Results 151 to 160 of about 30,415 (217)

Pathophysiology and Molecular Signalling in Osteoporosis: Linking Risk Factors to Bone Loss

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Osteoporosis is a prevalent skeletal disorder characterised by progressive reduction in bone mass, microarchitectural deterioration, and increased fracture susceptibility. In India, approximately one‐third of the elderly population is affected by bone‐related disorders, and the global burden of osteoporosis continues to rise.
Pramoda G., Kamini Shivhare, Piyush Kumar Gupta, Amirhossein Sahebkar, Prashant Kesharwani, Rahul Shukla   +5 more
wiley   +1 more source

Targeting senescent cells in post-traumatic osteoarthritis: mechanisms, microenvironment remodeling, and translational prospects. [PDF]

PeerJ
E J, E Q, Zhou G.
europepmc   +1 more source

Multi‐Omics and Machine Learning‐Uncovered FLT1‐Mediated Epithelial‐Endothelial Crosstalk in Cellular Senescence Driving Clear Cell Renal Cell Carcinoma Malignancy

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
This study integrates multi‐omics data and machine learning to reveal FLT1 as a central mediator of epithelial‐endothelial crosstalk in clear cell renal cell carcinoma (ccRCC). We demonstrate that FLT1‐associated signaling promotes a senescence‐enriched tumor microenvironment, driving malignant progression. Spatial and single‐cell analyses confirm FLT1
Mouyuan Sun, Huchao Mao, Yaxian Luo, Mei Yang, Zhixu He, Shuangyang Li, Zhichao Liu, Lianjie Peng, Quanjie Zhang, Jingyu Zhang, Yan Zhang   +10 more
wiley   +1 more source

Single-Cell Profiling Reveals Distinct Immune Communication Networks in Centenarians and Elderly Controls. [PDF]

Aging Cell
Qiu L, Dong C, Zhao R, Ye H, Gao JL, Chen Y, Sun C, Gu Z.   +7 more
europepmc   +1 more source

p21 Knockdown as a Therapeutic Strategy for Focal Cartilage Injury Repair

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Intraarticular injection of lentiviral p21 shRNA (targeting Cdkn1a) into murine knees with full‐thickness cartilage defects reduces chondrocyte senescence while enhancing matrix repair with minimal hepatic off‐target effects. ABSTRACT Focal articular cartilage defects lack intrinsic regenerative capacity and can progress to osteoarthritis as no ...
Leila Larijani, Aria Ahadzadeh Ardebili, Nini Ortiz Vales, Andreas T. Stürmer, Roman J. Krawetz   +4 more
wiley   +1 more source

Impairment of Macrophage Functions by the Senescence-Associated Secretory Phenotype of Vascular Smooth Muscle Cells-Brief Report. [PDF]

Arterioscler Thromb Vasc Biol
Tsitsipatis D, Rodriguez Rivera T, Kaileh M, Okereke AN, Gupta A, Singh A, Raph SM, Henry-Smith C, Herman AB.   +8 more
europepmc   +1 more source

Cellular senescence and metabolic aging in type 2 diabetes: mechanistic insights and translational implications. [PDF]

Front Endocrinol (Lausanne)
Syed AR, Aloti RA, Awad BJ, Alghoul WII, Hassan MAMSA, Kharoufeh A, Rangraze I.   +6 more
europepmc   +1 more source

Significance of autoimune reactions to pancreatic juice in Crohn`s disease [PDF]

, 1988
Goebell, Harald, Otte, M., Scriba, Peter Christian, Stöcker, W.   +3 more
core   +1 more source

Exploiting cellular senescence in hematologic malignancies. [PDF]

Transl Oncol
Jiang P, Yang G, Li J, Tian X, Yang X, Yang S, Wei J, Zhang X, Liu J.   +8 more
europepmc   +1 more source

Cellular senescence in cancer immunology and potential therapeutic strategy. [PDF]

Front Oncol
Qian XD, Tao LD, Zhang LH, Ji AL, Wang L, Iqbal MM, Luo Y.   +6 more
europepmc   +1 more source