Results 111 to 120 of about 26,150 (274)

Characterizing the SASP ‐Dependent Paracrine Spreading of Senescence Between Human Brain Cell Types

One of the defining phenotypes of a senescent cell is the senescence‐associated secretory phenotype (SASP), which can propagate senescence in neighboring cells both in vitro and in vivo.
Markus Riessland, Taylor Russo
core   +1 more source

Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics

Advanced Intelligent Discovery, EarlyView.
A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha, Jesus Gil, Pedro J. Ballester   +2 more
wiley   +1 more source

Biomimetic Nanomedicine for Aging‐Impaired Bone Regeneration: From Microenvironmental Dysfunction to Precision Therapeutics

Advanced NanoBiomed Research, EarlyView.
Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang, He Zhang, Simo Liu, Rui Wang, Yiran Wei, Kailu Zheng, Yanming Guo, Min Li, Dian Yuan, Yuxin Liu, Lifang Feng, Yongping Ma, Yan Liu   +12 more
wiley   +1 more source

MDL‐800–Induced Sirtuin 6 Activation Decreases Age‐Associated Osteoarthritis in Mice

Arthritis &Rheumatology, EarlyView.
Objective Sirtuin 6 (SIRT6) is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of MDL‐800, a small molecule activator of SIRT6, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez, Pranay Ramteke, Bahiyah Watson, Owen Haslam, Eirene Choi, Susan Chubinskaya, Mandy J. Peffers, William R. Davis, Jacqueline Shine, Brian O. Diekman, Richard F. Loeser, Theresa A. Freeman, Makarand V. Risbud, John A. Collins   +13 more
wiley   +1 more source

Cardiac Rehab / SASP - Cardiac Exercise Programme

Cardiac Rehab / SASP - Cardiac Exercise Programme CC BY-NC-ND 4.0Cardiac Rehab / SASP - Cardiac Exercise ...
Tom MacConnell
core  

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

A phosphorylation switch in the Mediator MED15 controls cellular senescence and cognitive decline

Cell Discovery
A hallmark of aging is chronic systemic inflammation, which is exacerbated by the hypersecretory aging phenotype known as the senescence-associated secretory phenotype (SASP).
Haozheng Li, Yuanming Zheng, Chunlei Yuan, Jiayi Wang, Xiaying Zhao, Ming Yang, Defei Xiong, Yenan Yang, Yunpeng Dai, Yiming Gao, Yuqi Wang, Lei Xue, Gang Wang   +12 more
doaj   +1 more source

Cellular Senescence and the SASP in HFpEF: Pathogenic Mechanisms and Therapeutic Targeting

Heart failure with preserved ejection fraction (HFpEF) represents a complex syndrome strongly associated with aging, characterized by diastolic dysfunction, myocardial stiffness, and chronic low-grade inflammation.
Yan Tu, Hao Zhang, Qiu-Cheng Zhu, Xiang-Jie Liu, Qiong Zheng, Ping Wang   +5 more
core   +1 more source

The womb as the cradle of longevity: Perinatal origins of biological aging

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract The perinatal period is increasingly recognized as an important determinant of biological aging trajectories and disease susceptibility across the lifespan. This narrative review synthesizes current evidence linking intrauterine exposures to adult health outcomes across three biological dimensions: fetal programming, maternal influences, and ...
Sevim Ozge Ozdemir, Ebru Davutoglu
wiley   +1 more source

Isolation and identification of Lom-SG-SASP, a salivation stimulating peptide from the salivary glands of Locusta migratoria

, 1995
From a methanolic extract of about 2500 salivary glands of Locusta migratoria a peptide was isolated which stimulates cAMP production in the salivary glands and salivation. Maldi-TOFMS revealed a mass of 1779 Da.
Schoofs, Liliane, Van Beeumen, J., Veelaert, Dirk, Devreese, B., Jo Van Damme, Proost, Paul, Van Damme, Jozef, Dirk Veelaert, Paul Proost, Arnold De Loof, Bart Devreese, De Loof, Arnold, Liliane Schoofs, Jozef Van Beeumen   +13 more
core   +1 more source