Results 101 to 110 of about 30,415 (217)

A phosphorylation switch in the Mediator MED15 controls cellular senescence and cognitive decline

Cell Discovery
A hallmark of aging is chronic systemic inflammation, which is exacerbated by the hypersecretory aging phenotype known as the senescence-associated secretory phenotype (SASP).
Haozheng Li, Yuanming Zheng, Chunlei Yuan, Jiayi Wang, Xiaying Zhao, Ming Yang, Defei Xiong, Yenan Yang, Yunpeng Dai, Yiming Gao, Yuqi Wang, Lei Xue, Gang Wang   +12 more
doaj   +1 more source

Finite element analysis of a deployable space structure [PDF]

, 1982
To assess the dynamic characteristics of a deployable space truss, a finite element model of the Scientific Applications Space Platform (SASP) truss has been formulated.
Hutton, D. V.
core   +1 more source

1H NMR metabolomics and lipidomics analysis of neutrophils reveals biomarkers of ageing, inflammageing and frailty

The FEBS Journal, EarlyView.
Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah, Grace Filbertine, Lucy Gill, Asangaedem Akpan, Marie M. Phelan, Helen Louise Wright   +5 more
wiley   +1 more source

Co‐pathologies and biological processes beyond amyloid‐beta and tau in people with Alzheimer's disease: Evidence from clinical cohort studies

Journal of Internal Medicine, EarlyView.
Abstract Alzheimer's disease (AD) is neuropathologically defined by amyloid‐beta (Aβ) plaques and tau neurofibrillary tangles. However, co‐pathologies and other pathobiological processes are involved in the pathogenesis of AD, contributing to neurodegeneration and clinical symptoms.
Daniel Ferreira, Tomasz Chmiela, Maria Eriksdotter, Clifford R. Jack Jr., Grégoria Kalpouzos, Anna Marseglia, Patrizia Mecocci, Agneta Nordberg, Dorota Religa, Eric Westman   +9 more
wiley   +1 more source

Mitochondrial RNA cytosolic leakage drives the SASP

Nature Communications
Senescent cells secrete proinflammatory factors known as the senescence-associated secretory phenotype (SASP), contributing to tissue dysfunction and aging. Mitochondrial dysfunction is a key feature of senescence, influencing SASP via mitochondrial DNA (
Stella Victorelli, Madeline Eppard, Hélène Martini, Seung-Hwa Woo, Stacia P. A. Everts, Gung Lee, Nicholas Pirius, Nuan Han, Eugene Y. Liang, Ana Catarina Franco, Yeaeun Han, Dominik Saul, Eva Nóvoa, Rubén Nogueiras, Patrick L. Splinter, Steven P. O’Hara, Olivia Morgenthaler, Lucía Valenzuela-Pérez, Hyun Se Kim Lee, Diana Jurk, Nicholas F. LaRusso, Petra Hirsova, João F. Passos   +22 more
doaj   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Groeger Sabine Elisabeth, Zhou Yuxi, Yong Jiawen, Wang Lei, Ruf Sabine, Meyle Joerg   +5 more
wiley   +1 more source

Mechanism of action of 5-arninosalicylic acid

Mediators of Inflammation, 1992
5-Aminosalicylic Acid (5-ASA) has been used for over 50 years in the treatment of inflammatory bowel disease in the pro-drug form sulphasalazine (SASP). SASP is also used to treat rheumatoid arthritis.
N. A. Punchard, S. M. Greenfield, R. P. H. Thompson   +2 more
doaj   +1 more source

Mitochondria, telomeres and cell senescence: Implications for lung ageing and disease

, 2017
Cellular senescence, the irreversible loss of replicative capacity in somatic cells, plays a causal role in the development of age-related pathology and in a number of age-related chronic inflammatory diseases.
Barnes, PJ, Birch, J, Passos, JF
core   +1 more source

Drug‐induced hypersensitivity syndrome followed by exacerbation of Crohn's disease

Pediatric Investigation, EarlyView.
Mei Kamidani, Ryo Tanaka, Hiroshi Oue, Risa Fukuda, Rena Hashimoto, Ichiro Takeuchi, Takako Yoshioka, Naoya Tonegawa, Akira Ishiguro, Katsuhiro Arai, Kazue Yoshida   +10 more
wiley   +1 more source

Inflammation Affects the Osteogenic Differentiation of Aged Periodontal Ligament Cells via NF‐κB/FOXO3a/c‐JUN Signalling

Journal of Periodontal Research, EarlyView.
NF‐κB/FOXO3a/c‐JUN pathway plays a crucial role in osteogenic. Differentiation of aged PDLCs in an inflammatory microenvironment, although the mechanisms of this pathway differ in cellular ageing and pathological inflammation. ABSTRACT Aim This study aims to investigate the effect of inflammation on the senescence phenotype and osteogenic capacity of ...
Luying Zhu, Zhongyuan Tang, Renjie Hu, Yaxin Li, Xuan Li, Min Gu, Yanqi Yang   +6 more
wiley   +1 more source