Results 91 to 100 of about 26,150 (274)

Orthogonal Light‐ and Enzyme‐Triggered and‐Gate Prodrugs for Senolytic Therapy

Advanced Science, EarlyView.
An orthogonal AND‐gate prodrug platform combines 390 nm near‐UV photocleavage with SA‐β‐gal activation to control payload release in senescent cells. Its modular architecture enables 4‐MU fluorescence, doxorubicin‐mediated cytotoxicity, and ARV‐771‐driven BRD4 degradation, supporting stimulus‐controlled senolytic design in cellular and organoid models.
Mengyang Chang, Kaixue Zhang, Junwei Wang, Fangchao Bi, Zhuoxin Dai, Miao Yang, Ming Liu, Huanzhi Peng, Franklin Zhang, Yuan Guo, Jigang Dai, Quanxing Liu, Wei Wang   +12 more
wiley   +1 more source

Pharmacokinetics of Salazosulfapyridine (Sulfasalazine, SASP). V. Pharmacokinetics of SASP after a single intravenous or oral administration in the dog.

Drug Metabolism and Pharmacokinetics, 1991
Salazosulfapyridine(Sulfasalazine, SASP) labelled with 14C in the carboxyl group and with 3H in the benzenesulfonyl ring was administered intravenously or orally to male and female beagle dogs with and without bile fistulas in order to study the pharmacokinetics.
SJÖQUIST, Birgitta, AHNFELT, Nils-Otto, ANDERSSON, Stig, d'ARGY, Roland, FJELLNER, Gunnar, HATSUOKA, Masanori, LJUNGSTEDT-PÅHLMAN, Ingrid   +6 more
openaire   +2 more sources

Inactivation of TFEB and NF-κB by marchantin M alleviates the chemotherapy-driven pro-tumorigenic senescent secretion

Acta Pharmaceutica Sinica B, 2019
It is critical to regulate the senescence-associated secretory phenotype (SASP) due to its effect on promoting malignant phenotypes and limiting the efficiency of cancer therapy.
Huanmin Niu, Lilin Qian, Bin Sun, Wenjian Liu, Fang Wang, Qian Wang, Xiaotian Ji, Yanhai Luo, Effat Un Nesa, Hongxiang Lou, Huiqing Yuan   +10 more
doaj   +1 more source

Progression of irradiated mesenchymal stromal cells from early to late senescence: Changes in SASP composition and anti-tumour properties

, 2023
: Genotoxic injuries converge on senescence-executive program that promotes production of a senescence-specific secretome (SASP). The study of SASP is particularly intriguing, since through it a senescence process, triggered in a few cells, can spread to
Squillaro, Tiziana, Servet Özcan, Alessio, Nicola, Gianfranco Peluso, Peluso, Gianfranco, Galderisi, Umberto, Aprile, Domenico, Tiziana Squillaro, Şerife Ayaz‐Güner, Umberto Galderisi, Giovanni Di Bernardo, Acar, Mustafa Burak, Domenico Aprile, Ayaz‐Güner, Şerife, Ayaz-Güner, Şerife, Di Bernardo, Giovanni, Özcan, Servet, Mustafa Burak Acar, Nicola Alessio, 7. Özcan, Servet, 9. Ayaz-Güner, Şerife, 4. Aprile, Domenico, 3. Squillaro, Tiziana, 8. Galderisi, Umberto, 6. Di Bernardo, Giovanni, 2. Acar, Mustafa Burak, 1. Alessio, Nicola, 5. Ayaz Güner, Şerife   +27 more
core   +1 more source

A Dual‐Functional Nanoplatform Targeting the dsDNA–cGAS Axis to Mitigate Disc Degeneration and Aberrant Innervation

Advanced Science, EarlyView.
RU@PEI‐ZIF integrates dsDNA scavenging with local cGAS inhibition to suppress the dsDNA–cGAS–STING/Netrin‐1 axis in intervertebral disc degeneration. By attenuating nucleus pulposus cell senescence, inflammatory and matrix‐catabolic responses, and pathological sensory innervation, this dual‐functional nanoplatform preserves disc integrity and reduces ...
Zhaojun He, Tianyu Chen, Zezheng Liu, Xinlin Huang, Ruitangbin Jiang, Yihao Liu, Baojing Xu, Yuxiang Li, Kangning Zhao, Huibo Yan, Lei Zhou, Can Liu, Qingchu Li   +12 more
wiley   +1 more source

Mn/Zn Bimetallic MOF‐Integrated Hydrogel Alleviates Excessive Mitochondrial Fission in BMSCs to Promote Osteoporotic Jawbone Repair

Advanced Science, EarlyView.
Excessive reactive oxygen species (ROS) and chronic inflammation impair bone marrow‐derived mesenchymal stem cells (BMSCs), contributing to poor healing in osteoporotic jawbone defect. The gelatin methacryloyl hydrogel loaded with manganese‐doped zeolitic imidazolate framework (Mn‐ZIF‐8@GelMA) promotes regeneration through redox regulation and ...
Xiayue Jin, Shengjia Ye, Yun Yuan, Xueying Yang, Jiarui Cui, Hongming Zhang, Hui Huang   +6 more
wiley   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

Oral microbiome-SASP-aging axis: mechanisms and targeted intervention strategies for age-related diseases

Journal of Oral Microbiology
Background Global demographic aging is intensifying the burden of age-related diseases. Cellular senescence and the accompanying senescence-associated secretory phenotype (SASP) act as key drivers of disease progression by mediating chronic inflammation.
Enfang Wu, Xueyu Li, Zichen Ni, Feng Zhao, Chen Jia   +4 more
doaj   +1 more source

LncRNA FLJ20021 Restrains Fibroblast Senescence and Matrix Remodeling in Pelvic Organ Prolapse by Promoting XRCC6‐Dependent ADI1 Transcription

Advanced Science, EarlyView.
FLJ20021 interacts with XRCC6 to regulate ADI1 transcription and downstream cellular phenotypes in hUSLFs. Reduced FLJ20021 in POP is associated with lower ADI1, increased apoptosis, senescence, and an ECM‐degrading marker profile. Conversely, FLJ20021 overexpression enhances XRCC6‐dependent ADI1 expression, reduces apoptosis and senescence, and shifts
YanFeng Yang, BingJie Rui, GuangHai Rui, YiNan Duan, Ji Hyang Kim   +4 more
wiley   +1 more source

Long‐Term Expandable Periosteal Organoids Reconstruct a Functional Regenerative Niche That Support Hematopoietic Stem Cell Maintenance and Bone Repair

Advanced Science, EarlyView.
A robust periosteal organoid system enables long‐term expansion while preserving native cellular heterogeneity. These organoids recapitulate functional niche environments, support hematopoietic stem cell maintenance, and attenuate aging‐associated decline ex vivo.
Jia Qing, Lanxin Gu, Lipeng Fu, Xin Gao, Zechuan Li, Hui Zhang, Wenpeng Song, Huixin Lv, Yongsheng Zhou, Ping Zhang   +9 more
wiley   +1 more source