Results 91 to 100 of about 22,235 (292)

Overcoming the senescence‐associated secretory phenotype (SASP): a complex mechanism of resistance in the treatment of cancer

, 2021
Senescence is a cellular state in which cells undergo persistent cell cycle arrest in response to nonlethal stress. In the treatment of cancer, senescence induction is a potent method of suppressing tumour cell proliferation.
Shona Ritchie, Brooke A. Pereira, Cecilia R. Chambers, Paul Timpson   +3 more
core   +1 more source

Advances in Gastric Cancer Research: Insights Into Carcinogenesis, the Tumor Microenvironment, Metastasis, and Factors Influencing Prognosis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background The Department of Gastroenterological Surgery at Kumamoto University has maintained a commitment to integrating cutting‐edge clinical practice with fundamental research, particularly concerning malignant diseases of the digestive tract.
Hideo Baba, Takatsugu Ishimoto, Yoshifumi Baba, Hiromitsu Hayashi, Masaaki Iwatsuki   +4 more
wiley   +1 more source

Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics

Advanced Intelligent Discovery, EarlyView.
A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha, Jesus Gil, Pedro J. Ballester   +2 more
wiley   +1 more source

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

Oral microbiome-SASP-aging axis: mechanisms and targeted intervention strategies for age-related diseases

Journal of Oral Microbiology
Background Global demographic aging is intensifying the burden of age-related diseases. Cellular senescence and the accompanying senescence-associated secretory phenotype (SASP) act as key drivers of disease progression by mediating chronic inflammation.
Enfang Wu, Xueyu Li, Zichen Ni, Feng Zhao, Chen Jia   +4 more
doaj   +1 more source

The Triumf Second Arm Spectrometer System (SASP)

, 1995
The Second Arm SPectrometer (SASP) is a 130 ton 769 M e V / c QQClamshell magnetic spectrometer which pivots at the T2 location on the beam line 4B, and operates simultaneously in a coincidence mode with the existing M R S spectrometer.
Chakhalyan, Jacques A.
core  

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Smart Nanodelivery Systems for Immunometabolic Modulation in Osteoarthritis

Exploration, EarlyView.
Smart nanodelivery systems deliver therapeutic payloads across the cartilage matrix to ensure their sustained accumulation within chondrocytes at sites of injury. By targeting specific molecular targets and signaling pathways, these platforms modulate the pathological synovium‐cartilage axis to restore immunometabolic homeostasis and drive tissue ...
Qirui Zhao, Zhewen Mi, Shuya Liu, Shijun Liang, Linjia Peng, Zixuan Gao, Jiaming Li, Xiaoqing Lu, Zhiguang Ren, Yongjie Wan, Shengsheng Cui, Longlong Lu, Xiaoyang Gao, Tao Wang, Hui Liang, Furong Tian, de la Fuente Jesus M, Chong Xiang, Luyi Sun, Lichen Xiang, Daxiang Cui   +20 more
wiley   +1 more source

Prognostic Significance and Biologic Associations of Senescence‐Associated Secretory Phenotype Biomarkers in Heart Failure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The role of cellular senescence in human heart failure (HF) remains unclear. The senescence‐associated secretory phenotype (SASP) is composed of proteins released by senescent cells.
Oday Salman, Payman Zamani, Lei Zhao, Marie Joe Dib, Sushrima Gan, Joe David Azzo, Bianca Pourmussa, Arthur Mark Richards, Ali Javaheri, Douglas L. Mann, Ernst Rietzschel, Manyun Zhao, Zhaoqing Wang, Christina Ebert, Laura Liu, Kushan L. Gunawardhana, Danielle Greenawalt, Leon Carayannopoulos, Ching‐Pin Chang, Vanessa van Empel, Joseph Gogain, Peter H. Schafer, David A. Gordon, Francisco Ramirez‐Valle, Thomas P. Cappola, Julio A. Chirinos   +25 more
doaj   +1 more source

Spectrum-aware shared protection (SASP) algorithm for cognitive radio networks

, 2018
Cognitive radio (CR) has become a key technology for addressing spectrum scarcity. In CR networks, spectrum access should not interfere the incumbent networks.
S. Esakki Rajavel, T. Aruna, S. Allwin Devaraj   +2 more
core   +1 more source