +1 more source

Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling

Nature Communications, 2023
Cellular senescence and associated secretory phenotype (SASP) are thought to contribute to aging and tissue dysfunction, though it is unclear how SASP impacts regeneration.
Jina Yun, Simon Hansen, Otto Morris, David T. Madden, Clare Peters Libeu, Arjun J. Kumar, Cameron Wehrfritz, Aaron H. Nile, Yingnan Zhang, Lijuan Zhou, Yuxin Liang, Zora Modrusan, Michelle B. Chen, Christopher C. Overall, David Garfield, Judith Campisi, Birgit Schilling, Rami N. Hannoush, Heinrich Jasper   +18 more
doaj   +1 more source

SASP: roadblock for tissue re-organization

Aging, 2013
Senescence has been shown to prevent and promote tumorigenesis. [1, 2] These results are not so paradoxical. To develop and maintain, organisms rely on cellular growth and cell division. Each of these processes is spatiotemporally finely tuned and both are tightly coordinated to ensure organism homeostasis throughout life.
openaire   +2 more sources

Comparison of five wild-type mouse femurs to the core matrisome database and the Core SASP.

, 2023
A) Proteins identified from wild-type mouse femurs were compared to components of the core matrisome showing most representation to least representation as follows: Collagens (24 proteins), glycoproteins (71 proteins), proteoglycans (19 proteins), ECM ...
Jordan B. Burton (17125170), Christina D. King (8879360), Joanna Bons (9458931), Amy O’Broin (17125173), Birgit Schilling (31153), Tamara Alliston (265049), Sandip K. Patel (13041543), Jacob P. Rose (17125167), Charles A. Schurman (4386745)   +8 more
core   +1 more source

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Senescence-associated secretory phenotype constructed detrimental and beneficial subtypes and prognostic index for prostate cancer patients undergoing radical prostatectomy

Discover Oncology, 2023
Background Cellular senescence is growing in popularity in cancer. A dual function is played by the senescence-associated secretory phenotype (SASP) that senescent cells produce in the development of pro-inflammatory niches, tissue regeneration or ...
Dechao Feng, Jie Wang, Dengxiong Li, Ruicheng Wu, Wuran Wei, Chi Zhang   +5 more
doaj   +1 more source

Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells

, 2018
Accumulating evidence indicates that the senescence-associated secretory phenotype (SASP) contributes to many aspects of physiology and disease. Thus, controlling the SASP will have tremendous impacts on our health.
Watanabe, Yoshihiro, Fumitaka Kamachi, Naoko Ohtani, Hara, Eiji, Tze Mun Loo, Yoshihiro Watanabe, Takahashi, Akiko, Wakita, Masahiro, Masahiro Wakita, Kenichi Miyata, Kamachi, Fumitaka, Ohtani, Naoko, Loo, Tze Mun, Okada, Ryo, Sugiko Watanabe, Akiko Takahashi, Eiji Hara, Ryo Okada, Watanabe, Sugiko, Kawamoto, Shimpei, Glen N. Barber, Barber, Glen N, Shimpei Kawamoto, Miyata, Kenichi   +23 more
core   +1 more source

Bioadhesive Hydrogel With Polyphenol‐Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy

Advanced Science, EarlyView.
An adhesive hydrogel depot with polyphenol‐armored nanogenes is developed for treating aged osteoarthritis. This system maintains miR‐140 bioactivity, prolongs its intra‐articular retention, and enhances transfection into chondrocytes, leading to the downregulation of senescence‐associated pathways.
Liwei Yan, Runze Yang, Ting Zhou, Tianhao Xu, Yongqi Li, Yuelin Hu, Minghao Ge, Lei Zhang, Xiong Lu, Chaoming Xie, Weili Fu   +10 more
wiley   +1 more source

SENOLYTICS AND SENOMORPHICS: A NEW CLASS OF DRUGS FOR ANTI-AGING THERAPY

Central Asian Journal of Medical Hypotheses and Ethics
Aging is a complex biological process characterized by the accumulation of senescent cells that adopt a senescence-associated secretory phenotype (SASP), releasing proinflammatory mediators that drive tissue dysfunction and the onset of age-related ...
Timur Saliev, Prim B. Singh
doaj   +1 more source

Short-term sustained hyperglycaemia fosters an archetypal senescence-associated secretory phenotype in endothelial cells and macrophages

Redox Biology, 2018
Diabetic status is characterized by chronic low-grade inflammation and an increased burden of senescent cells. Recently, the senescence-associated secretory phenotype (SASP) has been suggested as a possible source of inflammatory factors in obesity ...
Francesco Prattichizzo, Valeria De Nigris, Elettra Mancuso, Rosangela Spiga, Angelica Giuliani, Giulia Matacchione, Raffaella Lazzarini, Fiorella Marcheselli, Rina Recchioni, Roberto Testa, Lucia La Sala, Maria Rita Rippo, Antonio Domenico Procopio, Fabiola Olivieri, Antonio Ceriello   +14 more
doaj   +1 more source