Results 131 to 140 of about 26,150 (274)

Mitochondrial metabolism and epigenetic crosstalk drive the SASP

Abstract Senescent cells drive tissue dysfunction through the senescence-associated secretory phenotype (SASP). We uncovered a central role for mitochondria in the epigenetic regulation of the SASP, where mitochondrial-derived metabolites, specifically citrate and acetyl-CoA, fuel histone acetylation at SASP gene loci, promoting their ...
Helene Martini, Jodie Birch, Francisco Marques, Stella Victorelli, Anthony Lagnado, Nicholas Pirius, Ana Franco, Gung Lee, Yeaeun Han, Jennifer Rowsey, Alexandre Gaspar-Maia, Aaron Havas, Rabi Murad, Xue Lei, Rebecca Porritt, Oliver Maddocks, Diana Jurk, Sundeep Khosla, Peter Adams, Joao Passos   +19 more
openaire   +2 more sources

Cellular senescence and SASP in tumor progression and therapeutic opportunities

Molecular Cancer
Cellular senescence (CS), a permanent and irreversible arrest of the cell cycle and proliferation leading to the degeneration of cellular structure and function, has been implicated in various key physiological and pathological processes, particularly in cancer. Initially, CS was recognized as a barrier to tumorigenesis, serving as an intrinsic defense
Zening Dong, Yahan Luo, Zhangchen Yuan, Yu Tian, Tianqiang Jin, Feng Xu   +5 more
openaire   +3 more sources

CAFs‐mediated histone lactylation reprograms cholesterol metabolism in colorectal cancer to drive CD8+ T cell immunosuppression

The Journal of Pathology, EarlyView.
Abstract The progression of colorectal cancer (CRC) is critically regulated by cancer‐associated fibroblasts (CAFs) within the tumor microenvironment (TME), yet the specific molecular mechanisms by which CAFs influence CRC remain unclear. This study reveals the mechanism by which CAFs promote CRC malignant progression and immune suppression through ...
Huachi Li, Jun Hu, Lei Huang, Zihao Wang, Haoran Tao, Feng Cao, Min Xie   +6 more
wiley   +1 more source

Strong paracrine effects of the SASP from senescent SEO-COPD fibroblasts

Heliyon
Lung fibroblasts from Chronic Obstructive Pulmonary Disease (COPD) patients exhibit increased cellular senescence with higher levels of senescence-associated secretory phenotype (SASP) proteins, particularly in the severe early-onset COPD (SEO-COPD ...
R.A. Meuleman, W. Timens, W. Kooistra, M. van den Berge, C.-A. Brandsma, R.R. Woldhuis   +5 more
doaj   +1 more source

A pH‐Responsive fluorescence lifetime probe reveals GOT1 phase separation in cellular anti‐senescence

Smart Molecules, EarlyView.
Acidic pH triggers GOT1 phase separation via IDR1, recruiting ME1 to form ROS‐scavenging condensates that combat senescence, revealed by a FLIM‐based pH probe. Abstract Cellular senescence involves progressive acidification, but how cells sense and adapt to this pH shift remains unclear.
Ziyue Chen, Jiaqi Li, Yan Bao, Mengmeng Wang, Haoyan Chen, Mingjiong Zhang, Lina Ding, Shuangshuang Wu, Baoxing Shen   +8 more
wiley   +1 more source

Science and Applications Space Platform (SASP) End-to-End Data System Study [PDF]

, 1981
The capability of present technology and the Tracking and Data Relay Satellite System (TDRSS) to accommodate Science and Applications Space Platforms (SASP) payload user's requirements, maximum service to the user through optimization of the SASP Onboard
Crawford, P. R., Kasulka, L. H.
core  

Local Low‐Frequency Vibration Enhances Wound‐Healing and Modulates Cellular Senescence in Tissues and Exudates in a Hyperglycemic Rat Model

The Journal of Dermatology, EarlyView.
ABSTRACT Hard‐to‐heal wounds, such as diabetic foot ulcers and pressure injuries, pose major clinical challenges due to chronic inflammation and cellular senescence. Cellular senescence‐associated mechanisms, including stress‐responsive p53/p21 signaling and senescence‐associated secretory phenotype‐related inflammation, contribute to impaired wound ...
Daijiro Haba, Chihiro Takizawa, Qi Qin, Sanai Tomida, Ai Horinouchi, Hiromi Sanada, Gojiro Nakagami   +6 more
wiley   +1 more source

Understanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases

Allergy, EarlyView.
ABSTRACT Type 2 (T2) immunity is classically associated with defense against helminths and environmental threats, from a physiological perspective, and with allergies and eosinophilic inflammatory diseases, in a pathological sense. However, growing evidence reveals that T2 pathways also support other essential homeostatic functions, including tissue ...
Rodrigo Jiménez‐Saiz, Salvador Iborra, Carlos Blanco, Ruperto González‐Pérez, Emilio Nuñez‐Borque, Can Zeyneloglu, Huseyn Babayev, Ozlem Göksel, Tuncay Göksel, Musa Khaitov, Dmitry Kudlay, Yadong Gao, Mustafa Sevim, Marie‐Charlotte Brüggen, Oral Alpan, Ming Wang, Luo Zhang, María J. Torres, Mohamed Shamji, Mübeccel Akdis, Kari C. Nadeau, Ismail Ogulur, Cezmi A. Akdis   +22 more
wiley   +1 more source

Different Acupuncture Therapies Combined with Sulfasalazine for the Treatment of Ankylosing Spondylitis: Bayesian Network Meta-Analysis

Journal of Pain Research
Kaili Han,1,2 Mengquan Yu,3 Jing Chen,4 Shiheng Wang1 1School of Traditional Chinese Medicine, Binzhou Medical University, Yantai, People’s Republic of China; 2The Fifth Hospital of Qinhuangdao City, Qinhuangdao, People’s Republic of China; 3Muping ...
Han K, Yu M, Chen J, Wang S
doaj  

The first experimental demonstration of a SASP-based full Software Radio Receiver

, 2009
International audienceThis paper presents the principles of a Sampled Analog Signal Processor (SASP) dedicated to Software Radio mobile device. Many technological bottlenecks are to be overcome. The idea is to design a discrete analog signal processor to
Francois Rivet, Rivet, Francois, Deval, Yann, Belot, Didier, Yann Deval, Begueret, Jean-Baptiste, Dallet, Dominique, Cathelin, Philippe, Didier Belot, Dominique Dallet, Philippe Cathelin, Jean-Baptiste Begueret   +11 more
core   +1 more source