Results 101 to 110 of about 26,150 (274)

Role of Senescence-Associated Biomarkers and Immune Dynamics in Predicting Response to Neoadjuvant Chemoradiotherapy in Rectal Cancer

International Journal of General Medicine
Yandong Liu, Chenchen Wu, Xiao Lu, Jiao Xue Department of Radiotherapy, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, 215123, People’s Republic of ChinaCorrespondence: Jiao Xue, Email szxuejiao@163.comObjective:
Liu Y, Wu C, Lu X, Xue J
doaj  

Prognostic Significance and Biologic Associations of Senescence‐Associated Secretory Phenotype Biomarkers in Heart Failure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The role of cellular senescence in human heart failure (HF) remains unclear. The senescence‐associated secretory phenotype (SASP) is composed of proteins released by senescent cells.
Oday Salman, Payman Zamani, Lei Zhao, Marie Joe Dib, Sushrima Gan, Joe David Azzo, Bianca Pourmussa, Arthur Mark Richards, Ali Javaheri, Douglas L. Mann, Ernst Rietzschel, Manyun Zhao, Zhaoqing Wang, Christina Ebert, Laura Liu, Kushan L. Gunawardhana, Danielle Greenawalt, Leon Carayannopoulos, Ching‐Pin Chang, Vanessa van Empel, Joseph Gogain, Peter H. Schafer, David A. Gordon, Francisco Ramirez‐Valle, Thomas P. Cappola, Julio A. Chirinos   +25 more
doaj   +1 more source

Donor‐Cell Senescence Redirects PINK1‐Marked Mitochondrial Cargo From Mitophagy to Microvesicle Transfer Through SUMO3‐Stabilized HSPA9

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicle therapies have been developed for tissue repair, but how donor‐cell senescence reshapes vesicle‐mediated mitochondrial transfer remains unclear. Here, we show that senescent adipose‐derived stem cells (ADSCs) redirect damaged mitochondria into microvesicles (MVs), converting protective vesicles into pro‐degenerative ...
Zixuan Ou, Mingke Zhao, Zhiwei Ling, Lianqi Peng, Bide Tong, Huaizhen Liang, Hongchuan Wang, Di Wu, Yifan Du, Zhi Du, Shihao Zhang, Yuyuan Jia, Yifan Qian, Gan Xu, Liuliang He, Gang Li, Shun Zhang, Lei Tan, Kun Wang, Xiaobo Feng, Cao Yang, Zhiwei Liao   +21 more
wiley   +1 more source

Senescent Mesenchymal Stromal Cells Drive Stem Cell Aging Through Dysregulated Chemokine Synthesis. [PDF]

Aging Cell
Senescent MSCs do more than fuel inflammaging: they disrupt the chemokine signals that maintain stem cell function. We propose that restoring this signaling balance through senolytics, senomorphics, or MSC rejuvenation may preserve regenerative capacity during aging. ABSTRACT Aging is accompanied by a progressive decline in tissue regenerative capacity,
Stein SN, Braid LR.
europepmc   +2 more sources

Lithium‐Doped Hydroxyapatite Nanowires Rejuvenate Senescent Macrophages Via the Lysosome‐Dependent Ferroptosis Axis to Promote Aged Bone Regeneration

Advanced Science, EarlyView.
Li‐nHAP+GelMA promotes mandibular bone regeneration in aged mice by remodeling the senescent immune microenvironment. Local delivery of Li‐nHAP restores lysosomal homeostasis in senescent macrophages, reduces intracellular labile Fe2+ accumulation, ROS production, and lipid peroxidation, thereby suppressing macrophage ferroptosis and senescence ...
Baixi Chen, Ziduan Ding, Ruomei Li, Cheng Zhu, Zhiyu Zhu, Zitong Yang, Luyao Qu, Jin Hao, Lunguo Xia, Bing Fang, Lu Liu   +10 more
wiley   +1 more source

A Bi‐Adjuvant Senolytic Nanovaccine Modulating Dendritic Cell Senescence Ameliorates Aging‐Related Metabolic Dysfunction

Advanced Science, EarlyView.
An active biomaterial‐based bi‐adjuvant nanovaccine restores the immunocompetence of aged dendritic cells to overcome senescent cell tolerance. Accompanied by the downregulation of mitotic kinases Aurka/b and attenuation of senescence‐associated PI3K/AKT phosphorylation, the nanovaccine enhances antigen‐presenting capacity and promotes potent cytotoxic
Qingxu Song, Xiaoxue Du, Wenbo Dong, Ying Wang, Xiaojing Wang, Qiliang Yin   +5 more
wiley   +1 more source

The Triumf Second Arm Spectrometer System (SASP)

, 1995
The Second Arm SPectrometer (SASP) is a 130 ton 769 M e V / c QQClamshell magnetic spectrometer which pivots at the T2 location on the beam line 4B, and operates simultaneously in a coincidence mode with the existing M R S spectrometer.
Chakhalyan, Jacques A.
core   +1 more source

Simultaneous Inhibition of Histone Deacetylases and EZH2 Reduces SASP in Non-Small Cell Lung Cancer

Background: Cellular senescence, a common outcome of treatments like chemotherapy and radiotherapy, often acts as a therapeutic hurdle. Our prior investigations revealed that this senescent state is accompanied by the secretion of the senescence ...
Pak, CholJin Pak
core   +1 more source

PHGDH‐Mediated Serine Metabolism in Nucleus Pulposus Cells Is a Potential Therapeutic Target for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
When nucleus pulposus cells senesce, PHGDH decreases, reducing serine synthesis and glutathione, impairing antioxidant capacity. The intermediate α‐KG also drops, lowering JMJD3 demethylase activity, increasing H3K27me3 at the Rap1b promoter, and reducing Rap1b expression, whose down‐regulation in turn activates mTORC1 and suppresses autophagy ...
Hao‐Wei Xu, Sheng‐Jie Chang, Xiao‐Wei Liu, Shu‐Bao Zhang, Ying‐Jie Wang, Shan‐Jin Wang   +5 more
wiley   +1 more source

Leptin Neutralization Attenuates Inflammaging in Endothelial and Immune Cell Models. [PDF]

MedComm (2020)
Multiple mechanisms including senescent cell accumulation, metabolic and endotoxin‐driven stimulation of immune and endothelial cells contribute to inflammaging, the chronic low‐grade inflammatory status underlying age‐related diseases. Blocking leptin signaling in experimental models of inflammaging blunts inflammation in a model‐specific manner while
Pellegrini V, La Grotta R, Metallo A, Carreras F, Frigé C, Matacchione G, Giuliani A, Sabbatinelli J, Olivieri F, Rispoli F, Drago L, Berra CC, Marfella R, Paolisso G, Matarese G, Procaccini C, Spatocco I, Mele G, de Candia P, Ceriello A, Prattichizzo F.   +20 more
europepmc   +2 more sources