Results 201 to 210 of about 26,150 (274)

Integrative identification and preliminary validation of senescence-associated secretory phenotype-related candidate biomarkers in type 2 diabetes. [PDF]

PeerJ
Liu B, Jia J, Wang N, Yin C, Xu L, Lang H.   +5 more
europepmc   +1 more source

Histone Modifications at the Intersection of Aging, Neuroinflammation and Metabolism in Alzheimer's Disease

Aging Cell, Volume 25, Issue 11, November 2026.
This review examines how histone modifications integrate aging, metabolic dysfunction and neuroinflammation to shape persistent, cell‐type‐specific chromatin states in Alzheimer's disease. By distinguishing causal regulation from association through perturbation, persistence and reversibility, it highlights metabolic–epigenetic feedback loops and ...
Junyi Liang, Huawen Cao, Xiumin Ren, Nan Sha, Xueqing Han, Ling Jiang, Bin Liu, Weiming Zhao   +7 more
wiley   +1 more source

A Novel Peptide Targeting the USP25–SIRT1 Interaction Activates SIRT1 to Suppress Cell Senescence

Aging Cell, Volume 25, Issue 11, November 2026.
USP25‐mediated K63‐linked deubiquitination of SIRT1 at K506 and K513 suppresses its activity to promote senescence. These findings unveil a novel aging regulatory axis and identify a peptide targeting the USP25–SIRT1 interaction for anti‐senescence therapeutic intervention.
YuJuan Zhou, Xinshu Wang, Jiyuan Zhang, Hanqiong Qiang, Xinru Zhao, Jingyi Luo, Yanjun Ji, Jiakai Yao, Linhui Zhai, Tingting Zhang, Ke Li, Yuping Chen, Jian Yuan, Lei Li, Yunhui Li   +14 more
wiley   +1 more source

TOP2A Maintains Heterochromatin Stability by Sustaining LMNB1 Expression to Counteract Senescence

Aging Cell, Volume 25, Issue 11, November 2026.
Depletion of TOP2A accelerates MSC senescence and disrupts heterochromatin integrity. TOP2A directly regulates LMNB1 expression to maintain MSC nuclear integrity and epigenomic stability. Overexpression of TOP2A counteracts MSC senescence through Lamin B1‐mediated chromatin reorganization and epigenomic stabilization.
Ke Cheng, Yaru Wang, Yueyuan Pan, Wenjun Zhang, Denghong Yu, Qi Zhou, Zhiqian Zhong, Ruyi Mei, Chaoliang Xu, Ayidana Hayierhan, Yumei Ma, Yien Xu, Qingdong Xie, Pingnan Sun, Junzhi Zhou, Xiaoling Zhou   +15 more
wiley   +1 more source

Role of Sirtuins in the Hallmarks of Skin Aging

Aging Cell, Volume 25, Issue 11, November 2026.
In the skin, sirtuins support the integrity of the epidermis and dermis and protect the skin from environmental insults by maintaining cellular homeostasis. Sirtuins decline with chronological age, contributing to the biological hallmarks of aging, with increasing evidence emerging of their specific roles in skin aging.
Rishabh Kala, Antonella Rella, Whitby Eagle, Earl Goyarts, Jian Cao, Binwei Deng, Kelly Dong, Chloe Schmit, Matthew Cappock, Krystle Corallo, Jacqueline Trivero   +10 more
wiley   +1 more source

Inflammaging reshapes the immune ecosystem in IgG4-related dacryoadenitis and sialadenitis. [PDF]

Rheumatology (Oxford)
Yamamoto M, Kamekura R, Uehara M, Ichii Y, Takano K.   +4 more
europepmc   +1 more source

MKP‐2 Genetic Depletion Modulates Adipose Lipid Composition, Cellular Senescence, and Aging in Mice

Aging Cell, Volume 25, Issue 11, November 2026.
Excess white adipose tissue (WAT) accumulation promotes aging by increasing the risk of insulin resistance and chronic diseases and reduced lifespan. MKP‐2 deficiency protects against premature senescence in cells and WAT and is associated with adipose lipid remodeling, improved metabolic health, and longer lifespan.
Morgan Welch, Nabin Ghimire, Shauri Smith, Cassandra Secunda, Alexis Fink, Alissar Sleiman, Laura Chambliss, Christopher Pinckard, Chloe Reyes, Priya Katta, Anna Ai, Benjamin R. Harrison, Ahmed Lawan   +12 more
wiley   +1 more source

The Relationship Between Immunogenic Cell Death and Cellular Senescence in Cancer Immunotherapy. [PDF]

Life (Basel)
Shin SA, Kim M, Kim M, Choi S, Park HH, Lee CS.   +5 more
europepmc   +1 more source

Long‐Term Post‐Mitotic Culture of Human Fibroblasts Recapitulates and Accelerates Features of In Vivo Aging and Enables Dynamic Testing of Anti‐Aging Compounds

Aging Cell, Volume 25, Issue 11, November 2026.
Human fibroblasts undergo accelerated molecular aging in long‐term culture, recapitulating in‐vivo aging signatures and increasing age‐related heterogeneity. Direct neuronal conversion preserves biological age, enabling pseudo‐longitudinal studies and a scalable platform to evaluate anti‐aging interventions, including the differential effects of ...
Larissa Traxler, Lukas Karbacher, Oliver Borgogno, Taylor Ozbun, Kylie Champion, Anna Smaling, Lucia Zhou‐Yang, Joseph R. Herdy, Lena Böhnke, Barbara C. Böckle, Fred H. Gage, Hildegard I. D. Mack, Michaela Defrancesco, Jerome Mertens   +13 more
wiley   +1 more source

Cellular senescence and regulated cell death in cancer: mechanisms, cross-regulatory networks and therapeutic implications. [PDF]

J Hematol Oncol
Du L, Zhang Y, Liang R, Song B, Zhou J, Xia X, Liu C, Wu K, Cao X.   +8 more
europepmc   +1 more source