Results 141 to 150 of about 22,235 (292)

Senescent Human Liver Endothelial Cells Mediate CD4+ T Cell Recruitment via ICOSL

Immunology, EarlyView.
In this study, we detect senescent endothelial cells within chronically diseased human liver tissues. Next, we develop a novel protocol for the induction of paracrine senescence in primary human liver endothelial cells and explore their functionality.
Daniel A. Patten, Amy Lumley, Alex L. Wilkinson, Ayla O’Keeffe, Kelvin Yin, Niranjan Shirgaonkar, Ran Gao, Ramanuj DasGupta, Matthew Hoare, Shishir Shetty   +9 more
wiley   +1 more source

Basal Cells Contribute to Pulmonary Fibrosis via SP1-Mediated Senescence-Associated Secretory Phenotype. [PDF]

Clin Respir J
Basal cells are expanded within the small airway epithelium in IPF. This change is associated with the severity of fibrosis and may participate in disease pathogenesis via SP1‐mediated senescence‐associated secretory phenotype (SASP). ABSTRACT Idiopathic pulmonary fibrosis is a progressive interstitial lung disease with limited treatment options and ...
Wang X, Li Y, Zhao L, Zhang X, Liu M, Dai H.   +5 more
europepmc   +2 more sources

SASP guidance

This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Mode of access: Internet from the Oregon Government ...

core  

Exploring Transcriptional Regulation of Beta Cell SASP by Brd4-Associated Proteins and Cell Cycle Control Protein p21

Type 1 diabetes (T1D) is a metabolic disease resulting from progressive autoimmune destruction of insulin-producing pancreatic beta cells. Although the majority of beta cells are lost in T1D, a small subset undergoes senescence, a stress response ...
Brawerman, Gabriel, Thompson, Peter J., Gabriel Brawerman, Manji, Jasmine, Jasmine Manji, Pipella, Jasmine, Jasmine Pipella, Peter J. Thompson   +7 more
core   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source

Proceedings of the EAA Spatial Audio Signal Processing symposium: SASP 2019

, 2019
International ...
Noisternig, Markus, Rafaely, Boaz, Katz, Brian F. G., Katz, Brian, F. G.   +3 more
core   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Different Acupuncture Therapies Combined with Sulfasalazine for the Treatment of Ankylosing Spondylitis: Bayesian Network Meta-Analysis

Journal of Pain Research
Kaili Han,1,2 Mengquan Yu,3 Jing Chen,4 Shiheng Wang1 1School of Traditional Chinese Medicine, Binzhou Medical University, Yantai, People’s Republic of China; 2The Fifth Hospital of Qinhuangdao City, Qinhuangdao, People’s Republic of China; 3Muping ...
Han K, Yu M, Chen J, Wang S
doaj  

Measuring the Senescence-Associated Secretory Phenotype

Biomedicines
Cellular senescence is a fundamental hallmark of aging, contributing to tissue dysfunction and chronic disease through the senescence-associated secretory phenotype (SASP).
Achilleas Karras, Georgios Lioulios, Konstantia Kantartzi, Asimina Fylaktou, Stylianos Panagoutsos, Maria Stangou   +5 more
doaj   +1 more source

A role for fibroblast-derived SASP factors in the activation of pyroptotic cell death in mammary epithelial cells.

In normal tissue homeostasis, bidirectional communication between different cell types can shape numerous biological outcomes. Many studies have documented instances of reciprocal communication between fibroblasts and cancer cells that functionally ...
Ireland M. Murphy (17775468), Lisa M. Hom (15180039), Pinyan Liu (17413434), Zachary T. Schafer (14910791), Shannon Culbert (15180048), Jamie Campbell (15127165), Seunghoon Sun (15180042)   +6 more
core   +1 more source