Results 181 to 190 of about 26,150 (274)

Born early, age fast: Consequences of premature birth on chronic disease and accelerated ageing

The Journal of Physiology, EarlyView.
Abstract figure legend ELGANs are exposed to several postnatal pro‐oxidant stressors, including ambient and supplemental oxygen, mechanical ventilation, infections, hyperalimentation, excessive glucocorticoids and intermittent hypoxia. Since endogenous antioxidant defences are underdeveloped, this imbalance promotes oxidative stress and inflammation ...
Estelle B. Gauda, Julijana Ivanovska, Dwayne Mascarenhas, Jeffrey Antwi, Atefeh Mohammadi, Bonny Jasani   +5 more
wiley   +1 more source

Nrf2 Activation Induces Fibroblast Senescence and Promotes Melanosome Accumulation in a Fibroblast-Keratinocyte Co-Culture Model. [PDF]

Biomol Ther (Seoul)
Yoon JH, Kil IS, Cho S, Park S, Kim HS, Kim JH, Cho JY.   +6 more
europepmc   +1 more source

Cancer‐associated fibroblast heterogeneity across solid and haematological malignancies: Lessons from colorectal cancer and multiple myeloma

The Journal of Physiology, EarlyView.
Abstract figure legend CAF origins and plasticity give rise to distinct phenotypes with immunosuppressive functions in colorectal cancer and multiple myeloma. These distinct CAF phenotypes contribute to immunosuppressive tumour microenvironments through ECM remodelling, cytokine signalling and immune regulation.
Hui Mo, Haoyan Han, Michael O'Dwyer, Eileen Reidy, Aideen E. Ryan   +4 more
wiley   +1 more source

Senescence utilises inflammatory caspases to drive SASP

Aging, 2019
Wiggins, Kimberley A., Clarke, Murray CH.   +1 more
openaire   +2 more sources

Radiation‐Induced Skin Injury in Cancer Radiotherapy: From Mechanisms to Management

Advanced Oncology, Volume 1, Issue 1, December 2026.
Radiation‐induced skin injuries (RISI) remain a significant challenge faced by cancer patients receiving radiotherapy (RT). This perspective article examines the pathophysiology of RISI and evaluates the currently existing and emerging therapeutic strategies, including stem cell‐derived exosomes and advanced hydrogels.
Zeynep Meral Toutoungi, Nukhet Aykin‐Burns, Jingyi Chen, Younghye Song   +3 more
wiley   +1 more source

A Case of Recurrent Gastric Cancer in Which Rheumatoid Arthritis and Sjögren's Syndrome Became Evident With Nivolumab

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT A 59‐year‐old man with recurrent gastric cancer began nivolumab as third‐line therapy and subsequently experienced joint pain and dry eyes. Symptoms worsened despite NSAIDs. He was diagnosed with rheumatoid arthritis and Sjögren's syndrome, associated with nivolumab, and was successfully treated with immunosuppressive and anti‐rheumatic ...
Haruhiko Takemoto, Keiji Nishibeppu, Takeshi Kubota, Hiroyuki Inoue, Kazuya Takabatake, Hirotaka Konishi, Hitoshi Fujiwara, Atsushi Shiozaki   +7 more
wiley   +1 more source

Cellular senescence in multiple sclerosis: hallmarks, immunosenescence, and therapeutic implications. [PDF]

Front Immunol
Yousef A, Seubert JM, Power C, Nathoo N.
europepmc   +1 more source

Ferroportin deficiency drives olaparib resistance in ovarian cancer via the cGAS–STING–STAT3 survival axis

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
Abstract Background Ovarian cancer (OC) remains the most lethal gynaecological malignancy, and acquired resistance to PARP inhibitors such as olaparib represents a major clinical challenge. Although dysregulation of iron metabolism has been implicated in tumorigenesis, the specific role of the iron exporter SLC40A1 (ferroportin, FPN) in mediating ...
Jiagui Song, Zhengyang Guo, Decao Yang, Ping Yu, Yinjia Li, Zhuhui Yuan, Xiaojuan Ma, Xianlong Li, Hongyan Guo, Lixiang Xue, Tong Liu   +10 more
wiley   +1 more source

Pharmacokinetics of Salazosulfapyridine (Sulfasalazine, SASP). IV. Pharmacokinetics of SASP in the rat following consecutive oral doses.

Drug Metabolism and Pharmacokinetics, 1991
SJÖQUIST, Birgitta, AHNFELT, Nils-Otto, ANDERSSON, Stig, d'ARGY, Roland, HATSUOKA, Masanori, SUGA, Tetsuya, WATANABE, Takafumi, LJUNGSTEDT-PÅHLMAN, Ingrid   +7 more
openaire   +2 more sources

Stemonine Alleviates UVB‐Induced Keratinocyte Senescence by Activating SIRT3

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
Stemonine, a natural alkaloid, protects human HaCaT keratinocytes against UVB‐induced skin senescence. Stemonine attenuated oxidative stress, mitochondrial dysfunction, DNA damage, and key senescence markers. It functioned by upregulating the expression and activity of SIRT3.
Kun Chen, Xudong Yan, Guixiang You, Mingyang Li, Chen Chen, Xiaolan Yu, Jiyi Xia   +6 more
wiley   +1 more source