Results 211 to 220 of about 22,235 (292)

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

Integrating senotherapeutics into transplantation: liver reconditioning in an aging donor pool. [PDF]

Transpl Int
Buch ML, Esser H, Perera H, Zheng R, Ferreira-Gonzalez S, Forbes SJ.   +5 more
europepmc   +1 more source

Engineered Nestin+ TSPC‐Derived Exosomes Promote Tendon Repair Via Metabolic Reprogramming

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
Engineered Nestin+ TSPC‐derived exosomes promote tendon repair by reprogramming tenocyte metabolism via the pantothenate‐CoA‐mitochondria axis. They enhance mitochondrial function, reduce senescence and oxidative stress, restoring tendon structure and function in injured and aged models.
Linxiang Cheng, Junyu Guo, Junshu Zhang, Qiangqiang Zheng, Zhixiong Zhang, Jingyao Chen, Jinhan Zhang, Xiao Chen, Zi Yin   +8 more
wiley   +1 more source

A spatiotemporal atlas of senescence-associated secretory phenotype in fracture healing: stage-dependent mechanisms and therapeutic windows. [PDF]

Inflamm Regen
Chen B, Li G, Fang Q, Ding P, Gao Y.
europepmc   +1 more source

The Role of N6‐Methyladenosine Modification in Health and Disease

MedComm, Volume 7, Issue 6, June 2026.
N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li, Yuanhai Sun, Wanfang Zheng, Lingqin Li, Yaqian Feng, Minyou Qi, Hanbing Li   +6 more
wiley   +1 more source

Targeting Hyperoxia-Induced Cellular Senescence in Developing Human Airway Cells: Senomorphics Versus Senolytics Versus Antioxidants. [PDF]

Aging Cell
Koloko Ngassie ML, Drake LY, Zhu Y, Ortiz Y, Pfeffer-Kleemann DA, Thompson MA, Hamrick SK, Pabelick CM, Prakash YS.   +8 more
europepmc   +1 more source

Progress in Natural Products Target Discovery Technology

MedComm, Volume 7, Issue 6, June 2026.
Here, we provide a comprehensive overview of current technologies and recent advancements in therapeutic target discovery for natural products. By systematically synthesizing the principles, methodologies, and practical applications of existing experimental and computational strategies, this work provides a more actionable reference framework for ...
Qiyuan Pan, Xiao Yuan, Jinmei Jin, Xin Luan, Cheng Luo, Hongzhuan Chen, Weidong Zhang, Hao Zhang   +7 more
wiley   +1 more source

Ensemble of Time-Evolving SASP Gene Sets Identifies IGFBP7 and CDKN1A as a Potential Marker Pair for Senescent Fibroblast Subpopulations Across Tissues. [PDF]

Int J Mol Sci
Kim H, Kummerfeld E, Niedernhofer LJ, Aliferis C, Robbins PD, Wang J.   +5 more
europepmc   +1 more source

Beyond the Known and Established Neurodegenerative Effects: Roles of APOE Across a Wide Spectrum of Pathophysiological Condition

MedComm, Volume 7, Issue 6, June 2026.
APOE is widely recognized for its role in neurodegeneration and cardiovascular disease, but its different genotypes also influence body composition, affecting obesity, bone density, and muscle mass, through their central role in lipid transport and metabolism.
Miriam Frosina, Samantha Maurotti, Alberto Castagna, Tiziana Montalcini, Arturo Pujia, Luca Tirinato   +5 more
wiley   +1 more source