Results 191 to 200 of about 26,150 (274)

SASP 2026 ABSTRACTS

Scandinavian Journal of Pain
openaire   +2 more sources

Cellular senescence in ovarian cancer: a proposed geroncogenic shift linking aging, plasticity, and therapy resistance. [PDF]

Front Pharmacol
Zhang Y, Han Y, Hou P, Zhang W, Wu M, Deng M.   +5 more
europepmc   +1 more source

Microbial and Metabolic Correlates of Endometrial Dysfunction in Polycystic Ovary Syndrome: A Translational Study

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 12, Page 2092-2102, November 2026.
ABSTRACT Objective Women with polycystic ovary syndrome (PCOS) exhibit a substantially increased risk of miscarriage, yet the underlying mechanisms remain inadequately understood. This study aimed to investigate whether specific gut microbial dysbiosis and metabolic disturbance are associated with and may potentially contribute to endometrial ...
Mengyu Jing, Xi Chen, Meiyan Jiang, Huiya Fang, Xiaoming Zhu, Xuejing Jin, Yonghui Jiao, Ningning Hou, Weiwei Gong, Aixia Liu   +9 more
wiley   +1 more source

SASP in peripartum cardiomyopathy and preeclampsia

Nature Aging
openaire   +2 more sources

Cellular Senescence Dysregulates Antiviral Interferon Responses in Idiopathic Pulmonary Fibrosis

Aging Cell, Volume 25, Issue 11, November 2026.
Senescent idiopathic pulmonary fibroblasts (IPF) lung fibroblasts are transcriptomically uncoupled from a functional response to virus relative to healthy (HLF) lung fibroblasts. HLF lung fibroblasts require viral effectors STAT1 or IRF3 to enact a viral response while IPF lung fibroblasts do not rely on these axes in response to virus.
Jun‐Wei B. Hughes, Yasmina Reisser, Franziska Hornung, Tyler A. U. Hilsabeck, Fiona Senchyna, Ana L. Coelho, Tsung‐Che Ho, Kevin Schneider, David Furman, Cory M. Hogaboam, Claude Jourdan Le Saux, Pierre‐Yves Desprez, Stefanie Deinhardt‐Emmer   +12 more
wiley   +1 more source

Alterations in the Immune‐Fibrotic Axis Are Spatially Localized in the Aging Heart

Aging Cell, Volume 25, Issue 11, November 2026.
Aging does not affect the heart uniformly: unique changes in immune cells (macrophages) and scar‐forming cells (fibroblasts) first appear in the valves and aorta and spread into the heart muscle with age. Aged fibroblasts also develop features shared with human heart fibroblasts that may contribute to declining cardiovascular health.
Aleksandra Aljakna Khan, Amalia Sintou, Yue Zhao, Antonios Somarakis, Harshpreet Chandok, Juliana Alcoforado Diniz, Ramalakshmi Ramasamy, Gretchen T. Clark, Leon Frommer, Sikander Hayat, Brian S. White, Paul Robson, Ron Korstanje, J. Matthew Mahoney, Nadia A. Rosenthal   +14 more
wiley   +1 more source

Cellular senescence: six decades of discovery and reinvention. [PDF]

EMBO J
Klaver M, Steeneken LS, Veeningen N, Altulea A, Demaria M.   +4 more
europepmc   +1 more source

STORAGE-AWARE SHUFFLE PLANNER (SASP): A STORAGE-CONSTRAINED SHUFFLE OPTIMISATION LAYER FOR DISTRIBUTED COMPUTATION ENGINES

The present disclosure relates to the field of distributed data processing, in particular to storage-aware adaptive shuffle planning (SASP) for shuffle optimisation in distributed computation engines.
Khan, Raouf, Verma, Ananya
core  

Tree Shrew as an Emerging Model for Aging Research: Characterization of Senescence and Therapeutic Interventions

Aging Cell, Volume 25, Issue 11, November 2026.
Compared with mouse cells, tree shrew fibroblasts more faithfully recapitulate the hallmarks of human cellular senescence. In vivo, aged tree shrews exhibit transcriptomic signatures of aging across multiple organs that closely mirror those observed in humans.
Qiuni Luo, Wenxian Xiao, Xin Dong, Ayesha Nisar, Yuhua Ma, Xiang Lai, Raoxian Bai, Meiting Zi, Qi Geng, Qingyu Zhang, Cheng Zhang, Qiong Wang, Naheemat Modupeola Gold, Zhen Zhou, Li Hu, Ao Zhang, Qinghua Zeng, Jing Liu, Sawar Khan, Longbao Lv, Yonghan He   +20 more
wiley   +1 more source

FGF13 Alleviates the Aging Process in Mice by Regulating Astrocyte Function in the Medial Prefrontal Cortex via Phafin2 Signaling Pathway

Aging Cell, Volume 25, Issue 11, November 2026.
FGF13 is significantly downregulated in the aging brain, particularly in cortical astrocytes within the medial prefrontal cortex. Genetic knockdown of FGF13 in astrocytes accelerates aging phenotypes and impairs neurological function in mice, while its overexpression effectively delays cognitive decline.
Rui Zheng, Zheng Tu, Yang Fang, Caixiang Zhuang, Yuchao Zhang, Yibo Ying, Zhiyi Feng, Ziyang Jin, Yanyan Zheng, Zhouguang Wang   +9 more
wiley   +1 more source