Results 141 to 150 of about 26,150 (274)
Brain Pathology, EarlyView.Brain metastasis‐associated fibroblasts are active stromal components of the metastatic niche characterised by extracellular matrix remodelling and production of pro‐migratory mediators. They promote monocyte and cancer cell migration and enhance cancer cell invasion while having no growth‐promoting effect on cancer cells.
Barbora Výmolová +19 more
wiley +1 more source
Targeting hexokinase 2 to induce breast cancer cell senescence
British Journal of Pharmacology, EarlyView.Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof +8 more
wiley +1 more source
Macrophage Lipid Homeostasis Drives IVDD via a Senescence‐Dependent Impairment of Efferocytosis
Cell Proliferation, EarlyView.Intervertebral disc degeneration (IVDD) has been a leading cause of low back pain and lacks disease‐modifying therapies. Although dysregulated disc lipid metabolism is implicated, its impact on the immune microenvironment, particularly macrophages, remains unknown.
Jinyu Wang +12 more
wiley +1 more source
ANT1 and the SASP: Beyond the Bioenergetic Void
American Journal of Respiratory Cell and Molecular Biology, 2023 openaire +2 more sources
, 2000 The α/β-type small, acid-soluble spore proteins (SASP) are a family of highly conserved, non-specific DNA binding proteins which are found at very high levels within the spores of Bacillus and Clostridium species.
Hayes, Christopher Stephen
core +1 more source
Meccanismi molecolari della SASP (fenotipo secretorio associato alla senescenza)
, 2014 L’invecchiamento è la principale causa di decesso in tutto il mondo. Tra i vari meccanismi biologici e molecolari che contribuiscono all’invecchiamento ed alle patologie ad esso associate c’è sicuramente l’infiammazione cronica a basso grado, denominata ...
Prattichizzo, Francesco
core
Type 1 diabetes (T1D) is a metabolic disease resulting from progressive autoimmune destruction of insulin-producing pancreatic beta cells. Although the majority of beta cells are lost in T1D, a small subset undergoes senescence, a stress response ...
Brawerman, Gabriel +7 more
core +1 more source
Cell Proliferation, EarlyView.Mechanical strain disrupts the lysosome‐mitochondria axis via GLS1‐mediated ammonia toxicity, causing NP cell death and ECM breakdown in IVDD. CB839‐mediated GLS1 inhibition effectively rescues cellular homeostasis and alleviates disc degeneration.
Yang Zhang +11 more
wiley +1 more source
Cell Proliferation, EarlyView.HK2 is upregulated in osteoarthritis and accelerates disease progression via a glycolysis‐independent non‐metabolic mechanism. It recruits PRKN to degrade MYH10, reducing COL1A1 mRNA stability and inducing senescence. Purpurin disrupts this pathogenic pathway with therapeutic potential.
Zhencan Lin +9 more
wiley +1 more source