Results 111 to 120 of about 30,415 (217)

α-Lipoic acid alleviate myocardial infarction by suppressing age-independent macrophage senescence

Scientific Reports
Myocardial infarction (MI) has high morbidity and mortality, and the macrophage senescence-associated secretory phenotype (SASP) plays a central role in M1 healing. α-Lipoic acid (ALA) alleviates MI by regulating the function of macrophages, although the
Yuchao Wang, Yue Zheng, Xiaoyu Liang, Yun Chang, Yanwu Liu, Xian Cheng, Meng Zhang, Wenqing Gao, Tong Li   +8 more
doaj   +1 more source

Partially-Latent Class Models (pLCM) for Case-Control Studies of Childhood Pneumonia Etiology [PDF]

, 2014
In population studies on the etiology of disease, one goal is the estimation of the fraction of cases attributable to each of several causes. For example, pneumonia is a clinical diagnosis of lung infection that may be caused by viral, bacterial, fungal,
Deloria-Knoll, Maria, Hammitt, Laura L., Wu, Zhenke, Zeger, Scott L.   +3 more
core   +2 more sources

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Profiling with senescence-associated secretory phenotype score identifies GDC-0879 as a small molecule sensitizing glioblastoma to anti-PD1

Cell Death and Disease
Senescence-associated secretory phenotype (SASP) in cancer refers to the bioactive secretome produced by senescence cells in the tumor microenvironment, which could be triggered by therapeutics or local stress conditions.
Yang Liu, Yuan Feng, Lin Cheng, Yangxi Xu, Anhua Wu, Peng Cheng   +5 more
doaj   +1 more source

SASP Modulation for Cellular Rejuvenation and Tissue Homeostasis: Therapeutic Strategies and Molecular Insights

Cells
Cellular senescence regulates aging, tissue maintenance, and disease progression through the Senescence-Associated Secretory Phenotype (SASP), a secretory profile of cytokines, chemokines, growth factors, and matrix-remodeling enzymes.
Saud Alqahtani, Taha Alqahtani, Krishnaraju Venkatesan, Durgaramani Sivadasan, Rehab Ahmed, Nizar Sirag, Hassabelrasoul Elfadil, Hanem Abdullah Mohamed, Haseena T.A., Rasha Elsayed Ahmed, Pooja Muralidharan, Premalatha Paulsamy   +11 more
doaj   +1 more source

The Role of Wnt Signaling in Age‐Related Alveolar Bone Loss and Regeneration

Journal of Periodontal Research, EarlyView.
The graphical abstract summarizes key signaling pathways involved in bone formation and resorption associated with Wnt signaling across young and aged long bone and jaw tissues. Levels of evidence are indicated as robust, moderate, or emerging, reflecting the current experimental support in each context.
Hsiao H. Sung, Navya Chalamalasetty, Ali Alzainal, Hanlong Liu, Lexuan Wang, Pietra Colacrai Arikita, Ivy C. X. Wei, Hom‐Lay Wang, M. H. J. van den Bosch, Michelle S. Caird, Peter M. van der Kraan, Kenneth M. Kozloff, Esmeralda Blaney Davidson   +12 more
wiley   +1 more source

Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature

European Journal of Medical Research
The senescence-associated secretory phenotype (SASP) is a generic term for the secretion of cytokines, such as pro-inflammatory factors and proteases. It is a crucial feature of senescent cells.
Shangkun Zhao, Zhi Qiao, Roman Pfeifer, Hans-Christoph Pape, Keya Mao, Hai Tang, Bin Meng, Songfeng Chen, Hongjian Liu   +8 more
doaj   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

The protective effects of vitamin E and C against oxidative stress induced by sulfasalazine in the testis of male adult rats [PDF]

Journal of Advanced Biomedical Sciences, 2011
Background & Objective: Sulfasalazine (SASP) is a drug used for the treatment of inflammatory bowel diseases. SASP causes testicular damage. The aim of this study was to verify whether or not an additional supply of vitamin E or C or together prevent the
Mojbaba Keshavars, Mohammad Ali Takhshid, Alireza Tavasoli, Hossein Kargar Jahromi, Mohammad Hasan Meshkibaf, Yazdan Heydari   +5 more
doaj  

c-Myb and C/EBPβ regulate OPN and other senescence-associated secretory phenotype factors [PDF]

, 2017
Alspach, Elise, Arthur, Laura L, Flanagan, Kevin C, Parajuli, Shankar, Pazolli, Ermira, Ren, Qihao, Stewart, Sheila A, Tapia, Roberto   +7 more
core   +2 more sources