Results 121 to 130 of about 22,235 (292)

Targeting hexokinase 2 to induce breast cancer cell senescence

British Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof, Katarina Cisarova, Sandra Burgstaller, Mia Schwerer, Markus Absenger‐Novak, Philipp J. Jost, Roland Malli, Wolfgang F. Graier, Robert Lukowski   +8 more
wiley   +1 more source

α-Lipoic acid alleviate myocardial infarction by suppressing age-independent macrophage senescence

Scientific Reports
Myocardial infarction (MI) has high morbidity and mortality, and the macrophage senescence-associated secretory phenotype (SASP) plays a central role in M1 healing. α-Lipoic acid (ALA) alleviates MI by regulating the function of macrophages, although the
Yuchao Wang, Yue Zheng, Xiaoyu Liang, Yun Chang, Yanwu Liu, Xian Cheng, Meng Zhang, Wenqing Gao, Tong Li   +8 more
doaj   +1 more source

Mechanism of action of 5-arninosalicylic acid

Mediators of Inflammation, 1992
5-Aminosalicylic Acid (5-ASA) has been used for over 50 years in the treatment of inflammatory bowel disease in the pro-drug form sulphasalazine (SASP). SASP is also used to treat rheumatoid arthritis.
N. A. Punchard, S. M. Greenfield, R. P. H. Thompson   +2 more
doaj   +1 more source

Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2.

, 2015
Senescent cells show an altered secretome profile termed the senescence-associated secretory phenotype (SASP). There is an increasing body of evidence that suggests that the accumulation of SASP-positive senescent cells in humans is partially causal in ...
Zhumadilov, Z, Talgat Nurgozhin, Nurgozhin, T, Faragher, Richard, Faragher, RGA, Kipling, D, Faragher, Richard G. A., Brook, Amy J.C., Zhaxybay Zhumadilov, Davis, Terence, Zhumadilov, Z., David Kipling, Kipling, David, Alimbetov, D, Nurgozhin, T., Lynne S. Cox, Faragher, Richard G.A., Amy J. C. Brook, Cox, Lynne S., Alimbetov, Dauren, Kipling, David Glyn, Dauren Alimbetov, Terence Davis, Zhumadilov, Zhaxybay, Nurgozhin, Talgat, Kipling, D., Brook, Amy J. C., Davis, T, Brook, AJC, Richard G. A. Faragher, Cox, LS, Cox, Lynne   +31 more
core   +1 more source

AMPK‐mediated prevention of vascular dysfunction with metformin: Experimental and population‐based evidence

British Journal of Pharmacology, EarlyView.
Angiotensin II induces vascular inflammation, senescence, extracellular matrix (ECM) degradation and endothelial dysfunction, thus impairing SK+/IK+ channel function and reducing endothelial‐dependent hyperpolarisation (EDH). Metformin activates AMPK, increasing SK+/IK+ channel function and restoring vasorelaxation.
Soroush Mohammadi Jouabadi, Annika A. Jüttner, Annique Claringbould, Rene de Vries, Ingrid M. Garrelds, Usha Musterd‐Bhaggoe, Bruno H. Stricker, Maryam Kavousi, A. H. Jan Danser, Fariba Ahmadizar, Anton J. M. Roks   +10 more
wiley   +1 more source

Profiling with senescence-associated secretory phenotype score identifies GDC-0879 as a small molecule sensitizing glioblastoma to anti-PD1

Cell Death and Disease
Senescence-associated secretory phenotype (SASP) in cancer refers to the bioactive secretome produced by senescence cells in the tumor microenvironment, which could be triggered by therapeutics or local stress conditions.
Yang Liu, Yuan Feng, Lin Cheng, Yangxi Xu, Anhua Wu, Peng Cheng   +5 more
doaj   +1 more source

Variable Expression of Oncogene-Induced Senescence/SASP Surrogates in HPV-Associated Precancerous Cervical Tissue

Oncogene-induced senescence (OIS) is a form of cellular senescence triggered by oncogenic signaling and, potentially, by infection with oncogenic viruses.
Ala’ Abu Ghalioun, Kholoud Friehat, Mohammed El-Sadoni, Bayan Shawish, Sofian Al Shboul, Anas Abu-Humaidan, Amani Al Rousan, Ahmad Alhesa, Nisreen Himsawi, Nisreen Abu Shahin, Moureq R. Alotaibi, Ola Abu Al Karsaneh, Ashraf I. Khasawneh, Rame Khasawneh, Tareq Saleh, Suzan Khawaldeh   +15 more
core   +1 more source

Mutational Signature‐Based Biomarker for Phase II Trial of Olaparib Maintenance in Advanced High‐Grade Ovarian Cancer

Cancer Science, EarlyView.
A whole‐exome sequencing–based mutational signature biomarker (MSBM) identified an HRD‐enriched population in advanced ovarian cancer. In a phase II trial, olaparib maintenance suggested clinically meaningful PFS benefit without bevacizumab, supporting MSBM as a complementary HRD assessment approach.
Katsutoshi Oda, Daisuke Shintani, Akira Nishijima, Mayuyo Mori, Kazuyoshi Kato, Shoji Nagao, Noriomi Matsumura, Masahiro Kagabu, Masataka Takenaka, Kosuke Yoshihara, Yosuke Konno, Junzo Hamanishi, Sho Sato, Shiro Takamatsu, Keiko Ueda, Kosuke Kashiwabara, Takashi Aoki, Kunihiro Nishimura, Kenji Tatsuno, Hiroyuki Aburatani, Kosei Hasegawa   +20 more
wiley   +1 more source

Mitochondrial metabolism and epigenetic crosstalk drive the SASP

Abstract Senescent cells drive tissue dysfunction through the senescence-associated secretory phenotype (SASP). We uncovered a central role for mitochondria in the epigenetic regulation of the SASP, where mitochondrial-derived metabolites, specifically citrate and acetyl-CoA, fuel histone acetylation at SASP gene loci, promoting their ...
Helene Martini, Jodie Birch, Francisco Marques, Stella Victorelli, Anthony Lagnado, Nicholas Pirius, Ana Franco, Gung Lee, Yeaeun Han, Jennifer Rowsey, Alexandre Gaspar-Maia, Aaron Havas, Rabi Murad, Xue Lei, Rebecca Porritt, Oliver Maddocks, Diana Jurk, Sundeep Khosla, Peter Adams, Joao Passos   +19 more
openaire   +2 more sources

Science and Applications Space Platform (SASP) End-to-End Data System Study

, 1981
The capability of present technology and the Tracking and Data Relay Satellite System (TDRSS) to accommodate Science and Applications Space Platforms (SASP) payload user's requirements, maximum service to the user through optimization of the SASP Onboard
Crawford, P. R., Kasulka, L. H.
core