Results 211 to 220 of about 26,150 (274)

The Vicious Cycle of Sleep Disruption and Inflammaging: Mechanisms, Consequences, and Therapeutic Opportunities

Aging Cell, Volume 25, Issue 11, November 2026.
Sleep disruption and circadian decline drive inflammaging and immune aging via the gut‐brain axis, NLRP3, and TLR4, forming a vicious cycle that accelerates cognitive decline and epigenetic aging. Targeting this sleep‐immune axis offers a viable strategy for promoting healthy longevity. ABSTRACT Aging is characterized by two interdependent hallmarks: a
Fu‐Ying Zhao, Jia‐Mei Wang, Shi‐Yang Lu, Liang Hao, Hai‐Yan Zhang, Hua‐Qin Wang   +5 more
wiley   +1 more source

PP2A Activation as a Senotherapeutic in Neuroblastoma. [PDF]

Cancers (Basel)
Nazam N, Shirley SN, Opara JC, Manzoor S, Shaikh MG, Brown ML, Nande P, Eakes AM, Kaimari A, Leavenworth JW, Ohlmeyer M, Beierle EA.   +11 more
europepmc   +1 more source

Pyroptotic Macrophage Extracellular Vesicles Drive miR‐103a‐3p Mediated Mitochondrial Dysfunction in Granulosa Cells in Diminished Ovarian Reserve

Aging Cell, Volume 25, Issue 11, November 2026.
Pyroptotic macrophages release extracellular vesicles enriched in miR‐103a‐3p. These EVs are taken up by granulosa cells, where miR‐103a‐3p targets MFN2 and BCL2L13, disrupting mitochondrial homeostasis and increasing oxidative stress and apoptosis. This EV‐mediated signaling axis contributes to diminished ovarian reserve and represents a potential ...
Wenhan Ju, Xin Xin, Yanli Xiao, Liwen Song, Jinfu Zhang, Shan Xiang   +5 more
wiley   +1 more source

Senescent immune cells, inflammaging, and bone loss: therapeutic potential and translational challenges of senolytics in osteoporosis. [PDF]

Front Endocrinol (Lausanne)
Zhu M, Zhang J, Fang H, Cai K, Wu Q, Gao C, Wang Y, Chen J.   +7 more
europepmc   +1 more source

Renin‐Angiotensin Signaling and Vascular Function: Insights into Health and Disease

Acta Physiologica, Volume 242, Issue 11, November 2026.
ABSTRACT The renin‐angiotensin system (RAS) is an essential regulator of vascular structure and function, and dysregulation of angiotensin II (Ang II) signaling plays a critical role in the development of hypertension and associated vascular complications.
Giovanni Bertoldi, Swapnil K. Sonkusare
wiley   +1 more source

Immunosenescence as a modifiable driver of neurodegenerative diseases: Pathways and multidimensional emerging strategies for Alzheimer's and Parkinson's diseases. [PDF]

Neurotherapeutics
Zhao J, Qu L, Guan H, Che H, Shi F, Yang Y.   +5 more
europepmc   +1 more source

Extracellular Vesicles in Dermatology: Where Are We and What Lies Ahead?

Experimental Dermatology, Volume 35, Issue 11, November 2026.
ABSTRACT Extracellular vesicles (EVs) have emerged as key players in skin biology, mediating intercellular communication across diverse physiological and pathological contexts. In this review, we critically assess the current understanding of EVs in dermatology, highlighting their roles in skin homeostasis, ageing, inflammation, wound healing and ...
Ines Martic, Alessandro Paolini, Stefania Paola Bruno, Andrea Gallego, Dorottya Ádám, Sedat Odabas, Şebnem Erçelen Ceylan, Emanuela Camera, Paloma Pérez, Attila Oláh, Andrea Masotti, Mirjana Nacka‐Aleksić, Danuta Gutowska‐Owsiak, Nsrein Ali, Maria Cavinato   +14 more
wiley   +1 more source

Advancing Our Understanding of Molecular Mechanisms in Radiation-Induced Normal Tissue Toxicity. [PDF]

Genes (Basel)
Pathak R.
europepmc   +1 more source

Inhibition of 3‐Phosphoinositide‐Dependent Kinase 1 Improves Age‐Associated Epidermal Dysfunction

Experimental Dermatology, Volume 35, Issue 11, November 2026.
ABSTRACT Epidermal aging is characterized by impaired homeostasis, including reduced cell proliferation, aberrant differentiation, deterioration of the dermal–epidermal junction (DEJ), and compromised barrier function. Accumulating evidence suggests that these alterations arise not solely from intrinsic stem cell loss but from disruption of regulatory ...
Si‐Young Cho, Hyung‐Su Kim, Seung‐Hun Kim, Kyung‐Mi Joo, Sung Yeon Cho, Sang Wook Son, Heung‐Soo Baek, Hyoung‐June Kim, Jaeyoung Ko, A Young Kim   +9 more
wiley   +1 more source