Phloridzin Mitigates Aging‐Associated Periodontitis by Restraining Inflammatory Cell Death
Journal of Periodontal Research, EarlyView.Phloridzin attenuated oxidative stressinduced senescence, inflammatory responses, and osteogenic dysfunction in HPDLCs. In an aging‐associated experimental periodontitis model, phloridzin alleviated alveolar bone loss, suggesting its potential to maintain periodontal tissue integrity under aging‐related inflammatory conditions.
Da Eun Lee +2 more
wiley +1 more source
G-SASP-PREPRINT-Psychosis-PhytoIntelligence
Objective: To propose a non-synthetic, μlti-ligand therapeutic protocol for the modulation of acute and chronic psychosis, utilizing the PhytoIntelligence 3.1 (PI-3.1) discovery pipeline. Hypothesis: The "Mono-Target Fallacy" of synthetic antipsychotics (primarily D2 antagonism) accelerates receptor upregulation (REVOLVER resistance).
openaire +3 more sources
A Deep-Learning Based Biomarker of Systemic Cellular Senescence Burden to Predict Mortality and Health Outcomes. [PDF]
Aging CellZhao S +9 more
europepmc +1 more source
Bone biology in aging periodontal and peri‐implant tissues
Periodontology 2000, EarlyView.Abstract Background Periodontal disease is an age‐related chronic inflammatory condition leading to tooth loss. Dental implants are an option for replacement of lost teeth in older adults. However, age‐related changes to alveolar bone may have pathological implications for its role in supporting the dentition and dental implants.
Dalia Rasheed Issa +2 more
wiley +1 more source
Cardiotrophin 1: A Novel SASP Marker in Senescent MCF7 Cells
Cellular senescence is a permanent arrest of the cell cycle in response to many stress factors and is characterized by excessive secretory ...
Şimay Demir, Yaprak Dilber +3 more
core +1 more source
Extracellular ATP Signaling as a Proposed Mechanistic Link to Cellular Senescence in Cardiovascular Diseases. [PDF]
J Inflamm ResLiu X +10 more
europepmc +1 more source
Metabolically Active but Dysfunctional: The Impact of Senescent Cells and SASP
The accumulation of senescent cells in metabolic tissues, including adipose tissue, liver, pancreas, and skeletal muscle – along with the senescence-associated secretory phenotype (SASP) has emerged as a significant factor in developing chronic ...
Zarqa Alam +5 more
core +1 more source
Periodontology 2000, EarlyView.Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng +4 more
wiley +1 more source
Paracrine bone-derived senescent secretome is associated with spatially patterned extracellular matrix remodeling and altered biomechanics in human brain organoids. [PDF]
Stem CellsKim C +8 more
europepmc +1 more source
Understanding exosomes in facial esthetics and skin aging
Periodontology 2000, EarlyView.Abstract Background Skin aging is a multifactorial process mediated by intrinsic (genetic and metabolic) and extrinsic (environmental) factors leading to functional and structural deterioration, including wrinkles, loss of collagen and elastin, as well as various pigmentation disorders.
Richard J. Miron +3 more
wiley +1 more source