Aging‐Driven Immunosuppression: The Role of Tregs in the Ovarian Tumor Microenvironment
Aging Cell, Volume 25, Issue 5, May 2026.In the aged ovarian TME, cancer cells exhibit increased succinate production. Elevated extracellular succinate activates the SUCNR1 receptor on Tregs, promoting their recruitment and contributing to an immunosuppressive environment. This leads to diminished anti‐tumor T cell responses and reduced survival.
Mary P. Udumula +10 more
wiley +1 more source
Aging Cell, Volume 25, Issue 5, May 2026.Mechanistic study of AGEs‐induced OA progression via SIRT1/RANKL/RANK signaling‐mediated osteoclast–chondrocyte communication and cellular senescence. ABSTRACT Advanced glycation end products (AGEs) accumulate with aging and metabolic stress and are increasingly implicated in osteoarthritis (OA) pathology.
Yizhou Li +4 more
wiley +1 more source
Aging Cell, Volume 25, Issue 5, May 2026.Organ‐specific aging clocks integrating genomics, epigenomics, transcriptomics, proteomics, and metabolomics offer a more accurate assessment of biological aging than single‐omics approaches. This review proposes a multi‐omics framework emphasizing tissue data, longitudinal study designs, and clinically meaningful training outcomes to advance the ...
Maria Vasileiou +3 more
wiley +1 more source
A spatiotemporal atlas of senescence-associated secretory phenotype in fracture healing: stage-dependent mechanisms and therapeutic windows. [PDF]
Inflamm RegenChen B, Li G, Fang Q, Ding P, Gao Y.
europepmc +1 more source
Aging Cell, Volume 25, Issue 5, May 2026.Cellular senescence and mitochondrial dysfunction disrupt adipose tissue homeostasis during aging, but mechanisms remain unclear. HDAC9 expression increases with age in mouse adipose tissue and Hdac9 knockout mice showed reduced fat mass, senescence markers, and enhanced mitochondrial gene expression, respiration, and thiosulfate sulfurtransferase (Tst)
Brandee Goo +15 more
wiley +1 more source
Ensemble of Time-Evolving SASP Gene Sets Identifies IGFBP7 and CDKN1A as a Potential Marker Pair for Senescent Fibroblast Subpopulations Across Tissues. [PDF]
Int J Mol SciKim H +5 more
europepmc +1 more source
T Cell Immunosenescence in Inflammatory Skin Diseases: Pathogenesis and Therapeutic Targets
Aging Cell, Volume 25, Issue 5, May 2026.Immunosenescent T cells promote inflammatory skin diseases such as psoriasis, atopic dermatitis, rosacea, and seborrheic dermatitis via hyperactive signaling networks and SASP secretion. Consequently, intercepting downstream SASP, inhibiting internal pathways, or utilizing senolytics represents promising therapeutic interventions.
Conghui Liu +3 more
wiley +1 more source
Senescent Factors Suppress Innate Antiviral Immunity in Aged Mice via Two Distinct Mechanisms. [PDF]
Aging CellZhang X, Zhang Q, Wang L, Li S, Shu HB.
europepmc +1 more source
T Cell Receptor Repertoires Across the Continuum of Vascular, Myocardial, and Age‐Related Diseases
Immunological Reviews, Volume 339, Issue 1, May 2026.ABSTRACT Cardiovascular diseases (CVD) are shaped by a complex interplay with immune mechanisms. In particular, the distinct roles of antigen‐specific T cell mechanisms are emerging as critical determinants across a broad spectrum of conditions, ranging from atherosclerosis, myocardial infarction (MI), heart failure (HF), and myocarditis. Because these
Leon Richter +3 more
wiley +1 more source
Therapy-Induced Senescence Shapes Extracellular Matrix Niches and Fibroblast Function in Head and Neck Squamous Cell Carcinoma. [PDF]
Cancers (Basel)Montero-Vergara J +3 more
europepmc +1 more source