Results 71 to 80 of about 26,150 (274)

Whole Chromosome Instability induces senescence and promotes SASP [PDF]

Scientific Reports, 2016
Abstract Age-related accumulation of ploidy changes is associated with decreased expression of genes controlling chromosome segregation and cohesin functions. To determine the consequences of whole chromosome instability ( W-CIN ) we down-regulated the spindle assembly ...
Andriani, GA, Almeida, VP, Faggioli, F, Mauro, M, Tsai, WL, Santambrogio, L, Maslov, A, Gadina, M, Campisi, J, Vijg, J, Montagna, C   +10 more
openaire   +6 more sources

“Comparison of in vitro models for the study of senescence of macrophages associated with a tumor

Медицинская иммунология
Tumor-associated macrophages (TAMs) are an important and most represented population of immune cells in the tumor microenvironment. To a great extent, TAMs can determine the direction of the antitumor immune response; they can either additionally ...
T. V. Pukhalskaia, T. R. Yurakova, V. S. Mikhailovskaya, D. A. Bogdanova, O. N. Demidov   +4 more
doaj   +1 more source

Short-term sustained hyperglycaemia fosters an archetypal senescence-associated secretory phenotype in endothelial cells and macrophages

Redox Biology, 2018
Diabetic status is characterized by chronic low-grade inflammation and an increased burden of senescent cells. Recently, the senescence-associated secretory phenotype (SASP) has been suggested as a possible source of inflammatory factors in obesity ...
Francesco Prattichizzo, Valeria De Nigris, Elettra Mancuso, Rosangela Spiga, Angelica Giuliani, Giulia Matacchione, Raffaella Lazzarini, Fiorella Marcheselli, Rina Recchioni, Roberto Testa, Lucia La Sala, Maria Rita Rippo, Antonio Domenico Procopio, Fabiola Olivieri, Antonio Ceriello   +14 more
doaj   +1 more source

Isolation methodology is essential to the evaluation of the extracellular vesicle component of the senescence‐associated secretory phenotype

Journal of Extracellular Vesicles, 2021
A hallmark of senescence is the acquisition of an enhanced secretome comprising inflammatory mediators and tissue remodelling agents – the senescence‐associated secretory phenotype (SASP).
Ryan Wallis, Natasa Josipovic, Hannah Mizen, Arturo Robles‐Tenorio, Eleanor J. Tyler, Argyris Papantonis, Cleo L. Bishop   +6 more
doaj   +1 more source

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

Oxidative stress and senescence in aging kidneys

EXCLI Journal : Experimental and Clinical Sciences
Aging leads to a gradual decline in kidney function, making the kidneys increasingly vulnerable to various diseases. Oxidative stress, together with cellular senescence, has been established as paramount in promoting the aging process of the kidney ...
Waleed Hassan Almalki, Salem Salman Almujri   +1 more
doaj   +1 more source

Analysis of molecular subtypes and prognostic signature of senescence-associated secretory phenotype in pancreatic cancer [PDF]

PeerJ
Background Pancreatic cancer (PC) exhibits an extremely poor prognosis due to its high heterogeneity. The senescence-associated secretory phenotype (SASP), a distinct secretory profile displayed by senescent cells, has been increasingly studied. However,
Yuewen Kuang, Mingkun Jia, Yuming Zhu, Zhiyong Xiang   +3 more
doaj   +2 more sources

Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling

Nature Communications, 2023
Cellular senescence and associated secretory phenotype (SASP) are thought to contribute to aging and tissue dysfunction, though it is unclear how SASP impacts regeneration.
Jina Yun, Simon Hansen, Otto Morris, David T. Madden, Clare Peters Libeu, Arjun J. Kumar, Cameron Wehrfritz, Aaron H. Nile, Yingnan Zhang, Lijuan Zhou, Yuxin Liang, Zora Modrusan, Michelle B. Chen, Christopher C. Overall, David Garfield, Judith Campisi, Birgit Schilling, Rami N. Hannoush, Heinrich Jasper   +18 more
doaj   +1 more source

Shotgun proteomics reveals senomorphic targets based on SASP-mediated by small extracellular vesicles

, 2023
Poster.-- Human Proteome Organization World Congress, HUPO 2023, 17-21 SeptemberCells have the capacity to modulate the microenvironment through the secretion of molecules (cytokines, chemokines, matrix proteins…) and vesicles, which vary according to ...
Lucio-Gallego, Sergio, Carrera, Mónica, Mateos, Jesús, Gil, Concha, Arufe, María C., Gutiérrez, Lola, Mato-Basalo, Rocío, Fafián-Labora, Juan, Alarcón-Veleiro, Carmen   +8 more
core  

Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2. [PDF]

, 2015
Senescent cells show an altered secretome profile termed the senescence-associated secretory phenotype (SASP). There is an increasing body of evidence that suggests that the accumulation of SASP-positive senescent cells in humans is partially causal in ...
Talgat Nurgozhin, Faragher, Richard, Faragher, Richard G. A., Brook, Amy J.C., Zhaxybay Zhumadilov, Davis, Terence, Zhumadilov, Z., David Kipling, Nurgozhin, T., Lynne S. Cox, Amy J. C. Brook, Cox, Lynne S., Alimbetov, Dauren, Kipling, David Glyn, Dauren Alimbetov, Terence Davis, Zhumadilov, Zhaxybay, Nurgozhin, Talgat, Kipling, D., Brook, Amy J. C., Richard G. A. Faragher, Cox, Lynne, Richard Faragher   +22 more
core   +1 more source