Results 101 to 110 of about 22,235 (292)

Immune Checkpoint Inhibitors Induce Intestinal Epithelial Injury and a Senescence‐Like Phenotype

iNew Medicine, EarlyView.
ICI treatment promotes the infiltration of activated immune cells into the intestinal mucosa. This inflammatory microenvironment is associated with significant epithelial injury, characterized by the disruption of the epithelial barrier, the depletion of specialized secretory cell lineages, and the induction of a premature senescence phenotype ...
Juan Wang, Shuang Wu, Shuangbiao Wei, Weizhen Xiang, Jianshang Huang, Lei Xiong, Hua Wang, Li Zuo   +7 more
wiley   +1 more source

Modulation of Gut Microbiome Composition and Function in Experimental Colitis Treated with Sulfasalazine

Frontiers in Microbiology, 2017
Inflammatory bowel disease (IBD) results from alterations in intestinal flora and the immune system. Sulfasalazine (SASP) is a sulfa antimicrobial used to treat IBD in clinic for years.
Haihui Zheng, Mingyi Chen, Yuan Li, Yuanyuan Wang, Lin Wei, Ziqiong Liao, Mengxia Wang, Fangli Ma, Qiongfeng Liao, Zhiyong Xie   +9 more
doaj   +1 more source

Table1_Metformin mitigates SASP secretion and LPS-triggered hyper-inflammation in Doxorubicin-induced senescent endothelial cells.DOCX

, 2023
Introduction: Doxorubicin (DOX), a chemotherapeutic drug, induces senescence and increases the secretion of senescence-associated secretory phenotype (SASP) in endothelial cells (ECs), which contributes to DOX-induced inflammaging.
Kevin Agostinucci (12291407), Beshay N. Zordoky, Ibrahim Y. Abdelgawad (6383663), Marianne K. O. Grant, Beshay N. Zordoky (9105987), Kevin Agostinucci, Marianne K. O. Grant (9105981), Bushra Sadaf (15344248), Bushra Sadaf, Ibrahim Y. Abdelgawad   +9 more
core   +1 more source

Advances in Fluorescent Probes Targeting Senescence‐Associated β‐Galactosidase for Senescence Imaging

iRADIOLOGY, EarlyView.
Senescence‐associated β‐galactosidase fluorescent probes enable sensitive visualization of cellular senescence through turn‐on, ratiometric, aggregation‐induced emission‐active, and nanoprobe strategies. ABSTRACT Aging is a systemic biological process that spans multiple levels, including molecules, cells, tissues, and organs.
Jiahui Wang, Jun Wang, Shu Gao, Kun Qian, Qihang Ding, Zhen Cheng   +5 more
wiley   +1 more source

Role of Senescence-Associated Biomarkers and Immune Dynamics in Predicting Response to Neoadjuvant Chemoradiotherapy in Rectal Cancer

International Journal of General Medicine
Yandong Liu, Chenchen Wu, Xiao Lu, Jiao Xue Department of Radiotherapy, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, 215123, People’s Republic of ChinaCorrespondence: Jiao Xue, Email szxuejiao@163.comObjective:
Liu Y, Wu C, Lu X, Xue J
doaj  

Simultaneous Inhibition of Histone Deacetylases and EZH2 Reduces SASP in Non-Small Cell Lung Cancer

Background: Cellular senescence, a common outcome of treatments like chemotherapy and radiotherapy, often acts as a therapeutic hurdle. Our prior investigations revealed that this senescent state is accompanied by the secretion of the senescence ...
Pak, CholJin Pak
core   +1 more source

Dasatinib and quercetin prevent alveolar bone loss in aged mice

Journal of Periodontology, EarlyView.
Abstract Background Recent findings have associated alveolar bone loss (ABL) with the presence of senescent cells. Aging and the accumulation of senescent cells are associated with a pro‐inflammatory environment which may exacerbate tissue damage.
Luisa S. Battistelli, Renata M. Moraes, Yuri C. Santos, Jaqueline L. Ribeiro, Maíra T. Garcia, Renata F. Prado, Florent Elefteriou, Ana Lia Anbinder   +7 more
wiley   +1 more source

Aging and periodontitis increase brain dissemination of oral bacteria

Journal of Periodontology, EarlyView.
Abstract Background The microbiome is a dynamic system that changes throughout life. Studies have revealed the relationship between periodontal disease and the oral microbiota; however, the impact of periodontal disease on the expression of senescence markers and on the inflammaging of the oral and systemic microbiome remains unclear.
Ozge Unlu, Tsute Chen, Nil Yakar, Zeliha Guney, Bruce Paster, Isabel Carreras, Alpaslan Dedeoglu, Alpdogan Kantarci   +7 more
wiley   +1 more source

Regulation of senescence and the SASP by the transcription factor C/EBPβ

Experimental Gerontology, 2019
Oncogene-induced senescence (OIS) serves as an important barrier to tumor progression in cells that have acquired activating mutations in RAS and other oncogenes. Senescent cells also produce a secretome known as the senescence-associated secretory phenotype (SASP) that includes pro-inflammatory cytokines and chemokines.
Jacqueline, Salotti, Peter F, Johnson
openaire   +2 more sources

Osteoarthritis: An Immuno‐Inflammatory Disease‐Mechanisms of Immune Cell Dysregulation and Potential Therapeutic Strategies

Med Research, EarlyView.
This review summarizes the immuno‐inflammatory mechanisms driving the pathogenesis of osteoarthritis (OA), extending beyond the traditional view of OA as a purely degenerative disease to incorporate immune cell infiltration, inflammatory factor release, and the formation of a chronic low‐grade inflammatory microenvironment.
Qingqiang Lei, Xiaoxian Lou, Xu Su, Shubao Liu, Yanli Tong, Jie Chen, Xuerui Chen, Wenjun Mao, Hui Yu, Liangbin Lin   +9 more
wiley   +1 more source