Results 181 to 190 of about 22,235 (292)

Mechanisms and Clinical Manifestations of Age‐Related Impairment in Wound Healing

International Wound Journal, Volume 23, Issue 7, July 2026.
ABSTRACT Chronic wounds account for a considerable burden on the overall US healthcare system, affecting an estimated 10.2 million people and costing as much as $148 billion dollars in 2022 alone. Elderly patients suffer disproportionately, as nearly 85% of the chronic wound population is over the age of 65 years old.
Daniel A. Rabin, Tiffany Kim, Julia K. Kaniuk, Marlynn P. Lopez, Spencer Green, Aneeq S. Chaudhry, Katherine Kozlowski, Diana Griffin, Tarifa H. Adam, Thomas A. Mustoe, Robert D. Galiano   +10 more
wiley   +1 more source

Transcriptomic Insights into the Association of IL-1 Signaling with the Senescence-Associated Secretory Phenotype in Human Fibroblasts. [PDF]

Genes (Basel)
Yilmaz V.
europepmc   +1 more source

Mechanism and Intervention of the NPY1R/CREB Signaling Axis in Regulating Inflammatory Response in Aged Ovarian Granulosa Cells and Ovarian Senescence

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Aging‐associated upregulation of NPY1R drives p‐CREB activation, triggering inflammation, mitochondrial dysfunction, and extracellular matrix imbalance to promote ovarian senescence. Pharmacological inhibition of NPY1R with BIBO 3304 restores ovarian homeostasis, highlighting a therapeutic strategy for reproductive aging. ABSTRACT Ovarian senescence is
Junnan Fang, Chaoying Wang, Shuaishuai Guo, Yiping Zhang, Yang Zhang, Huihui Wang, Yue Kong, Haixia Jin, Lin Qi, Yan Liu, Zhaoting Wu, Fuli Zhang, Shuang Wen, Xiaopeng Wang, Guang Yang, Guidong Yao   +15 more
wiley   +1 more source

Senescence utilises inflammatory caspases to drive SASP

Aging, 2019
Wiggins, Kimberley A, Clarke, Murray Ch
openaire   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, Volume 20, Issue 6, Page 1429-1452, June 2026.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Synergistic senolytic-regenerative therapy significantly extends healthspan and lifespan. [PDF]

J Transl Med
Ichim TE, Markov N, Lopes G, Pascual KA, Evans A, Reznik R, Bykoriz V, Fortunati CA, Minev B, Ramos RA, Bajnath A, Lin E, Hu J, Marincola FM, Rath A, Barrett B, Jurow A, Sankhala KK, Furman D, Reznik BN.   +19 more
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, Volume 7, Issue 2, Page 52-66, June 2026.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Senolytic Treatment With Fisetin Reverses Age-Related Endothelial Dysfunction Partially Mediated by SASP Factor CXCL12. [PDF]

Aging Cell
Mahoney SA, Mazan-Mamczarz K, Tsitsipatis D, VanDongen NS, Henry-Smith C, Okereke AN, Munk R, Darvish S, Murray KO, De S, Gorospe M, Seals DR, Rossman MJ, Herman AB, Clayton ZS.   +14 more
europepmc   +1 more source

Pharmacokinetics of Salazosulfapyridine (Sulfasalazine, SASP). IV. Pharmacokinetics of SASP in the rat following consecutive oral doses.

Drug Metabolism and Pharmacokinetics, 1991
SJÖQUIST, Birgitta, AHNFELT, Nils-Otto, ANDERSSON, Stig, d'ARGY, Roland, HATSUOKA, Masanori, SUGA, Tetsuya, WATANABE, Takafumi, LJUNGSTEDT-PÅHLMAN, Ingrid   +7 more
openaire   +2 more sources

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source