Results 261 to 270 of about 22,235 (292)
Senescence and Cancer: Role of Nitric Oxide (NO) in SASP [PDF]
Cancers, 2020 Cellular senescence is a cell state involved in both physiological and pathological processes such as age-related diseases and cancer. While the mechanism of senescence is now well known, its role in tumorigenesis still remains very controversial. The positive and negative effects of senescence on tumorigenesis depend largely on the diversity of the ...
Stephanie Plenchette +2 more
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Calcified Tissue International, 2023 AbstractSenescence is a complex cell state characterized by stable cell cycle arrest and a unique secretory pattern known as the senescence-associated secretory phenotype (SASP). The SASP factors, which are heterogeneous and tissue specific, normally include chemokines, cytokines, growth factors, adhesion molecules, and lipid components that can lead ...
Mei Wan, Wan Mei
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SASP reflects senescence [PDF]
EMBO Reports, 2009 Senescence is a permanent state of cell cycle arrest that—unlike quiescence—is unresponsive to growth factors. Originally described in terms of the replicative exhaustion of cultured fibroblasts (Hayflick & Moorhead, 1961), it has since been shown that senescence can occur prematurely upon oncogene induction and other cellular stresses.
Masashi Narita
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International Journal of Molecular Sciences, 2022 Chemotherapy remains the most common cancer treatment. Although chemotherapeutic drugs induce tumor cell senescence, they are often associated with post-therapy tumor recurrence by inducing the senescence-associated secretory phenotype (SASP). Therefore,
Na Zhang, Baiqu Huang, Jun Lu
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The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related Diseases [PDF]
Biology, 2020 Cellular senescence represents a robust tumor-protecting mechanism that halts the proliferation of stressed or premalignant cells. However, this state of stable proliferative arrest is accompanied by the Senescence-Associated Secretory Phenotype (SASP),
Fabrizio Antonangeli +2 more
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SASP: Tumor Suppressor or Promoter? Yes! [PDF]
Trends in Cancer, 2016 Cellular senescence is a permanent growth arrest in cells with damage or stress that could lead to transformation. Some tumor cells also undergo senescence in response to chemotherapy. Senescent cells secrete cytokines and other factors of the senescence-associated secretory phenotype (SASP) that contribute to tumor suppression by enforcing arrest and ...
James G Jackson
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Astrocyte senescence and SASP in neurodegeneration: tau joins the loop
Cell Cycle, 2021Tau accumulation is a core component of Alzheimer's disease and other neurodegenerative tauopathies. While tau's impact on neurons is a major area of research, the effect of extracellular tau on astrocytes is largely unknown. This article summarizes our recent studies showing that astrocyte senescence plays a critical role in neurodegenerative diseases
Jessica Beck +2 more
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