Results 231 to 240 of about 22,235 (292)

The Role of Cellular Senescence in Obstructive Airway Diseases: From Mechanisms to Therapeutic Targets. [PDF]

Int J Mol Sci
Vrouvaki A, Moustaka Christodoulou M, Hillas G, Loukides S, Fouka E.   +4 more
europepmc   +1 more source

Ligand‐Independent Activation of Notch1 by Cathepsin L Induces CUX1/p16INK4a‐Dependent Endothelial Senescence Associated With Atherosclerosis

Aging Cell, Volume 25, Issue 6, June 2026.
CTSL activates Notch1/RBPJ in a ligand‐independent fashion, inducing CUX1/p16INK4a‐dependent endothelial senescence associated with atherosclerosis. ABSTRACT Our post‐GWAS functional analysis revealed that cathepsin L (CTSL) is an upstream regulator of CUX1, and it induces p16INK4a‐dependent and atherosclerosis‐associated senescence by indirectly ...
Yuwei Wu, Lili Lu, Shaoyang Yan, Zewen Du, Danli Jiang, Ting Wu, Qichao Wu, Jie Liu, Johny Ebin, Wei Sun, Partha Dutta, Jay Xiaojun Tan, Jonathan K. Alder, Gang Li   +13 more
wiley   +1 more source

Ferroptosis-Driven Senescence Loop as a Central Amplifier of Osteoarthritis Progression. [PDF]

Biomol Ther (Seoul)
Hossain R, Lee HJ, Hossain MS, Jeong J, Lee CJ, Hwang SC.   +5 more
europepmc   +1 more source

Chimeric Antigen Receptor T Cells as Living Therapeutics Targeting Senescence and Age-Related Diseases. [PDF]

Research (Wash D C)
Shao Q, Chen D, Shao W, Ye Q.
europepmc   +1 more source

Research progress on cellular senescence in the pathogenesis and treatment of osteoarthritis and temporomandibular joint osteoarthritis. [PDF]

J Oral Facial Pain Headache
Wang Y, Jing X, Li Y.
europepmc   +1 more source

iLDA‐SGCN: Identifying Associations Between Age‐Related Diseases and Long Non‐Coding RNAs Using Dual Graph Convolutional Networks

Aging Cell, Volume 25, Issue 6, June 2026.
iLDA‐SGCN integrates singular value decomposition and dual graph convolutional networks to predict lncRNA‐disease associations. It achieves superior performance on two benchmark datasets and identifies 33 candidate lncRNAs across 8 age‐related diseases.
Yu Guo, Shizheng Qiu, Zhishuai Zhang, Jirui Guo, Haozheng Liang, Huanyu You, Fengjuan Lu, Yanwei Xu, Yang Hu   +8 more
wiley   +1 more source

T Cell Immunosenescence in Inflammatory Skin Diseases: Pathogenesis and Therapeutic Targets. [PDF]

Aging Cell
Liu C, Yang M, Xiao F, Zeng J.
europepmc   +1 more source

Senescent BMSC‐Derived Thbs1 Drives Inflammaging and Impairs Bone Regeneration by Suppressing PINK1/Parkin‐Mediated Mitophagy in Macrophages

Aging Cell, Volume 25, Issue 6, June 2026.
Aging BMSC‐derived Thbs1 activates the macrophage TGF‐β/Smad3 pathway to transcriptionally repress Pink1, impairing mitophagy and causing mitochondrial ROS accumulation. This redox imbalance drives M1 polarization and IL‐6 secretion. IL‐6 feeds back to BMSCs via the JAK/STAT3 pathway to inhibit osteogenesis and upregulate Thbs1, establishing a self ...
Yifeng Xing, Jingjing Su, Yanjun Lin, Nengwen Huang, Sihui Zhang, Yuwei Zhou, Jie Lu, Weiping Chen, Kaixun He, Wenxiu Yuan, Yang Li, Geyuan Zheng, Pengyuan Hu, Dong Wu, Yanjing Ou, Jiang Chen   +15 more
wiley   +1 more source

Cellular Senescence in Neurodegeneration: From Cell Types to Therapeutic Opportunities. [PDF]

Biomedicines
Zawadzka M, Rydzek J, Lizon J, Krupa Z, Wrona J, Woźniak S.   +5 more
europepmc   +1 more source