Results 251 to 260 of about 26,150 (274)
International Journal of Molecular Sciences, 2022 Chemotherapy remains the most common cancer treatment. Although chemotherapeutic drugs induce tumor cell senescence, they are often associated with post-therapy tumor recurrence by inducing the senescence-associated secretory phenotype (SASP). Therefore,
Baiqu Huang, Yu Zhang, Jun Lu
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The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related Diseases [PDF]
Biology, 2020 Cellular senescence represents a robust tumor-protecting mechanism that halts the proliferation of stressed or premalignant cells. However, this state of stable proliferative arrest is accompanied by the Senescence-Associated Secretory Phenotype (SASP),
Alessandra Soriani +2 more
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SASP Reflects Senescence [PDF]
EMBO Reports, 2009 Senescence is a permanent state of cell cycle arrest that—unlike quiescence—is unresponsive to growth factors. Originally described in terms of the replicative exhaustion of cultured fibroblasts (Hayflick & Moorhead, 1961), it has since been shown that senescence can occur prematurely upon oncogene induction and other cellular stresses.
Masashi Narita
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SASP: Tumor Suppressor or Promoter? Yes! [PDF]
Trends in Cancer, 2016 Cellular senescence is a permanent growth arrest in cells with damage or stress that could lead to transformation. Some tumor cells also undergo senescence in response to chemotherapy. Senescent cells secrete cytokines and other factors of the senescence-associated secretory phenotype (SASP) that contribute to tumor suppression by enforcing arrest and ...
James G Jackson
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Astrocyte Senescence and SASP in Neurodegeneration: Tau Joins the Loop
Cell Cycle, 2021Tau accumulation is a core component of Alzheimer's disease and other neurodegenerative tauopathies. While tau's impact on neurons is a major area of research, the effect of extracellular tau on astrocytes is largely unknown. This article summarizes our recent studies showing that astrocyte senescence plays a critical role in neurodegenerative diseases
Curtis C. Harris, Jessica Beck, Izumi H
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CancersCellular senescence is defined as a state of permanent cell cycle arrest, providing a natural barrier against cancer. However, senescent cells are very metabolically active and secrete a complex mixture of bioactive molecules collectively known as the ...
Joanna Katarzyna Strzelczyk +2 more
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Signatures analysis systems prototype (SASP)
2009 IEEE Conference on Technologies for Homeland Security, 2009Sim-G Technologies, LLC (Sim-G), has developed a prototype collaborative system to aid in countering the threat of improvised explosive devices (IED). This is accomplished through the use of knowledge discovery, collaboration, data mining, signature visualization and GIS tools.
Dennis G. Perry +2 more
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SASP gene delivery: A novel antibacterial approach
Drug News & Perspectives, 2009Antibiotic resistance is a global problem, and with bacteria having developed resistance to all approved antibacterial agents there is a growing need for innovative solutions. Phico Therapeutics has developed a new class of antibacterial agent, a platform technology called SASPject.
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Unmasking senescence: context-dependent effects of SASP in cancer
Nature Reviews Cancer, 2019Cellular senescence plays a critical role in tumorigenesis. Once thought of as a tissue culture artefact by some researchers, senescence is now a major field of study. Although there are common molecular mechanisms that enforce the growth arrest that characterizes the phenotype, the impact of senescence is varied and can, in some instances, have ...
Douglas V. Faget +2 more
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Effects of NAT2 polymorphism on SASP pharmacokinetics in Chinese population
Clinica Chimica Acta, 2009Sulfasalazine (SASP) pharmacologic actions are widely applied in clinical therapy. The role of N-Acetyltransferase 2 (NAT2) in the pharmacokinetics of SASP and its metabolites has not been clarified. We investigated the effects of genetic polymorphism of NAT2 on pharmacokinetic profiles of SASP and its two metabolites, sulfapyridine (SP) and N ...
Jing-Jing, Ma +5 more
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