Results 221 to 230 of about 26,150 (274)

Rhenium‐Based β‐Galactosidase Probe Allows Senescence Profiling by Mass Cytometry

Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.
Senescence‐associated β‐galactosidase (SA‐β‐Gal) activity is a widely accepted biomarker of cellular senescence, yet its integration with other senescence markers has been limited by available detection methods. Here, we introduce ReGal, a mass cytometry‐compatible SA‐β‐Gal activity probe that can be multiplexed with established markers of senescence ...
Adam Tam, Kris Elbein, Aleida G. Gonzalez, Edgar A. Arriaga, Mark Nitz   +4 more
wiley   +2 more sources

Mitochondrial Dysfunction as a Context‐Dependent Driver and Amplifier of the SASP: Targeting the mtDNA–cGAS–STING Axis for Next‐Generation Senotherapeutics

Journal of Cellular and Molecular Medicine, Volume 30, Issue 21, November 2026.
ABSTRACT Cellular senescence combines stable cell‐cycle arrest with mitochondrial and innate immune remodelling that shapes the senescence‐associated secretory phenotype (SASP). This narrative review evaluates mitochondrial dysfunction as a context‐dependent initiator or amplifier of senescence and examines mitochondrial DNA (mtDNA) sensing through ...
Hamza Kamaran Hama, Mohammed Ali Hama, Musa M. Zorab, Amirreza Gholami, Ammar Mohammed Al‐Farga   +4 more
wiley   +1 more source

4‐Octyl Itaconate Attenuates Age‐Induced Parotid Gland Dysfunction Through the Suppression of Fibrosis and Lipid Deposition by AMPKα/PPARα and the Inhibition of Oxidative Stress via the AMPKα/Nrf2 Signaling Pathway

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
4‐Octyl itaconate (4‐OI) attenuates age‐induced parotid gland dysfunction through the suppression of fibrosis and lipid deposition by AMPKα/PPARα and the inhibition of oxidative stress via the AMPKα/Nrf2 signaling pathway. 4‐OI activates AMPKα, which in turn stimulates both the PPARα and Nrf2 pathways. Activation of PPARα enhances FAO and reduces lipid
Yun Chen, Tianyuan Gong, Zhongyan Shan, Jing Lai, Yiming Xu, Han Zhao, Lilei Zhu   +6 more
wiley   +1 more source

Future directions of osteoanabolic therapies in osteoporosis: Integrating current anabolic agents and emerging senescence-targeted strategies. [PDF]

Best Pract Res Clin Rheumatol
Brooks HW, Cusick NC, Wu S, Farr JN.
europepmc   +1 more source

The Senescence-Malignancy Axis: An Inflammaging Perspective. [PDF]

Antioxidants (Basel)
Patrono I, Sonnessa M, Trerotola M, Giudetti AM, De Summa S, Zito FA, Saponaro C, Vergara D.   +7 more
europepmc   +1 more source

Senolytic Interventions Enhance the Anti-metastatic Activity of Chemotherapy in Prostate Cancer. [PDF]

Cancer Res
Zhou L, Murphy KC, Giwa HK, Hu K, Ma B, Brassil ML, Chang EH, DeMarco KD, Pradhan AJ, Sroka EM, Parikh CN, Mori H, Zhu LJ, Kelliher MA, Ruscetti M.   +14 more
europepmc   +1 more source

Abstract Supplement HIV Glasgow 8–11 November 2026, Glasgow, UK/Virtual

Journal of the International AIDS Society, Volume 29, Issue S6, November 2026.
wiley   +1 more source