Results 271 to 280 of about 22,235 (292)
Targeting the SASP to combat ageing: Mitochondria as possible intracellular allies? [PDF]
BioEssays, 2017 \ua9 2017 WILEY Periodicals, Inc. Anti-senescence therapies, such as drugs that specifically kill senescent cells, to stave off ageing are currently under investigation.
Jodie Birch, João F Passos
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SASP gene delivery: A novel antibacterial approach
Drug News & Perspectives, 2009Antibiotic resistance is a global problem, and with bacteria having developed resistance to all approved antibacterial agents there is a growing need for innovative solutions. Phico Therapeutics has developed a new class of antibacterial agent, a platform technology called SASPject.
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Signatures analysis systems prototype (SASP)
2009 IEEE Conference on Technologies for Homeland Security, 2009Sim-G Technologies, LLC (Sim-G), has developed a prototype collaborative system to aid in countering the threat of improvised explosive devices (IED). This is accomplished through the use of knowledge discovery, collaboration, data mining, signature visualization and GIS tools.
Dennis G. Perry +2 more
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Unmasking senescence: context-dependent effects of SASP in cancer
Nature Reviews Cancer, 2019Cellular senescence plays a critical role in tumorigenesis. Once thought of as a tissue culture artefact by some researchers, senescence is now a major field of study. Although there are common molecular mechanisms that enforce the growth arrest that characterizes the phenotype, the impact of senescence is varied and can, in some instances, have ...
Douglas V. Faget +2 more
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Effects of NAT2 polymorphism on SASP pharmacokinetics in Chinese population
Clinica Chimica Acta, 2009Sulfasalazine (SASP) pharmacologic actions are widely applied in clinical therapy. The role of N-Acetyltransferase 2 (NAT2) in the pharmacokinetics of SASP and its metabolites has not been clarified. We investigated the effects of genetic polymorphism of NAT2 on pharmacokinetic profiles of SASP and its two metabolites, sulfapyridine (SP) and N ...
Jing-Jing, Ma +5 more
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Evaluation of the mutagenicity of the anti-inflammatory drug salicylazosulfapyridine (SASP)
Mutagenesis, 1990Salicylazosulfapyridine, commonly known as sulfasalazine or SASP, is an anti-inflammatory drug that is widely used in the treatment of diseases such as ulcerative colitis and Crohn's disease. Increases in sister chromatid exchanges (SCE) and micronuclei (MN) frequencies have been reported in lymphocytes of patients maintained on SASP therapy for up to ...
J B, Bishop +3 more
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Detection of the Senescence-Associated Secretory Phenotype (SASP)
2012Cellular senescence suppresses cancer by eliminating potentially oncogenic cells, participates in tissue repair, contributes to cancer therapy, and promotes organismal aging. Numerous activities of senescent cells depend on the aptitude of these cells to secrete myriads of bioactive molecules, a behavior termed the senescence-associated secretory ...
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Symbol manipulation in FORTRAN
Communications of the ACM, 1964A set of subroutines for use in FORTRAN are described whose purpose is to synthesize output strings from (i) input strings which have been analysed by the SHADOW general syntactic analysis subroutine reported earlier, and/or (ii) packed BCD strings formed in any way.
M. J. Bailey +2 more
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[The role of SASP in tumor microenvironment.]
Clinical calcium, 2017Cellular senescence is a state of irreversible cell proliferation arrest provoked by a persistent DNA damage induced by a variety of potentially oncogenic signals, and it functions as a primary tumor-suppression mechanism. Recent studies, however, revealed that senescent cells have the potential to secrete numerous inflammatory cytokines, chemokines ...
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